(n.) A disease in which the skin is thick, rough, and scaly; -- called also fishskin.
Example Sentences:
(1) The results obtained in congenital ichthyosiform erythroderma, lamellar ichthyosis, and Papillon-Lefèvre syndrome were judged as better than those usually reported with etretinate.
(2) In this prospective study, 51 patients suffering from psoriasis and ichthyosis were treated with acitretin for 2 years.
(3) Scaling in patients with recessive X-linked ichthyosis is caused by lack of activity of the enzyme steroid sulfatase.
(4) Skin changes varied from patchy hyperkeratosis to a severe generalized ichthyosis-like condition.
(5) (1984) as autosomal dominant lamellar ichthyosis and thus confirm the existence of this new form of ichthyosis.
(6) Two brothers are described with ichthyosis, hepatosplenomegaly and signs of cerebellar degeneration.
(7) In psoriasis and ichthyosis urea is effective in creams substitution therapy.
(8) Trichothiodystrophy (TTD) is an autosomal recessive disorder characterized by brittle hair with reduced sulfur content, ichthyosis, peculiar face, and mental and physical retardation.
(9) Sex-linked ichthyosis, a rather common genodermatosis, has recently been linked with deficiency of the enzyme steroid sulfatase.
(10) Some biopsy specimens have been diagnosed as showing lamellar ichthyosis, while others have again shown psoriasis.
(11) We study here the case of a male patient aged 22 years with antecedents of Down syndrome and X-linked ichthyosis.
(12) It is concluded that the dry skin often seen in atopic dermatitis may be a mild eczematous lesion of atopic dermatitis, or a manifestation of concomitant ichthyosis, or a complex of these two changes.
(13) Founding Member and Trustee, Ichthyosis Support Group.
(14) In the human there is an X-linked gene affecting steroid sulphatase (STS) activity which, when deficient, is associated with X-linked congenital ichthyosis.
(15) In seborrheic keratoses, allergic contact dermatitis and ichthyosis vulgaris, the cytochrome oxidase activity was greatly reduced or abolished in keratinocytes, Langerhans' cells, and melanocytes, whereas the peroxidase activity was present as in normal epidermis.
(16) A unique disorder characterized by ichthyosis and defects of the appendages and teeth is reported.
(17) Three observations were made: CRBP showed little or no variations whereas CRABP was either normal (seborrheic keratosis, lichenification, nonlesional psoriatic and nonlesional Darier disease skin) or elevated (psoriatic plaques, lamellar ichthyosis, lesional Darier disease, pityriasis rubra pilaris, keratosis pilaris); high levels of CRABP might indicate a greater sensitivity of the lesions to systemic synthetic retinoids with a carboxyl group in the C15 position, and systemic administration of etretin increased the levels of CRABP but not CRBP.
(18) Steroid-sulfatase activity was absent in the cultured fibroblasts of nine affected members of eight families with sex-linked ichthyosis.
(19) The skin of a girl born with the typical appearance of "collodion baby," evolved into an exfoliative erythroderma that clinically was lamellar ichthyosis.
(20) She had striking ichthyosis and detailed investigations into the structure of the epidermis were performed.
Scleroderma
Definition:
(n.) A disease of adults, characterized by a diffuse rigidity and hardness of the skin.
Example Sentences:
(1) Immunofluorescent staining for HLA-DR showed dermal positivity in 12 of 13 involved- and 9 of 13 uninvolved-skin biopsy specimens from scleroderma patients, compared with only 1 of 10 controls.
(2) In the German Democratic Republic, patients with scleroderma and history of long term silica exposure are recognized as patients with occupational disease even though pneumoconiosis is not clearly demonstrated on X-ray film.
(3) Type II includes the Sjögren's syndrome, rhumatoid arthritis, primary biliary cirrhosis, scleroderma and autoimmune thyroid disorders.
(4) Here we present a case of systemic scleroderma with unilateral enophthalmos.
(5) A patient with scleroderma of recent onset was found to have a carcinoma of the oesophagus.
(6) It is not influenced by previous soft tissue damage induced by linear scleroderma and may enable better monitoring of the effectiveness of proposed therapies.
(7) The pathologic findings in this new case were scleroderma-like skin atrophy, arteriosclerosis, and atrophy of the endocrine glands (including the genital organs).
(8) Two hundred and thirty-seven patients with systemic sclerosis were followed prospectively in a scleroderma clinic.
(9) She had photosensitive skin of early onset, hypertrichosis, and severe scleroderma-like lesions of the hands.
(10) This family constitutes the first record of the familial coexistence of the CRST syndrome with Sjögren's syndrome, and the second evidence of vertical inheritance of scleroderma.
(11) Scleroderma should be considered in the diagnostic evaluation of joint contractures.
(12) Methods are described that are used for the titration of antinuclear, anticentromere, and anti-Scl-70 antibodies in systemic scleroderma, systemic lupus erythematosus, and rheumatoid arthritis: indirect immunofluorescence with various antigenic substrates (sections of fresh-frozen rat liver and Hep-2 cell culture), counter-current immunoelectrophoresis, isolation of Scl-70 antigen.
(13) In vivo capillaroscopic examination was performed on patients with localized scleroderma to determine whether nailfold capillary abnormalities seen in systemic scleroderma (systemic sclerosis) were also present in the localized form.
(14) Fibromyalgia patients reported significantly higher levels of learned helplessness, assessed according to a rheumatology attitudes index (RAI), than patients with all other diseases, and scleroderma patients showed significantly lower RAI scores (P less than 0.05).
(15) Six scleroderma patients had abnormal indices, two of whom had high titre ribonucleoprotein antibody.
(16) These data may indicate that intrinsic upregulation of extracellular matrix genes in scleroderma fibroblasts utilizes a TGF beta dependent pathway.
(17) In a previous paper, we have found, at post-mortem examination of three cases of scleroderma, the oesophageal smooth muscle alterations already predicted by physiologists and reported by Treacy.
(18) Pulmonary involvement was significantly more frequent in nucleolar + homogeneous FANA positive patients; moreover, in two cases the same pattern proved to predict the development of diffuse scleroderma.
(19) Only pregnancies occurring before symptom onset in the scleroderma group were considered for analysis.
(20) The haemodynamic data recorded from one patient suggested that pericardial fibrosis in scleroderma may predispose to pericardial tamponade.