(superl.) Very large; enormous; immense; excessive; -- used esp. of material bulk, but often of qualities, extent, etc.; as, a huge ox; a huge space; a huge difference.
Example Sentences:
(1) Handing Greater Manchester’s £6bn health and social care budget over to the city’s combined authority is the most exciting experiment in local government and the health service in decades – but the risks are huge.
(2) The Pan American Health Organization, the Americas arm of the World Health Organization, estimated the deaths from Tuesday's magnitude 7 quake at between 50,000 and 100,000, but said that was a "huge guess".
(3) Even if it were not the case that police use a variety of tricks to keep recorded crime figures low, this data would still represent an almost meaningless measure of the extent of crime in society, for the simple reason that a huge proportion of crimes (of almost all sorts) have always gone unreported.
(4) To many he was a rockstar, to me he was simply 'Dad', and I loved him hugely.
(5) The matter is now in the hands of the Guernsey police and the law officers.” One resident who is a constant target of the paper and has complained to police, Rosie Guille, said the allegations had a “huge impact on morale” on the island.
(6) "We have peace in Sierra Leone now, and Tony Blair made a huge contribution to that," said Warrant Officer Abu Bakerr Kamara.
(7) The size of Florida makes the kind of face-to-face politics of the earlier contests impossible, requiring instead huge ad spending.
(8) To augment the in vitro expansion of LAK cells, we added highly purified human recombinant interleukin-2, phytohemagglutinin and accessory cells (Uc cells) to the LAK culture system, with which huge number of LAK cells (LAK-L) were generated from originally small number of peripheral blood lymphocytes of cancer patients.
(9) The difference in Brazil will be the huge distances involved, with the crazy decision not to host the group stages in geographical clusters leading to logistical and planning nightmares.
(10) We are in the middle of the third year of huge cuts in acute hospitals' budgets," said Porter.
(11) While there has been almost no political reform during their terms of office, there have been several ambitious steps forward in terms of environmental policy: anti-desertification campaigns; tree planting; an environmental transparency law; adoption of carbon targets; eco-services compensation; eco accounting; caps on water; lower economic growth targets; the 12th Five-Year Plan; debate and increased monitoring of PM2.5 [fine particulate matter] and huge investments in eco-cities, "clean car" manufacturing, public transport, energy-saving devices and renewable technology.
(12) But it is a huge logistical problem – unique in the world.
(13) It may not point to independence – nor, given that large swaths of Wales remain firmly dominated by Labour, mean any huge advance for Plaid Cymru.
(14) Half a million homes were sold in Scotland, we lost a huge, huge chunk of stock, and as house prices began to escalate so any asset to the community has gone.
(15) There must also be strict rules in place to reduce the risks they take with shareholders' funds.Yet the huge cost of increasing capital and liquidity is forgotten when the Treasury urges them to increase lending to small and medium businesses.
(16) Toxicity has been reported in the fetus of a woman ingesting a huge overdose of digitoxin; the same result would be anticipated with digoxin poisoning.
(17) All became highly managed, "domesticated" landscapes that demanded a huge input of labour to build and maintain.
(18) Fine, but the most important new political fact is the unprecedented wave of support that has latched on to Corbyn: the hundreds of thousands who joined Labour, the thumping majority that handed him the leadership, the huge sections of the country that have tuned out of Westminster droid-talk.
(19) Calum MacLean, Grangemouth Petrochemicals chairman, says, “This is a hugely sad day for everyone at Grangemouth.
(20) I’m so happy to be joining Arsenal, a club which has a great manager, a fantastic squad of players, huge support around the world and a great stadium in London,” said Sánchez.
Hugy
Definition:
(a.) Vast.
Example Sentences:
(1) The results obtained to date are not sufficient to allow the mechanism of action of HUGI to be defined.
(2) Refresh the page and there's a non-technicolour snap of 1954 hat-trick hero Josef Hugi down there now.
(3) Negative results were obtained in the other tests, but these results serve to demonstrate that HUGI is an inhibitor well-differentiated from other glycoproteins or peptides with gastric antisecretory activity, such as urogastrone and GIP.
(4) HuGi were incubated with H3 32PO4, stimulated with PMA or cytokines, and EGF-R were immunoprecipitated; IL-1 and TNF, like PMA, caused a 2- to 5-fold increase in receptor phosphorylation.
(5) The gastric antisecretory activity of an inhibitor newly isolated from human urine (Human Urinary Gastric Inhibitor or HUGI) has been studied.
(6) Josef Hugi, the only Swiss player other than Xherdan Shaqiri to score a hat-trick at the World Cup finals.
(7) Competition experiments at 4 degrees C showed that the cytokines did not interact directly with EGF-R; Scatchard analysis of binding of [125I]EGF to HuGi after treatment with IL-1 and TNF revealed an increase in EGF-R Kd from 0.75 nM to 2.9 nM with no change in receptor number.
(8) HUGI was given intravenously and its activity determined in the following test systems: gastric secretion in the rat with pyloric ligation; gastric secretion in the dog with a Heidenhain pouch stimulated with pentagastrin, histamine and a protein meal; acid secretion by the isolated gastric mucosa of the rat; gastrointestinal motility; bile flow and gall-bladder tone and arterial and venous blood pressure and heart rate.
(9) Exposure of quiescent cultures of human gingival fibroblasts (HuGi) and porcine synovicocytes (PSF) to human recombinant interleukin 1 alpha or -beta (IL1 alpha and -beta) enhanced the rate of glycolysis as judged by increased lactate production.
(10) Half-maximal stimulation occurred at approximately 1 pM IL1; maximal stimulation (2.5-4.5-fold in HuGi, 3-7-fold in PSF) was obtained with approximately 80 pM IL1.
(11) Importantly, in HuGi made deficient in protein kinase C by prolonged incubation with PMA, addition of fresh PMA no longer affected EGF binding, while the response to IL-1 and TNF was intact.
(12) The effect of the human rIL-1 alpha and rTNF-alpha on the binding of 125I-labeled epidermal growth factor ([125I]EGF) to its receptor (EGF-R) has been studied in human gingival fibroblasts (HuGi).
(13) HUGI was found to have marked activity only in the pyloric-ligated rats and in the dogs with Heidenhain pouches stimulated by a protein meal.
(14) HuGi cells were pulse-labeled with [35S]methionine following exposure to IL1.
(15) The effect of IL-1 and TNF on EGF-R was compared with that of the tumor-promotor PMA which is known to "transmodulate" EGF-R affinity by activating protein kinase C which then phosphorylates EGF-R. PMA caused a greater inhibition of EGF binding to HuGi (80 to 85% inhibition; ED50 = 500 pM), and recovery of binding was much slower.