(1) Proteins have been partitioned in poly(ethylene glycol) (PEG)-salt systems containing hydrotropes.
(2) Multicellular spheroids from a human neuroblastoma cell line (NB1-G) were used to investigate the effect of etoposide in solution, as its commercial formulation, Vepesid, in the presence of a nonionic surfactant, Brij 30, and a hydrotropic agent, sodium salicylate.
(3) The "blow over" apparatuses Hydrotrop 200, Aquapor and VH 620 (infant) did not cause any germ propagation in the resuscitation tubes, whereas in the "blow through" apparatuses Bennett Cascade and VH 620 (adult) germ propagation is quite considerable.
(4) Additive hydrotropic effects were observed for nicotinamide and urea, which disrupt the water structure, while structure formers such as sorbitol exerted negative effects.
(5) Photon correlation spectroscopy indicated possible unfolding of BSA molecules in solutions of sodium benzoate and sodium salicylate at 25 degrees C. The effect of these hydrotropes on the heat coagulation of BSA was concentration-dependent.
(6) Different hydrotropic substances may show great differences of influence on the micellar weights and the cmc respectively.
(7) In this work, hydrotropic agents such as sodium benzoate, sodium o-hydroxybenzoate (sodium salicylate), sodium 2,5-dihydroxybenzoate (sodium gentisate), and the sodium salts of 2,4-dihydroxy- and 2,6-dihydroxybenzoic acid and of 2,4,6-trihydroxybenzoic acid have been used as alternative solubilizers of etoposide.
(8) Hydrotropes are surface active compounds with strong ionic nature with a smaller hydrophobic part as compared to surfactants.
(9) An attempt has been made to formulate a stable, aqueous injection of nifedipine (1) using the technique of hydrotropic solubilization.
(10) The effect of pH, hydrotrope concentration, polymer molecular weight and protein molecular weight on partitioning of proteins including enzymes and their separation has been investigated.
(11) The probable mechanism involves a complexation type of interaction at a low concentration of hydrotrope, aggregation of the hydrotropic molecules and inclusion of 1 in these aggregates at high concentration; and structural changes in water caused by hydrotropes.
(12) This is substantiated by measuring the concentration of hydrotropes in both the phases.
(13) Higher concentrations of the hydrotropes considerably reduced Tm and inhibited gelation of BSA, the effect of sodium salicylate being more pronounced, as was the lower aggregation rate of BSA.
(14) Preliminary experiments have shown that hydrotropes at low concentrations do not affect enzyme activity and do not have any bactericidal activity.
(15) Relatively low concentrations stabilized the protein structure as indicated by the increase in the transition temperature(Tm) and induced gelation at temperatures and BSA concentrations lower than those required in the absence of hydrotropes.
(16) The effects of hydrotropes may be explained on the basis of interaction of PEG and the hydrotropes.
(17) The effects of hydrotropic substances on the phase solubility relationship of MeT showed that inclusion complex formation with 2-HP-beta-CD depends on the degree of ordering of the solvent and is apparently subject to entropy effects.
(18) Nifedipine (1), a drug practically insoluble in water, has been solubilized employing sodium benzoate (2) and sodium salicylate (3) as hydrotropes.
(19) On the other hand, the hydrotropic salts, sodium benzoate, sodium salicylate, and sodium gentisate, are shown to be the best water solubilizers in 1-butanol.
(20) The behaviour of these hydrotropes as protein denaturants differs from that of neutral electrolytes but is similar to that of concentrated solutions of urea.
Water
Definition:
(n.) The fluid which descends from the clouds in rain, and which forms rivers, lakes, seas, etc.
(n.) A body of water, standing or flowing; a lake, river, or other collection of water.
(n.) Any liquid secretion, humor, or the like, resembling water; esp., the urine.
(n.) A solution in water of a gaseous or readily volatile substance; as, ammonia water.
(n.) The limpidity and luster of a precious stone, especially a diamond; as, a diamond of the first water, that is, perfectly pure and transparent. Hence, of the first water, that is, of the first excellence.
