(a.) Destitute of hope; having no expectation of good; despairing.
(a.) Giving no ground of hope; promising nothing desirable; desperate; as, a hopeless cause.
(a.) Unhoped for; despaired of.
Example Sentences:
(1) Its experiments are so hopelessly flawed that the results are meaningless."
(2) They were preceded by the publication of The Success and Failure of Picasso (1965) and Art and Revolution: Ernst Neizvestny and the Role of the Artist in the USSR (1969); in one, he made a hopeless mess of Picasso’s later career, though he was not alone in this; in the other, he elevated a brave dissident artist beyond his talents.
(3) Rather than ruthlessly efficient, I have found them sweet and a bit hopeless."
(4) Alcohol and drugs are influential in providing a feeling of hopelessness by their toxic effects, by disruption of interpersonal relationships and social supports, and, possibly, by manipulating neurotransmitters responsible for mood and judgment.
(5) The authors document the first 19 months of a service dedicated to the care of hopelessly ill patients in a teaching hospital.
(6) "); hopeless self-pity ("Nobody said anything to me about Billy ... all day long") and rage ("You want to put a bench in the park in Billy's name?
(7) Winston Churchill, when he was offered the role of minister of the local government board in 1906, commented: "There is no place more laborious, more anxious, more thankless, more cloaked with petty and even squalid detail, more full of hopeless and insoluble difficulties."
(8) It’s all very well for Hopeless to make fun of me saying Brexit means Brexit,” said Hapless, haplessly.
(9) Meanwhile, the dance music that sells in any quantity is just hopeless.
(10) Both depression and hopelessness were sensitive to changes in suicide risk during the one-month follow-up.
(11) Many aspects of the theory's descriptive claims about depressive thinking have been substantiated empirically, including (a) increased negativity of cognitions about the self, (b) increased hopelessness, (c) specificity of themes of loss to depressive syndromes rather than psychopathology in general, and (d) mood-congruent recall.
(12) In addition, the paper presents the author's experience with human vitreous transplantation by the 'open sky' transcorneal technique for otherwise hopeless vitreous opacities.
(13) The relationship between depression and suicide disappears when hopelessness is taken into account.
(14) The performance of controls and DST escapers was related to depth of semantic processing, whereas performance of DST suppressors varied inversely with degree of felt hopelessness.
(15) The question of vulnerability to DSH is discussed as well as the possibility of using measures of hopelessness and intropunitive hostility to identify those at greater risk of repetition.
(16) But the Labour leader has only himself to blame because of his hopelessly woolly response to a question on this in his BBC interview on Monday.
(17) "It was a certain kind of titillation the shop offered," the critic Matthew Collings has written, "sexual but also hopeless, destructive, foolish, funny, sad."
(18) Shinji Kagawa could not make any real difference and Marouane Fellaini continues to look hopelessly out of his depth.
(19) Anhedonia, diurnal variation, hopelessness, psychomotor retardation, and delusions increased with age; depressed appearance, low self-esteem, and somatic complaints decreased with age.
(20) Four cases received no treatment but were recalled, and twelve perforations showed a size and location hopeless for repair; the teeth were therefore extracted.
Incapable
Definition:
(a.) Wanting in ability or qualification for the purpose or end in view; not large enough to contain or hold; deficient in physical strength, mental or moral power, etc.; not capable; as, incapable of holding a certain quantity of liquid; incapable of endurance, of comprehension, of perseverance, of reform, etc.
(a.) Not capable of being brought to do or perform, because morally strong or well disposed; -- used with reference to some evil; as, incapable of wrong, dishonesty, or falsehood.
(a.) Not in a state to receive; not receptive; not susceptible; not able to admit; as, incapable of pain, or pleasure; incapable of stain or injury.
(a.) Unqualified or disqualified, in a legal sense; as, a man under thirty-five years of age is incapable of holding the office of president of the United States; a person convicted on impeachment is thereby made incapable of holding an office of profit or honor under the government.
(a.) As a term of disgrace, sometimes annexed to a sentence when an officer has been cashiered and rendered incapable of serving his country.
(n.) One who is morally or mentally weak or inefficient; an imbecile; a simpleton.
Example Sentences:
(1) Absorption of this serum with embryo cells eliminated cytotoxicity against MCA-2 and MCA-12 cells, but was incapable of lowering the titer against MCA-3 cells below 1:40.
(2) CP analogues that lacked the NH group at N3 or were otherwise incapable of alkyl isocyanate release were inactive.
(3) An analysis of 22 non-invasive EPEC TnphoA mutants revealed that seven have insertions in the EAF plasmid and are incapable of localized adherence.
(4) Exact comparisons of recovery of ocular tone (Maddox Wing test) between the anaesthetics were not possible as both Althesin and methohexitone rendered some patients incapable of taking the tests in the early post-operative period.
(5) Similarly, the fetus is an ideal recipient of allogeneic fetal cells as it is incapable of rejecting them early in gestation.
(6) Myocardial perfusion is best evaluated at rest and during exercise, however, alternative methods have been sought to increase coronary blood flow in patients incapable of performing adequate exercise.
(7) Cocaine was considered incapable of producing dependence in 1980 but was recently proclaimed the drug of greatest national health concern.
(8) We have documented that the profoundly depressed postcardiotomy left ventricle, initially incapable of ejection, can recover during total left ventricular unloading with the abdominal left ventricular assist device support over a seven-day period.
(9) Results are presented which show that the D-xylose isomerases present in Streptomyces olivaceus and Streptomyces phaeochromogenes NRRL B-3559 are incapable of utilizing D-lyxose as a substrate.
(10) In contrast, all three molecules were incapable of inducing IFN-alpha when added into either purified monocyte or lymphocyte cultures.
(11) Extracts of liver and lung were incapable of catabolizing any of the analogues.
(12) In fact the then president, Amadou Toumani Touré, known as "ATT" more out of derision than any sense of affection, was viewed as deeply corrupt and incapable of delivering the changes that Mali – still one of the five least-developed countries in the world – needed.
(13) On Thursday, conservative analyst Ross Douthat wrote: “A party whose leading factions often seemed incapable of budging from 1980s-era dogma suddenly caved completely.” On Friday, former top Barack Obama strategist David Axelrod tweeted : “The Day After: seems as if @GOP establishment is measuring @realDonaldTrump as a moldable vessel.
(14) I seem incapable of capturing the stories of those I meet.
(15) It can bring about specialized transduction of proAB and phoE mutants of E. coli, but it is incapable of general transduction.
(16) It said Damascus had proved itself "incapable of using its weapons systems proportionately or discriminately" and had fired lethal Scud missiles against its own cities, such as Aleppo.
(17) In the 1990s he was almost incapable of not writing a masterpiece – The Human Stain, The Plot Against America, I Married a Communist.
(18) Methaemoglobin is incapable of transporting oxygen.
(19) Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland) even at doses two logs higher than that at which the wild-type strain produces the disease.
(20) Cotransformants of yeast cells by two partially homologous plasmids, one of which is incapable of autonomous replication, has been used to construct multiply marked recombinant plasmids.