(1) In a previous analysis of the Hox-1.1 promoter in transgenic mice, we identified sequences that were sufficient to establish transgene expression in a specific region of the embryo.
(2) Thus, Hox-1.6 is involved in regional specification along the rostrocaudal axis, but only in its most rostral domain of expression.
(3) The mouse Hox 2.1 gene contains a homeobox sequence and is therefore a candidate for a vertebrate gene involved in the control of embryonic patterning or positional specification.
(4) The results show that the Hox 2.1 gene produces at least two related phosphorylated proteins present in different proportions in different tissues.
(5) Two of the hox appear to be cognates of the human Hu-1 (or mouse Hox 2.1) and the mouse Hox 1-3, while another is closely related to the mouse Hox 1-4.
(6) The expression of the eleven HOX 1 genes is lineage-restricted and these genes are predominantly detected within cells of myelomonocytic origin.
(7) Our analysis of Hox 1.3 cDNA and genomic clones indicates that the gene is organized into two exons and encodes a 270-amino-acid homeo domain protein.
(8) Southern blotting shows that the DNA sequence encoding Hox-6.1 is single copy.
(9) A 2.4 kb RNA encoded by the murine Hox 1.1 (m6) homeobox gene is induced when F9 stem cells are differentiated with retinoic acid and dibutyryl cyclic AMP.
(10) This report demonstrates that the genes in the murine Hox-2 cluster display spatially and temporally dynamic patterns of expression in the transverse plane of the developing CNS.
(11) The early transcription pattern thus appears to be compatible with a regionalizing role for the Hox-3.1 gene.
(12) Here we show correct regulation by Hox-1.1 sequences in transgenic mice and identify the elements responsible for different levels of control.
(13) The resulting Hox-2.2 misexpression produces early postnatal lethality as well as craniofacial and axial skeletal perturbations that include open eyes at birth, cleft palate, micrognathia, microtia, skull bone deficiencies, and structural and positional alterations in the vertebral column.
(14) This article reviews recent studies on the expression of the homeobox gene, Hox 2.1, during mouse embryogenesis, using the technique of in situ hybridization.
(15) In situ hybridization shows that Hox 2.1 transcripts are regionally localized in the spinal cord in an apparent anterior-posterior gradient extending from the hind brain.
(16) In this review we have built a case for abnormal Hox gene expression in human congenital malformations without presenting any direct evidence of their involvement.
(17) Hox 2.3 was also super-induced by serum, in the presence of cycloheximide, in cells rested previously in serum-free media, suggesting that new protein synthesis was not required for expressive augmentation.
(18) To further understand their regulation, the genomic loci of four newt HBox genes (two from the human HBox (HOX)-2 complex and two from the HOX-3 complex) were analysed and compared with homologous loci in other vertebrates.
(19) DNase I protection of the Hox-1.3 gene promoter region with the Hox-1.3 protein identifies a binding site 144 bp upstream from the start of transcription.
(20) The homeodomain is identical to the genomic sequence for Hox 1H, a newly identified member of the Hox 1 locus (Acampora et al.
Pox
Definition:
(n.) Strictly, a disease by pustules or eruptions of any kind, but chiefly or wholly restricted to three or four diseases, -- the smallpox, the chicken pox, and the vaccine and the venereal diseases.
(v. t.) To infect with the pox, or syphilis.
Example Sentences:
(1) Electron microscopical examination showed the presence of typical pox virions in affected epidermal cells.
(2) The NIa-like protein of plum pox virus is a protease with high sequence specificity that is autocatalytically released from the viral polyprotein.
(3) Significant increased risks were associated with a history of herpes zoster infection (odds ratio (OR): 2.3, 95% confidence interval (CI): 1.1-4.9), chicken-pox (OR: 2.1, 95% CI: 1.2-4.1) and mumps (OR: 2.0, 95% CI: 1.1-3.8).
(4) Pox virus isolated from psittacine birds was used as a vaccine in trials with love birds (Agapornis roseicollis).
(5) Ecthyma contagiosum, or orf, is an uncommon dermatosis resulting from cutaneous infection with sheep pox virus.
(6) As suggested from the high level of sequence similarity of these viral proteins with the recently described superfamilies of helicase-like proteins (3-5), the NTBM-containing cylindrical inclusion (CI) protein from plum pox virus (PPV), which belongs to the potyvirus group of positive strand RNA viruses, is shown to be able to unwind RNA duplexes.
(7) Pth and Pox induced pulmonary edema by increasing endothelium permeability without changing the hemodynamic parameters at any level of the vascular bed.
(8) We have measured glomerular filtration rate (GFR), extracellular fluid volume (ECF), oxalate distribution volume (OxDV), plasma oxalate concentration (POx.
(9) A total of 45 of the 60 birds in the aviary developed pox lesions around the beaks and eyes.
(10) The immune response of chicks to oral vaccination with HP1-strain of fowl pox virus was studied using intracellular virus alone or a combination of intra and extracellular viruses.
(11) Rhesus monkeys immunized with the soluble fraction elicited virus-neutralizing (1:1,200), complement-fixing (1:16), and hemagglutinating-inhibiting (1:80 to 1:160) antibody titers and were completely protected against monkey pox virus-induced disease.
(12) On the other hand, the binding of GuoPP[CH2]Pox to EF-2 inhibited all of these reactions strongly.
(13) There was no significant difference between immediate prehaemodialysis POx and the POx in the CAPD patients.
(14) A trypsinized preparation of Mycobacterium phlei, non specific stimulator of immunity (NSI), and Sheep Pox Virus (SPV) were inoculated in different groups of sheep to activate B-lymphocytes and induce SPV neutralizing substance(s).
(15) An infection of cattle by transmission of vaccinia virus from milkers vaccinated against small pox is reported.
(16) They refer to an outbreak of sheep-pox at Rackwitz, a place near his practice at Wollstein (Fig.
(17) The compounds also protected mice against lethal mengovirus infection and against the development of experimental pox lesions on the tail.
(18) For a rapid proving of the pig pox virus in the skin of naturally infected pigs, the simple electron microscopic method of negative staining was used.
(19) The POX1 gene encodes a 84-kDa POX protein composed of 748 amino acids.
(20) Several avian viruses (infectious bursal disease virus, Newcastle disease virus, Canary pox virus, and reovirus) formed plaques under agar.