(1) Moreover, one possible mechanism of intracellular insulin degradation is that cell surface IDE may be internalized with the insulin receptor complex and may degrade insulin during the intracellular process.
(2) These results demonstrate that the IDE is evolutionarily conserved and that its expression is tightly regulated during differentiation of Drosophila.
(3) A ventrally localized melanization inhibiting factor (MIF) has been suggested to play an important role in the establishment of the dorsal-ventral pigment pattern in Xenopus laevis [Fukuzawa and Ide:Dev.
(4) The addition of NADPH to the membranes was shown to result in the conversion of inactive protochlorophyll (ide) absorbing at about 630 nm into a form(s) with light-absorption maxima at about 640 and 652 nm, both of which disappear when chlorophyll (ide) is formed on illumination.
(5) When IDE particles are injected intravenously, the Kupffer cells of the hepatic sinusoids accumulate particles within 10 to 20 minutes, after which the clearance and excretion of IDE takes place.
(6) On the other hand the lingual IDE withdraw from the cell cycle before the corresponding labial cells.
(7) Immunoblotting experiments demonstrate that this inhibition is mediated by the reactivity of these mAbs with a 110 kDa protein, the known M(r) of IDE.
(8) A stereospecific high-performance liquid chromatographic method for the determination of (R,S)-flecainide acetate [(R,S)-N-(2-piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzam ide acetate] in human plasma and urine is described.
(9) A rapid, sensitive high-performance liquid chromatographic method has been developed for the determination of desmosine (DES) and isodesmosine (IDE), the specific cross-linking amino acids of elastin, in the tissue hydrolysates of rats.
(10) Two minutes after injection, intra- and extracellular IDE particles were found in the red pulp of the spleen.
(11) An insulin-degrading enzyme (IDE) was purified from the cytosol of human erythrocytes via the use of ammonium sulfate precipitation and chromatography on columns composed of DEAE-Sephadex, pentylagarose, hydroxylapatite, chromatofocusing resins, and Ultrogel AcA-34.
(12) Since some of these peptides have insulin-like properties, amino acid analysis of these products may enable us to identify not only the splitting position of insulin by IDE but also the site of the hormone for receptor binding.
(13) A fully automated readout unit for the BG-8 blood-grouping machine, printing Idee identification numbers with matching ABO grouping and rhesus (D) typing results is described.
(14) In vitro incubation experiments confirmed that human PMNs ingest IDE particles.
(15) The relaxant effect of cromakalim (BRL 34915), pinacidil and RP 49356 (N-methyl-2-(3-pyridyl)-tetrahydro-thiopyran-2-carbothioamide-1-ox ide) on the sustained contractions induced by 20 mM KCl were compared with the effects of nicorandil.
(16) [4R,(2E,5E)]-3-Hydroxy-2,4,6-trimethyl-2,5,7-octatriene-4-thiol ide, C11H14O2S, Mr = 210.30, hexagonal, P6(5), a = b = 9.8514 (6), c = 19.954 (1) A, V = 1677.1 A3, Z = 6, Dx = 1.249 g cm-3, lambda(Cu K alpha) = 1.5418 A, u = 23.07 cm-1, F(000) = 672, T = 298 K, R = 0.028 for 1021 unique reflections [Fo2 greater than 2 sigma(Fo2)].
(17) Row III IDE cells are also devoid of organelles related to secretory protein synthesis, although these IDE cells accumulated large pools of intracellular glycogen.
(18) Indirect studies based upon inhibitors, degradation products, and microinjected antibodies have suggested that the IDE can initiate cellular insulin degradation in mammalian cells.
(19) To further localize the site of IDE action, the fate of insulin after receptor binding was examined.
(20) In her book "Vårdandets Ide" the Finnish nurse, Katie Eriksson puts forward the thesis, that all kind af caring activities do have a common core.
Idea
Definition:
(n.) The transcript, image, or picture of a visible object, that is formed by the mind; also, a similar image of any object whatever, whether sensible or spiritual.
(n.) A general notion, or a conception formed by generalization.
(n.) Hence: Any object apprehended, conceived, or thought of, by the mind; a notion, conception, or thought; the real object that is conceived or thought of.
(n.) A belief, option, or doctrine; a characteristic or controlling principle; as, an essential idea; the idea of development.
(n.) A plan or purpose of action; intention; design.
(n.) A rational conception; the complete conception of an object when thought of in all its essential elements or constituents; the necessary metaphysical or constituent attributes and relations, when conceived in the abstract.
(n.) A fiction object or picture created by the imagination; the same when proposed as a pattern to be copied, or a standard to be reached; one of the archetypes or patterns of created things, conceived by the Platonists to have excited objectively from eternity in the mind of the Deity.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) In this book, he dismisses Freud's idea of penis envy - "Freud got it spectacularly wrong" - and said "women don't envy the penis.
(3) A backbench policy advisory group will be established to develop ideas.
(4) The idea that 80% of an engineer's time is spent on the day job and 20% pursuing a personal project is a mathematician's solution to innovation, Brin says.
(5) More disturbing than his ideas was Malema's style and tone.
(6) These data, compared with literature findings, support the idea that intratumoral BCG instillation of bladder cancer permits a longer disease-free period than other therapeutical approaches.
(7) The starting point is the idea that the current system, because it works against biodiversity but fails to increase productivity, is broken.
(8) Unlikely, he laughs: "We were founded on the idea of distributing information as far as possible."
(9) On 17 December Clegg will set out his own script for the year ahead, testing the idea that coalition governments can function even as the two parties clearly show their separate colours.
(10) This is about the best experience for our users: the idea that the experience was lacking, the innovation was lacking and we weren't reaching that ubiquity."
(11) Bose grew up with the idea, as the child of a well-to-do Bengali family in Kolkata.
(12) The observations support the idea that the function of pericytes in the choriocapillaris, the major source of nutrition for the retinal photoreceptors, resides in their contractility, and that pericytes do not remove necrotic endothelium during capillary atrophy.
(13) He was really an English public schoolboy, but I welcome the idea of people who are in some ways not Scottish, yet are committed to Scotland.
(14) Differences in scar depression also supported the idea of more stretching in the Dexon group.
(15) These results are consistent with the idea that RPE pigment dispersion is triggered by a substance that diffuses from the retina at light onset.
(16) These conclusions are consistent with those obtained from other techniques and support the idea that the effects of dopamine agonists on the activity of dopamine neurons and globus pallidus cells can provide an indication of the relative selectivity of these drugs for pre- or postsynaptic dopamine receptors.
(17) They also dismiss those who suggest that the current record-low interest rates mean countries could safely stimulate growth by raising their borrowing levels higher: Economists simply have little idea how long it will be until rates begin to rise.
(18) These results favour the idea that the factor present in peak II fraction might behave as an ouabain-like substance.
(19) You could also chat to local estate agents to get an idea of what kind of extension, if any, would appeal to buyers in your area.
(20) When the alternatives are considered, it seems most consistent with Piaget's ideas to regard both cognitive and affective phenomena as problem-solving organizations.