(n.) A compound radical, or unsaturated group, HO, consisting of one atom of hydrogen and one of oxygen. It is a characteristic part of the hydrates, the alcohols, the oxygen acids, etc.
Example Sentences:
(1) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
(2) This stimulation is mediated by one receptor with an apparent affinity of 3.3 X 10(-6) M. The hydroxyl group in the para position on phenylethanolamine was absolutely necessary to obtain an agonist whereas the meta hydroxyl group or the presence of a catechol almost suppressed the activity.
(3) The coatings formed contain only stable chemical bonds (e.g., C-C, C-O-C), and easily-derivatized hydroxyl moieties.
(4) The efficacy of both PCBOH I and III derivatives required the presence of a hydroxyl moiety and increased directly with the degree of chlorination.
(5) tert-Butyl hydroaminoxyl is detected as a degradation product of the hydroxyl adduct from all spin traps.
(6) A method for the introduction of side chains containing isonitrile (isocyanide, functional group) on the backbone of polysaccharides and other hydroxylic polymers was developed.
(7) P-1894B dose dependently reduced the hydroxylation of peptidyl proline in the fibrotic liver.
(8) The 1-carboxyalkyl nicotinamide----dihydronicotinamide redox pair is a new type of brain-enhanced chemical delivery system for drugs containing hydroxyl groups.
(9) Both adiphenine.HCl and proadifen.HCl form more stable complexes, suggesting that hydrogen bonding to the carbonyl oxygen by the hydroxyl-group on the rim of the CD ring could be an important contributor to the complexation.
(10) Enzyme-inhibiting ability for individual alkylphenols can be estimated based on the quantitative structure-activity relationship developed by Dewhirst (1980) and is a function of the free hydroxyl group, electron-donating ring substituents, and hydrophobic aromatic ring substituents.
(11) Samples of rockwool and glass fibre were compared with chrysotile fibres for their capacity to hydroxylate 2-deoxyguanosine to 8-hydroxydeoxyguanosine, a reaction that is mediated by formation of hydroxyl radicals.
(12) aldrin epoxidation, ethylmorphine demethylation, and benzo(a)-pyrene hydroxylation were induced under these conditions.
(13) Cytochrome P-450 IVA1 (or a very closely related isoenzyme in the same gene family) was a major constitutive haemoprotein in rat kidney microsomes and actively supported the omega-hydroxylation of lauric acid.
(14) In vitro sensitizing activities were correlated to the promotion efficiency of radiolytic hydroxylation of thymine to thymine glycol and to the one-electron reduction potential of a variety of fluorinated and non-fluorinated nitroazole derivatives.
(15) Ring hydroxylated saterinone and three metabolites that were not identified made up about 1-4% each.
(16) Nafimidone and other 1-imidazoles were shown to be potent inhibitors of phenytoin p-hydroxylation in rat hepatic microsomes, being very effective even at submicromolar concentrations.
(17) Only pretreatment of rabbits with rifampicin, which induces cytochrome P-450 form 3c (P-450IIIA6), significantly increased the microsomal hydroxylation of tolbutamide.
(18) Synthesis with denatured DNA as template presumably proceeds from 3'-hydroxyl termini formed at loop-back regions since the synthesized DNA product and template are covalently linked.
(19) Here we report that phenol hydroxylation to hydroquinone is also catalyzed by human myeloperoxidase in the presence of a superoxide anion radical generating system, hypoxanthine and xanthine oxidase.
(20) Mössbauer spectroscopy has been used to study the heme iron in various states of cytochrome P450cam from the camphor-hydroxylating system of the bacterium Pseudomonas putida.
Quandary
Definition:
(n.) A state of difficulty or perplexity; doubt; uncertainty.
(v. t.) To bring into a state of uncertainty, perplexity, or difficulty.
Example Sentences:
(1) He’s a great defender when he hits you but when you have guys like Matt Giteau who is light on his feet and can change direction …” And what of England, hosts of the tournament who, beset by selection quandaries, forgot the fundamentals against France last weekend.
(2) On occasions, they result in some diagnostic and therapeutic quandaries.
(3) 12.06pm BST Our own Dan Lucas was first to answer the refereeing quandary of the day, pointing out that Fifa's Law 17 says this: A goalkeeper who is injured while kicks are being taken from the penalty mark and is unable to continue as goalkeeper may be replaced by a named substitute provided his team has not used the maximum number of substitutes permitted under the competition rules.
(4) This, if anything, demonstrates the quandary and complexity of financial regulation.
(5) These two distinct paradigms lead to divergent treatment goals, which leaves the clinician in a quandary about how best to treat an individual who experiences a drinking problem.
(6) The quandary is a familiar one to every football fan who has watched his or her team score a goal while surrounded by rival supporters.
(7) "Egypt is in a quandary – it doesn't want to punish Gaza by closing the tunnels, but it needs to secure Sinai," said one western diplomat.
(8) The quandary of how to determine the value of human life and health is an essential problem but is certainly not straight forward.
(9) Some of the theoretical quandaries associated with the concept are briefly reviewed.
(10) Specific quandaries arise with involuntary hospitalization and treatment, and with evaluating patients for the courts.
(11) Since RecA protein lacks demonstrable helicase activity, the mechanism by which it pushes strand exchange through long heterologous inserts has been a quandary.
(12) This leaves Scotland's policymakers in something of a quandary: how can you tackle a problem when you don't know what is causing it?
(13) Practical solutions to the quandaries posed by the qualitative-quantitative dichotomy are explicated, with supporting methodological examples for nursing research studies.
(14) Such thirtysomething quandaries, of course, are found in greater-than-average concentration in Hollywood, where a good deal of the writers, directors and executives fall into this group; this is one reason why so many of these films have been produced.
(15) "The whole of the radio industry is in a bit of a quandary.
(16) This fixture has, in the Wenger era, been all about Arsenal's possession of the perfect answer to every quandary.
(17) One of the biggest quandaries among those who study radicalisation is identifying the point at which individuals move from "extremism" to "violent extremism".
(18) Knitting and sewing take place at its Los Angeles HQ, and it boasts an enviable benefits package for its workers (on the flipside, CEO Dov Charney has been dogged by accusations of alleged sexual harassment, which throws up its own ethical quandaries).
(19) And therein lies a quandary: how can a casual who must only say yes ever enter into a real and honest dialogue with the permanent staff who employ them?
(20) Underlying it all, there's not only rightful compassion for victims, but also perhaps relief that we don't have to face such quandaries.