(n.) A wavy, lustrous pattern or decoration such as is imparted to linen, silk, metals, etc. See Water, v. t., 3, Damask, v. t., and Damaskeen.
(v. t.) An addition to the shares representing the capital of a stock company so that the aggregate par value of the shares is increased while their value for investment is diminished, or "diluted."
(v. t.) To wet or supply with water; to moisten; to overflow with water; to irrigate; as, to water land; to water flowers.
(v. t.) To supply with water for drink; to cause or allow to drink; as, to water cattle and horses.
(v. t.) To wet and calender, as cloth, so as to impart to it a lustrous appearance in wavy lines; to diversify with wavelike lines; as, to water silk. Cf. Water, n., 6.
(n.) To add water to (anything), thereby extending the quantity or bulk while reducing the strength or quality; to extend; to dilute; to weaken.
(v. i.) To shed, secrete, or fill with, water or liquid matter; as, his eyes began to water.
(v. i.) To get or take in water; as, the ship put into port to water.
Example Sentences:
(1) These surveys show that campers exposed to mountain stream water are at risk of acquiring giardiasis.
(2) 5-Azacytidine (I) stability was increased approximately 10-fold over its stability in water or lactated Ringer injection by the addition of excess sodium bisulfite and the maintenance of pH approximately 2.5.
(3) And this is the supply of 30% of the state’s fresh water.” To conduct the survey, the state’s water agency dispatches researchers to measure the level of snow manually at 250 separate sites in the Sierra Nevada, Rizzardo said.
(4) We report a case of a sudden death in a SCUBA diver working at a water treatment facility.
(5) We assessed changes in brain water content, as reflected by changes in tissue density, during the early recirculation period following severe forebrain ischemia.
(6) The water is embossed with small waves and it has a chill glassiness which throws light back up at the sky.
(7) The reduction rates of peripheral leukocytes, lung Schiff bases and lung water content were not identical in rats depleted from leukocyte after inhalation injury.
(8) And that, as much as the “on water, operational” considerations, is why we are being kept in the dark.
(9) Excretion of inactive kallikrein again correlated with urine flow rate but the regression relationship between the two variables was different for water-load-induced and frusemide-induced diuresis.
(10) The Hamilton-Wentworth regional health department was asked by one of its municipalities to determine whether the present water supply and sewage disposal methods used in a community without piped water and regional sewage disposal posed a threat to the health of its residents.
(11) Comprehensive regulations are being developed to limit human exposure to contamination in drinking water by the United States Environmental Protection Agency (EPA) under the authority of the Safe Drinking Water Act (SDWA).
(12) Undaunted by the sickening swell of the ocean and wrapped up against the chilly wind, Straneo, of Woods Hole Oceanographic Institution, one of the world's leading oceanographic research centres, continues to take measurements from the waters as the long Arctic dusk falls.
(13) Streaming is shown to occur in water in the focused beams produced by a number of medical pulse-echo devices.
(14) The role of adrenergic agents in augmenting proximal tubular salt and water flux, was studied in a preparation of freshly isolated rabbit renal proximal tubular cells in suspension.
(15) These studies also suggest at least two mechanisms for uric acid reabsorption; one sodium dependent, the other independent of sodium and water transport.
(16) Proposals to increase the tax on high-earning "non-domiciled" residents in Britain were watered down today, after intense lobbying from the business community.
(17) The amount of water, creatinine, electrolytes, proteins, and enzymes were higher during the day (up to three fold, p always less than 0.05), while equal amounts of amino acids were excreted in the day and the night period.
(18) It is especially efficacious in evaluating patients with cystic lesions, especially those with complex cysts not clearly of water density.
(19) 'The only way that child would have drowned in the bath is if you were holding her under the water.'
(20) Changes in regional cerebral blood flow (rCBF) were measured over 254 cortical regions during caloric vestibular stimulation with warm water (44 degrees C).