(n.) A compound radical, or unsaturated group, HO, consisting of one atom of hydrogen and one of oxygen. It is a characteristic part of the hydrates, the alcohols, the oxygen acids, etc.
Example Sentences:
(1) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
(2) This stimulation is mediated by one receptor with an apparent affinity of 3.3 X 10(-6) M. The hydroxyl group in the para position on phenylethanolamine was absolutely necessary to obtain an agonist whereas the meta hydroxyl group or the presence of a catechol almost suppressed the activity.
(3) The coatings formed contain only stable chemical bonds (e.g., C-C, C-O-C), and easily-derivatized hydroxyl moieties.
(4) The efficacy of both PCBOH I and III derivatives required the presence of a hydroxyl moiety and increased directly with the degree of chlorination.
(5) tert-Butyl hydroaminoxyl is detected as a degradation product of the hydroxyl adduct from all spin traps.
(6) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(7) P-1894B dose dependently reduced the hydroxylation of peptidyl proline in the fibrotic liver.
(8) The 1-carboxyalkyl nicotinamide----dihydronicotinamide redox pair is a new type of brain-enhanced chemical delivery system for drugs containing hydroxyl groups.
(9) Both adiphenine.HCl and proadifen.HCl form more stable complexes, suggesting that hydrogen bonding to the carbonyl oxygen by the hydroxyl-group on the rim of the CD ring could be an important contributor to the complexation.
(10) Enzyme-inhibiting ability for individual alkylphenols can be estimated based on the quantitative structure-activity relationship developed by Dewhirst (1980) and is a function of the free hydroxyl group, electron-donating ring substituents, and hydrophobic aromatic ring substituents.
(11) Samples of rockwool and glass fibre were compared with chrysotile fibres for their capacity to hydroxylate 2-deoxyguanosine to 8-hydroxydeoxyguanosine, a reaction that is mediated by formation of hydroxyl radicals.
(12) aldrin epoxidation, ethylmorphine demethylation, and benzo(a)-pyrene hydroxylation were induced under these conditions.
(13) Cytochrome P-450 IVA1 (or a very closely related isoenzyme in the same gene family) was a major constitutive haemoprotein in rat kidney microsomes and actively supported the omega-hydroxylation of lauric acid.
(14) In vitro sensitizing activities were correlated to the promotion efficiency of radiolytic hydroxylation of thymine to thymine glycol and to the one-electron reduction potential of a variety of fluorinated and non-fluorinated nitroazole derivatives.
(15) Ring hydroxylated saterinone and three metabolites that were not identified made up about 1-4% each.
(16) Nafimidone and other 1-imidazoles were shown to be potent inhibitors of phenytoin p-hydroxylation in rat hepatic microsomes, being very effective even at submicromolar concentrations.
(17) Only pretreatment of rabbits with rifampicin, which induces cytochrome P-450 form 3c (P-450IIIA6), significantly increased the microsomal hydroxylation of tolbutamide.
(18) Synthesis with denatured DNA as template presumably proceeds from 3'-hydroxyl termini formed at loop-back regions since the synthesized DNA product and template are covalently linked.
(19) Here we report that phenol hydroxylation to hydroquinone is also catalyzed by human myeloperoxidase in the presence of a superoxide anion radical generating system, hypoxanthine and xanthine oxidase.
(20) Mössbauer spectroscopy has been used to study the heme iron in various states of cytochrome P450cam from the camphor-hydroxylating system of the bacterium Pseudomonas putida.
Oxygen
Definition:
(n.) A colorless, tasteless, odorless, gaseous element occurring in the free state in the atmosphere, of which it forms about 23 per cent by weight and about 21 per cent by volume, being slightly heavier than nitrogen. Symbol O. Atomic weight 15.96.
(n.) Chlorine used in bleaching.
Example Sentences:
(1) Steady-state values of cell, glucose, and cellulase concentration oxygen tension, and outlet gas oxygen partial pressure were recorded.
(2) It is concluded that amlodipine reduces myocardial ischemic injury by mechanism(s) that may involve a reduction in myocardial oxygen demand as well as by positively influencing transmembrane Ca2+ fluxes during ischemia and reperfusion.
(3) Heart rate (HR), pulmonary ventilation (V), oxygen consumption (VO2), carbon dioxide production (VCO2), and respiratory quotient (RQ) were measured.
(4) Manometric studies with resting cells obtained by growth on each of these sulfur sources yielded net oxygen uptake for all substrates except sulfite and dithionate.
(5) The data indicate that ebselen is likely to be useful in the therapy of inflammatory conditions in which reactive oxygen species, such as peroxides, play an aetiological role.
(6) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
(7) Microelectrodes were used to measure the oxygen tension (PO2) profile within individual spheroids at different stages of growth.
(8) However, time in greater than 21% oxygen was significantly longer in infants less than 1000 g (median 30 days, 8.5 days in patients greater than 1000 g, p less than 0.01).
(9) Previous studies have not evaluated the potential for oxygen toxicity at 9.5 psia.
(10) The pH of ST solutions varied with the mode of oxygenation as follows: 7.9-8.2 in Groups I and IV; 8.7-8.9 in Groups II and V; 7.1-7.4 in Groups III and VI.
(11) The aim of this study was to plot the course of the transcutaneously measured PCO2 (tcPCO2) in the fetus during oxygenation of the mother.
(12) Blood gas variables produced from a computed in vivo oxygen dissociation curve, PaeO2, P95 and C(a-x)O2, were introduced in the University Hospital of Wales in 1986.
(13) Also for bronchogenic carcinoma with that a dependence could be shown between haemoglobin concentration--and by this the oxygen supply of the tumor--and the reaction of the primary tumor after radiotherapy.
(14) The present results using approximately 12% hemoglobin concentration in 0.1 M Bistris buffer at pD 7 and 27 degrees C with and without organic phosphate show that there is no significant line broadening on oxygenation (from 0 to 50% saturation) to affect the determination of the intensities or areas of these resonances.
(15) There was good agreement between the survival of normally oxygenated cells in culture and bright cells from tumors and between hypoxic cells in culture and dim cells from tumors over a radiation dosage range of 2-5 Gray.
(16) In presence of oxygen (air) the phototactic reaction values are somewhat lower than in its absence.
(17) A fiberoptic flow-directed catheter inserted into the hepatic vein continuously measures hepatic venous oxygen hemoglobin saturation (ShvO2).
(18) Anaesthesia was achieved by a mixture of oxygen, nitrous oxide and fluothane without use of muscle relaxants.
(19) The use of 100% oxygen to calculate intrapulmonary shunting in patients on PEEP is misleading in both physiological and methodological terms.
(20) Tachycardia, pulmonary hypertension, increased venous oxygen desaturation, and increasing core temperature develop as the syndrome progresses.