(1) Histochemical and electron-microscopic observations on a 30-month-old child with Hurler syndrome showed marked irregularities in chondrocyte orientation within the growth plate, along with disruption of the normal columnar architecture.
(2) Hurler syndrome, a lethal inborn error of lysosomal metabolism, results from the systemic accumulation of glycosaminoglycan.
(3) 4-Trifluoromethylumbelliferyl glycosides were applied for revealing the corresponding enzyme deficiencies upon diagnosis of Gaucher and Hurler diseases as well as GM1 gangliosidosis and alpha-mannosidosis.
(4) The distribution of complex carbohydrates has been investigated at the light and electron microscope levels in sweat glands of normal subjects and patients with Hurler's or Hunter's disease.
(5) Hurler fibroblasts corrected an abnormally high 35SO4-incorporation into acid mucopolysaccharides (MPS) in cultured fibroblasts, whereas Maroteaux-Lamy fibroblasts did not.
(6) Clear cells ("Hurler" cells) were identified within the myocardium and endocardium of both infants.
(7) DI-reactive acid material covered the luminal surface of the sweat gland, coated collagen bundles in the stroma and spared the periglandular collagenous sheath in skin from Hurler and Hunter patients as in that from normal controls.
(8) These biochemical findings clearly demonstrate enzyme differences for these two clinically distinct phenotypes and provide biochemical evidence that the Hurler and Scheie syndromes result from different allelic mutations.
(9) Even more so if "rookie" Hyun-jin Ryu doesn't get his act together tonight - the first Korean pitcher to start in the playoffs looked nothing like the impressive hurler he was in the regular season, getting hit hard by the Braves in the NLDS.
(10) Two brothers with Hurler-Scheie syndrome are presented and the oral and systemic complications each patient had described.
(11) as Rivers is as good a a hurler as they come.. You know, this game could have been different.
(12) The authors have seen eight cases of communicating hydrocephalus in children with genetic metabolic disorders, namely, one mucopolysaccharidosis I (MPS I or Hurler syndrome), one MPS II (Hunter's disease), four MPS III (Sanfilippo syndrome) two of which were siblings, and two achondroplasias.
(13) The pitching performances of their no-name hurlers are a major reason why.
(14) The clinical and roentgenographic features of these cases represent an intermediate phenotype between Hurler's syndrome and Scheie's syndrome, and both parents in each family are first cousins.
(15) Excellent discrimination between normal and affected pregnancies was provided by an estimation of the dermatan sulphate:chondroitin sulphate ratio (Hurler disease) and the heparan sulphate: chondroitin sulphate ratio (Sanfilippo disease); the use of external glycosaminoglycan standards was then unnecessary.
(16) The therapeutic effectiveness of leucocyte transfusion (LT) was compared with that of plasma infusion (PI) clinically by range of motion (ROM) of joints and biochemically from the standpoint of alpha-L-iduronidase activity and urinary excretion of acid mucopolysaccharides (AMPS) in 2 patients with Hurler's and Scheie's syndromes.
(17) 4-Trifluoromethylumbelliferyl-alpha-L-iduronide proved to be also a specific substrate of alpha-L-iduronidase and enabled to detect the enzyme deficiency in patients with Hurler disease as well as a decrease of the enzymatic activity in heterozygous carriers of the disease.
(18) In the present study, the biosynthesis, processing and secretion of alpha-L-fucosidase in I-cell and pseudo-Hurler lymphoid cells was used as a model system to study the existence of such mechanisms.
(19) Thus, they represented the Hurler syndrome clinically, while they had the enzyme defect of the Maroteaux-Lamy syndrome, and they may represent a new severe form of the Maroteaux-Lamy syndrome.
(20) Though these children had the characteristic morphological features of the Hurler syndrome, enzyme assay of cultured fibroblasts showed normal levels of alpha-L-iduronidase and decreased activity of arylsulphatase B.
Pitcher
Definition:
(n.) One who pitches anything, as hay, quoits, a ball, etc.; specifically (Baseball), the player who delivers the ball to the batsman.
