(1) Histochemical and electron-microscopic observations on a 30-month-old child with Hurler syndrome showed marked irregularities in chondrocyte orientation within the growth plate, along with disruption of the normal columnar architecture.
(2) Hurler syndrome, a lethal inborn error of lysosomal metabolism, results from the systemic accumulation of glycosaminoglycan.
(3) 4-Trifluoromethylumbelliferyl glycosides were applied for revealing the corresponding enzyme deficiencies upon diagnosis of Gaucher and Hurler diseases as well as GM1 gangliosidosis and alpha-mannosidosis.
(4) The distribution of complex carbohydrates has been investigated at the light and electron microscope levels in sweat glands of normal subjects and patients with Hurler's or Hunter's disease.
(5) Hurler fibroblasts corrected an abnormally high 35SO4-incorporation into acid mucopolysaccharides (MPS) in cultured fibroblasts, whereas Maroteaux-Lamy fibroblasts did not.
(6) Clear cells ("Hurler" cells) were identified within the myocardium and endocardium of both infants.
(7) DI-reactive acid material covered the luminal surface of the sweat gland, coated collagen bundles in the stroma and spared the periglandular collagenous sheath in skin from Hurler and Hunter patients as in that from normal controls.
(8) These biochemical findings clearly demonstrate enzyme differences for these two clinically distinct phenotypes and provide biochemical evidence that the Hurler and Scheie syndromes result from different allelic mutations.
(9) Even more so if "rookie" Hyun-jin Ryu doesn't get his act together tonight - the first Korean pitcher to start in the playoffs looked nothing like the impressive hurler he was in the regular season, getting hit hard by the Braves in the NLDS.
(10) Two brothers with Hurler-Scheie syndrome are presented and the oral and systemic complications each patient had described.
(11) as Rivers is as good a a hurler as they come.. You know, this game could have been different.
(12) The authors have seen eight cases of communicating hydrocephalus in children with genetic metabolic disorders, namely, one mucopolysaccharidosis I (MPS I or Hurler syndrome), one MPS II (Hunter's disease), four MPS III (Sanfilippo syndrome) two of which were siblings, and two achondroplasias.
(13) The pitching performances of their no-name hurlers are a major reason why.
(14) The clinical and roentgenographic features of these cases represent an intermediate phenotype between Hurler's syndrome and Scheie's syndrome, and both parents in each family are first cousins.
(15) Excellent discrimination between normal and affected pregnancies was provided by an estimation of the dermatan sulphate:chondroitin sulphate ratio (Hurler disease) and the heparan sulphate: chondroitin sulphate ratio (Sanfilippo disease); the use of external glycosaminoglycan standards was then unnecessary.
(16) The therapeutic effectiveness of leucocyte transfusion (LT) was compared with that of plasma infusion (PI) clinically by range of motion (ROM) of joints and biochemically from the standpoint of alpha-L-iduronidase activity and urinary excretion of acid mucopolysaccharides (AMPS) in 2 patients with Hurler's and Scheie's syndromes.
(17) 4-Trifluoromethylumbelliferyl-alpha-L-iduronide proved to be also a specific substrate of alpha-L-iduronidase and enabled to detect the enzyme deficiency in patients with Hurler disease as well as a decrease of the enzymatic activity in heterozygous carriers of the disease.
(18) In the present study, the biosynthesis, processing and secretion of alpha-L-fucosidase in I-cell and pseudo-Hurler lymphoid cells was used as a model system to study the existence of such mechanisms.
(19) Thus, they represented the Hurler syndrome clinically, while they had the enzyme defect of the Maroteaux-Lamy syndrome, and they may represent a new severe form of the Maroteaux-Lamy syndrome.
(20) Though these children had the characteristic morphological features of the Hurler syndrome, enzyme assay of cultured fibroblasts showed normal levels of alpha-L-iduronidase and decreased activity of arylsulphatase B.
Throw
Definition:
(v. t.) To give forcible utterance to; to cast; to vent.
(n.) Pain; especially, pain of travail; throe.
(n.) Time; while; space of time; moment; trice.
(v. t.) To fling, cast, or hurl with a certain whirling motion of the arm, to throw a ball; -- distinguished from to toss, or to bowl.
(v. t.) To fling or cast in any manner; to drive to a distance from the hand or from an engine; to propel; to send; as, to throw stones or dust with the hand; a cannon throws a ball; a fire engine throws a stream of water to extinguish flames.
(v. t.) To drive by violence; as, a vessel or sailors may be thrown upon a rock.
(v. t.) To cause to take a strategic position; as, he threw a detachment of his army across the river.
