(n.) Any one of a series of nitrogenous bases, resembling the amines and produced by the reduction of certain nitroso and diazo compounds; as, methyl hydrazine, phenyl hydrazine, etc. They are derivatives of hydrazine proper, H2N.NH2, which is a doubled amido group, recently (1887) isolated as a stable, colorless gas, with a peculiar, irritating odor. As a base it forms distinct salts. Called also diamide, amidogen, (or more properly diamidogen), etc.
Example Sentences:
(1) The first comprises N1-[4-(4-alkyloxybenzamido)benzoyl]-N2-substituted alkylidene hydrazine, the second involves 1-[4-(4-alkyloxybenzamido)benzoyl]-4-alkyl, aryl, or aralkyl-3-thiosemicarbazides, and the third includes 1-substituted-5-[4-(4-alkyloxybenzamido)phenyl]-1,3,4-triazole-2-t hione.
(2) High resolution proton NMR spectroscopic analysis of urine also revealed resonances from several metabolites of hydrazine, an N-acetylcysteine conjugate of allyl alcohol, and acetamide as a metabolite of thioacetamide after dosing with the respective compounds.
(3) When hydrazine was used as the electron donor, no substrate inhibition was observed, suggesting that the inhibition resulted from reductant limitation.
(4) The hydrazine moiety liberated from isoniazid is primarily acetylhydrazine, and studies in animals show this metabolite to be converted to a potent acylating agent that produces liver necrosis.
(5) The weekly administration of 1,2-dimethyl-hydrazine (DMH) by subcutaneous injection for a period of 16-20 weeks is a well known procedure for producing colonic tumors in mice and rats.
(6) The compounds were obtained by condensation of appropriate hydrazines with thiophene 2-carboxaldehyde (series 1), thiophene 3-carboxaldehyde (series 2), and 5-nitrothiophene-2-carboxaldehyde (series 3).
(7) After inhibition of monoamine synthesis by N'-(DL-SERYL)-N2-(2, 3, 4-trihydroxybenzyl)hydrazine, substance P significantly accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine.
(8) Embryotoxicity has been demonstrated at very high exposures but not at occupationally encountered levels for hydrazine and unsymmetrical dimethylhydrazine.
(9) The characterization of the various disaccharides by Smith periodic acid degradation and glycosidase digestions was facilitated by the preparation and thin-layer chromatographic resolution of the complete series of monosulfated derivatives of anhydromannitol and anhydrotalitol; the sulfate esters were shown to be stable to both the hydrazine and nitrous acid treatments.
(10) This inactivation was very rapid but reversible, with regeneration of enzyme activity being spontaneous and hydrazine-accelerated, suggestive of the intermediacy of a stable acyl enzyme.
(11) Urinary excretion (0-24 h) of hydrazine and its metabolite acetylhydrazine were determined employing nitrogen-phosphorus detection of the adducts utilising a novel internal standard, pentafluorophenylhydrazine, the adduct of which structurally resembles DFBA.
(12) Modification of uridines with hydrazine has no effect on interaction with the enzyme, except for one uridine near the 3'-end of tRNA(Gly).
(13) With a specific gas chromatographic assay procedure, the amount of hydrazine in the 0- to 24-hr urine was determined in patients treated with various doses of hydralazine.
(14) A chromophoric hydrazide, 4'-N,N-dimethylamino-4-azobenzene sulfonyl hydrazide (DABS-hydrazide), was prepared from 4'-N,N-dimethylamino-4-azobenzene sulfonyl chloride by reaction with hydrazine.
(15) A GC procedure for the simultaneous determination of hydrazine and benzylhydrazine in isocarboxazid raw material and tablet formulations has been developed.
(16) Hydrazine sulfate compared with placebo addition to chemotherapy resulted in significantly greater caloric intake and albumin maintenance (P less than .05).
(17) The synthesis was achieved by reacting 3-benzylthiazolidin-2-one-4-thione with its 4-hydrazone derivative to give N,N'-bis(3-benzyl-2-oxo-4-thiazolidinylidene)hydrazine, which was subjected to dibromination followed by reaction with various primary aromatic amines.
(18) This study has demonstrated that the nasal respiratory epithelia of rats and hamsters are the most sensitive tissues to the tumorigenic action of hydrazine following inhalation exposures.
