(superl.) Pertaining to, resembling, or abounding in, ice; cold; frosty.
(superl.) Characterized by coldness, as of manner, influence, etc.; chilling; frigid; cold.
Example Sentences:
(1) The dog and the pig also have an endoperoxide-sensitive constrictor system activated by the 11,9-(epoxymethano) analogue of PGH2 and, of particular note, ICI 79939 and its 11-oxo analogue.
(2) The second experiments entailed use of the nonspecific opiate antagonist, naloxone, as well as the specific delta antagonist, ICI 154,129, against seizures induced by icv-administered morphine, morphiceptin, DADL, or DSLET.
(3) Leading clinical candidates have emerged from Smith Kline and French, Lilly, Merck-Frosst, ICI-Stuart and other groups.
(4) ICI 74 205, a synthetic analogue of prostaglandin F2 alpha (PGF2a) with an alkyl side chain extended by an ethyl group, was administered intravenously in 6 patients using normal saline as the vehicle.
(5) However, the pressor response to the stressors was greater in ICI 118,551- than vehicle-treated F1, but the tachycardia was equivalent for both groups.
(6) Rapid cellular uptake and metabolism of polyglutamate forms that are approximately 100-fold more potent as inhibitors of TS can translate a modest TS inhibitor such as ICI D1694 into a very potent inhibitor of cell growth (approximately 500- and approximately 10-fold more potent than CB3717 or ICI 198583, respectively).
(7) Naloxone affected CS levels in control mice and appeared to reduce the CS response to stress: ICI 154,129 and ICI 174,864 did not produce consistent effects on plasma CS levels.
(8) Treatment of hamsters with the same protocol and doses of ICI 200,880 for 8 wk prevented the destructive lesion induced by a single intratracheal dose of HNE.
(9) Tamoxifen (ICI 46474) is the trans-isomer of 1(p-beta-dimethylaminoethoxy-phenyl)-1, 2-diphenylbut-1-ene.
(10) However, with 50 nM ICI 118551 there was a reduction in the maximum response to isoprenaline.
(11) The effect of methallibure (ICI 33828) on spermatogenesis was studied in the gerbil, hedgehog, and mouse.
(12) The two LTD4 receptor antagonists (MK-571 and ICI-204,219) significantly reduced the permeability changes induced by indomethacin, while the two LTB4 antagonists (SC-41930 and LY-255,283) were without significant effect.
(13) Using a double-blind, placebo-controlled crossover design, we tested the hypothesis that the LTD4 receptor antagonist, ICI 204,219, could inhibit LTD4-induced bronchoconstriction in normal subjects.
(14) However, a glutamate antagonist (MK801) and three serotonin antagonists (ritanserin, ketanserin and ICI 170,809) were all unable to alter the MPTP effects, at the doses used in our study.
(15) However, the ICI-ER complexes that remain are in sufficient quantity to bind to gene activation reporter constructs, and in these cells, ICI still behaves as a pure antagonist of gene transcription and does not activate reporter genes.
(16) Only ICI 111,581 (5 mg kg-1) and propranolol (1 and 10 mg kg-1) prolonged P-R interval.
(17) After 7 injections of Zoladex Depot (ICI Pharma, Heidelberg, Germany), the uterus was reduced to normal size carrying dorsally a myoma of the same size.
(18) Pulse-chase experiments indicate that the half-life of the receptor is reduced from approximately 5 hr in the presence of estradiol to less than 1 hr by ICI 164,384.
(19) Plasma concentrations of AUC for ICI 169, 369 were low.
(20) The compound ICI 164,384 [N-n-butyl-N-methyl-11-(3,17 beta-dihydroxyoestra-1,3,5(10)-trien-7 alpha-yl) undecamide] was entirely devoid of oestrogenic activity in the rat and mouse uterus but completely blocked the uterine stimulatory effects of oestradiol and of tamoxifen.