(n.) A sort of crowbar for digging.
(n.) A wide-mouthed, deep vessel for holding liquids, with a spout or protruding lip and a handle; a water jug or jar with a large ear or handle.
(n.) A tubular or cuplike appendage or expansion of the leaves of certain plants.
Example Sentences:
(1) They could go out and trade for a pitcher such as the New York Mets’ Bartolo Colón , an obvious choice despite his 41 years, but he would come with an $11m price tag for next season and have to pass through the waiver wires process first – considering the wily mood Billy Beane is in this year, the A’s could be the team that blocks such a move.
(2) That is the question facing Major League Baseball pitchers who are faced with the horrendous looking but protective hat that made its debut this week.
(3) Runners at the corners for Daniel Descalso who he hits a hard ground ball right to Barmes at shortstop (not second base), he steps on the bag at second to get Freese for one out, fires to first to get the second out, and that's what we call an inning ending double play...or sometimes we call it a pitchers best friend.
(4) Electromyography and high-speed film were used to examine the muscle activity in the elbows of pitchers with medial collateral ligament insufficiency compared to the activity in uninjured elbows.
(5) 2.05am BST Cardinals 0 - Red Sox 0, top of the 4th We have a pitcher's duel ladies and gentlemen!
(6) Their acquisition of starting pitcher Ubaldo Jimenez however, well, that’s a wild one.
(7) When hall-of-fame pitcher Tom Glavine signed with the Mets, he agreed to build a new baby nursery in team-mate Joe McEwing’s home for his No47.
(8) 1.51am GMT Cardinals 2 - Red Sox 1, top of 5th AlisonW (@AlisonW) #RedSox finally doing what they do best: making the pitcher make more pitches.
(9) 1.06am GMT Red Sox 0 - Cardinals 0, bottom of the 3rd And Clay faces Lance Lynn to start off the third, and the Superman-character named pitcher works a decent at-bat, working the count to 2-2 and then fouling off the next two pitches and taking ball three to a full count.
(10) Matt Cain became the latest Giants All-Star pitcher to slide , joining Barry Zito , who started the trend, and Tim Lincecum, whose 4.37 ERA was rewarded with a two-year $35m deal, a curious decision from the front office.
(11) Five of the best S. flava : bright yellow trumpet pitchers and sulphur-yellow flowers.
(12) All of the pitchers returned to professional or college league baseball without recurrence of the ulcer.
(13) All four pitchers returned to professional baseball the year following surgical excision of the bursa.
(14) I will refrain on saying my thoughts on the National League and pitchers hitting, but all I'm saying here is that maybe it would have been more fun to see a David Oritz or Victor Martinez hitting there instead.
(15) The tying run is coming to the plate and a new pitcher is coming to the mound... Jon Smalldon (@jonsmalldon) Brandon Crawford!
(16) Manager Mike Scioscia may have one-time slugger Josh Hamilton back in time for the postseason, should he heal from rib inflammation ( if they even need him ); same goes for starting pitcher Matt Shoemaker, who has carried the team down the stretch and is recovering from a mild left rib-cage strain , not to mention his rookie hazing role as a Saudi oil tycoon.
(17) 1.05am BST Jake Peavy Dave Leese (@dl_1009) @Busfield @LengelDavid I especially like watching a pitcher who's been declared legally blind, have a go at hitting a 90mph fastball October 26, 2013 Yes, the Sox starter is legally blind without corrective lenses.
(18) These pitchers have had symptoms for some time with progressive loss of full extension of the elbow and increasing pain.
(19) Sox on the Beach (@SoxontheBeach) Also, why are the A's fans behind home plate waving towels when THEIR pitcher is in the mound?
(20) Even more so if "rookie" Hyun-jin Ryu doesn't get his act together tonight - the first Korean pitcher to start in the playoffs looked nothing like the impressive hurler he was in the regular season, getting hit hard by the Braves in the NLDS.