(19) In the study in mice described below, which was carried out according to modern guidelines, no carcinogenic action was detected for hydrazine even after the administration of toxic doses over the entire lifespan of the animals.
(20) It is concluded that hydrazine acts to produce and altered base, possibly N(4)-aminocytosine, that produces mutations by mispairing at replication rather than by error-prone repair.
Liquid
Definition:
(a.) Flowing freely like water; fluid; not solid.
(a.) Being in such a state that the component parts move freely among themselves, but do not tend to separate from each other as the particles of gases and vapors do; neither solid nor aeriform; as, liquid mercury, in distinction from mercury solidified or in a state of vapor.
(a.) Flowing or sounding smoothly or without abrupt transitions or harsh tones.
(a.) Pronounced without any jar or harshness; smooth; as, l and r are liquid letters.
(a.) Fluid and transparent; as, the liquid air.
(a.) Clear; definite in terms or amount.
(n.) A substance whose parts change their relative position on the slightest pressure, and therefore retain no definite form; any substance in the state of liquidity; a fluid that is not aeriform.
(n.) A letter which has a smooth, flowing sound, or which flows smoothly after a mute; as, l and r, in bla, bra. M and n also are called liquids.
Example Sentences:
(1) All of the strains examined were motile and hemolytic and produced lipase and liquid gelatin.
(2) Previous attempts to purify this enzyme from the liquid endosperm of kernels of Zea mays (sweet corn) were not entirely successful owing to the lability of partially purified preparations during column chromatography.
(3) We have investigated a physiological role of endogenous insulin on exocrine pancreatic secretion stimulated by a liquid meal as well as exogenous secretin and cholecystokinin octapeptide (CCK-8) in conscious rats.
(4) Glycosyl ceramide concentration was determined by gas-liquid chromatography of the trimethylsilyl ethers of the methyl glycosides.
(5) A sensitive, selective and easy to use high-performance liquid chromatographic method for the determination of cicletanide, a new diuretic, in plasma, red blood cells, urine and saliva is described.
(6) A conventional liquid chromatograph with a low capacity column and a conductimetric detector is used to analyze aerosols of Cl-, Br-, NO-3 and SO=4 with good results.
(7) To further characterize the molecular forms of GnRH in each species, the extracts were injected into a high pressure liquid chromatograph (HPLC).
(8) Proliferation of quiescent hematopoietic stem cells, purified by cell sorting and evaluated by spleen colony assay (CFU-S), was investigated by measuring the total cell number and CFU-S content and the DNA histogram at 20 and 48 hours of liquid culture.
(9) High pressure liquid chromatography combined with radioimmunoassay showed marked heterogeneity of SPLI and SLI.
(10) After precipitation of plasma proteins by addition of methanol the samples are injected directly into the liquid chromatographic system.
(11) (2) The treated animals ingested less liquid and solid food than controls.
(12) A rapid method is described for the purification and analysis of synthetic oligonucleotides, based on reversed-phase high-performance liquid chromatography.
(13) Suspensions of isolated insect flight muscle thick filaments were embedded in layers of vitreous ice and visualized in the electron microscope under liquid nitrogen conditions.
(14) These analyses were carried out on unfractionated culture fluids and on fractions obtained by fast protein liquid chromatography separation using Superose 6 gels.
(15) The penetration coefficient, determined by the surface tension, contact angle and viscosity, is a measure of the ability of a liquid to penetrate into a capillary space, such as interproximal regions, gingival pockets and pores.
(16) Between-lot variation exceeded that of within-lot variation in 10 of the 14 liquid antacids for which this variation could be tested.
(17) The principle of the liquid and solid two-phase radioimmunoassay and its application to measuring the concentrations of triiodothyronine and thyroxine of human serum in a single sample at the same time are described in this paper.
(18) The rats were then sacrificed at either one or four hours after the injections and their brains analyzed for monoamine and metabolite content using High Performance Liquid Chromatography with Electrochemical Detection.
(19) It was like watching somebody pouring a blue liquid into a glass, it just began filling up.
(20) [8(-14)C]Inosine monophosphate formed was separated by high-voltage electrophoresis and radioactivity was measured by liquid-scintillation counting.