Polar
Definition:
(a.) Of or pertaining to one of the poles of the earth, or of a sphere; situated near, or proceeding from, one of the poles; as, polar regions; polar seas; polar winds.
(a.) Of or pertaining to the magnetic pole, or to the point to which the magnetic needle is directed.
(a.) Pertaining to, reckoned from, or having a common radiating point; as, polar coordinates.
(n.) The right line drawn through the two points of contact of the two tangents drawn from a given point to a given conic section. The given point is called the pole of the line. If the given point lies within the curve so that the two tangents become imaginary, there is still a real polar line which does not meet the curve, but which possesses other properties of the polar. Thus the focus and directrix are pole and polar. There are also poles and polar curves to curves of higher degree than the second, and poles and polar planes to surfaces of the second degree.
Example Sentences:
(1) Using monoclonal antibodies directed against the plasma membrane of Madin-Darby canine kidney (MDCK) cells, we demonstrated previously that a glycoprotein with an Mr = 23,000 (gp23) had a non-polarized cell surface distribution and was observed on both the apical and basolateral membranes (Ojakian, G. K., Romain, R. E., and Herz, R. E. (1987) Am.
(2) It was found that linear extrapolations of log k' versus ET(30) plots to the polarity of unmodified aqueous mobile phase gave a more reliable value of log k'w than linear regressions of log k' versus volume percent.
(3) The dependence of fluorescence polarization of stained nerve fibres on the angle between the fibre axis and electrical vector of exciting light (azimuth characteristics) has been considered.
(4) A triphasic pattern was evident for the neck moments including a small phase which represented a seating of the headform on the nodding blocks of the uppermost ATD neck segment, and two larger phases of opposite polarity which represented the motion of the head relative to the trunk during the first 350 ms after impact.
(5) The remainder of the radioactivity appeared chromatographically just prior to the bisantrene peak, indicating that compounds more polar than the parent were present as transformation products.
(6) In the triploids, the 40 female chromosomes present (mouse, n = 20) were derived from a single diploid pronucleus formed after the extrusion of a first polar body, and following the monospermic fertilization of primary oocytes.
(7) Genetic regulation of the ilvGMEDA cluster involves attenuation, internal promoters, internal Rho-dependent termination sites, a site of polarity in the ilvG pseudogene of the wild-type organism, and autoregulation by the ilvA gene product, the biosynthetic L-threonine deaminase.
(8) These transcriptional experiments provide in vitro confirmation for the latent rho-dependent termination site model of transcriptional polarity.
(9) I evaluated use of the fluorescence polarization technique to measure neocarzinostatin, a proteinaceous antitumor antibiotic, and its antibody, in serum.
(10) During photoirradiation, both in vivo and in vitro, the serum polar (ZE)-bilirubin IX alpha concentration increased remarkably, but unbound-bilirubin values were not affected at all.
(11) Actin is present in chromosomal spindle fibres, with consistent polarity.
(12) The results are summarized in Table I, indicating that the ratio of formation of the cis product (2) increases as a solvent becomes more polar.
(13) No disorganization of the muscle structure was detected by polarized light and electron microscopic inspection.
(14) Subsequently, due to the rotation of the original polar axis in one hemisphere, the third cleavage plane through one half of the egg is transverse to the third cleavage plane through the other half.
(15) These activities define both the polarity of the anterior-posterior (AP) axis and the spatial domains of expression of the zygotic gap genes, which in turn control the subsequent steps in segmentation.
(16) It is released into the urine in large quantities and thus represents a potential candidate for a protein secreted in a polarized fashion from the apical plasma membrane of epithelial cells in vivo.
(17) The anodic polarization profiles are presented, as well as scanning electron micrographs and x-ray analysis of the corroded amalgam surfaces.
(18) Descending neurons have opposite structural polarity, arising in the brain and terminating in segmental regions of the fused ventral ganglia.
(19) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(20) Halothane variably increased the current produced (and therefore the estimated oxygen tension) at all polarizing voltages in saline solution equilibrated with either N2 or air.