(v. t.) To overturn; to prostrate in wrestling; as, a man throws his antagonist.
(v. t.) To cast, as dice; to venture at dice.
(v. t.) To put on hastily; to spread carelessly.
(v. t.) To divest or strip one's self of; to put off.
(v. t.) To form or shape roughly on a throwing engine, or potter's wheel, as earthen vessels.
(v. t.) To bring forth; to produce, as young; to bear; -- said especially of rabbits.
(v. t.) To twist two or more filaments of, as silk, so as to form one thread; to twist together, as singles, in a direction contrary to the twist of the singles themselves; -- sometimes applied to the whole class of operations by which silk is prepared for the weaver.
(v. i.) To perform the act of throwing or casting; to cast; specifically, to cast dice.
(n.) The act of hurling or flinging; a driving or propelling from the hand or an engine; a cast.
(n.) A stroke; a blow.
(n.) The distance which a missile is, or may be, thrown; as, a stone's throw.
(n.) A cast of dice; the manner in which dice fall when cast; as, a good throw.
(n.) An effort; a violent sally.
(n.) The extreme movement given to a sliding or vibrating reciprocating piece by a cam, crank, eccentric, or the like; travel; stroke; as, the throw of a slide valve. Also, frequently, the length of the radius of a crank, or the eccentricity of an eccentric; as, the throw of the crank of a steam engine is equal to half the stroke of the piston.
(n.) A potter's wheel or table; a jigger. See 2d Jigger, 2 (a).
(n.) A turner's lathe; a throwe.
(n.) The amount of vertical displacement produced by a fault; -- according to the direction it is designated as an upthrow, or a downthrow.
Example Sentences:
(1) The water is embossed with small waves and it has a chill glassiness which throws light back up at the sky.
(2) The London Olympics delivered its undeniable panache by throwing a large amount of money at a small number of people who were set a simple goal.
(3) When you’ve got a man with a longer jab, you can’t throw single shots.
(4) It’s exhilarating – until you see someone throw a firework at a police horse.
(5) Marie Johansson, clinical lead at Oxford University's mindfulness centre , stressed the need for proper training of at least a year until health professionals can teach meditation, partly because on rare occasions it can throw up "extremely distressing experiences".
(6) Standing as he explains the book's take-home point, Miliband recalls the author Michael Lewis's research showing that a quarter-back is the most highly paid player, but because they throw with their right arm they can often be floored by an attacker from their blindside.
(7) Trichotomic classification of communities throws some light on the problem of causes of death of the rural and urban population.
(8) Israel has complained in recent weeks of an increase in stone throwing and molotov cocktail attacks on West Bank roads and in areas adjoining mainly Palestinian areas of Jerusalem, where an elderly motorist died after crashing his car during an alleged stoning attack.
(9) When you score a hat trick in the first 16 minutes of a World Cup Final with tens of millions of people watching across the world, essentially ending the match and clinching the tournament before most players worked up a sweat or Japan had a chance to throw in the towel, your status as a sports legend is forever secure – and any favorable comparisons thrown your way are deserved.
(10) Masood’s car struck her, throwing her into the river.
(11) Schools should adopt whole-school approaches to building emotional resilience – everyone from the dinner ladies to the headteacher needs to understand how to help young people to cope with what the modern world throws at them.
(12) Climate change is also high on protesters’ and politicians’ agendas, and the German chancellor, Angela Merkel, called for the industrial powers to throw their weight behind a longstanding pledge to seek $100bn (£65bn) to help poor countries tackle climate change, agreed in Copenhagen in 2009.
(13) In principle, the more turns and throws the stronger the knot.
(14) Ron Hogg, the PCC for Durham says that dwindling resources and a reluctance to throw people in jail over a plant (I paraphrase slightly) has led him to instruct his officers to leave pot smokers alone.
(15) But that Monday night, I went to bed and decided to throw my hat in the ring."
(16) This regulation not only guarantees the suppression of overproduction of RNA polymerase subunits but also throws light on the problem of how the syntheses of RNA polymerase and ribosome respond similarly to the shift of nutrients and temperature, but differently to the starvation for amino acids.
(17) It would also throw a light on the appalling conditions in which cheap migrant labour is employed to toil Europe's agriculturally rich southern land.
(18) Edu was tried out there in practice midweek... 2.18am GMT 6 mins Costa Rica get forward for the first time and have a throw deep in US territory.
(19) But whenever Garcia throws a left hook Matthysse really looks like he has no idea it's coming.
(20) And Myers is cautioned after a silly block 3.21am GMT 54 mins Besler with a long-throw for SKC but it's cleared.