(1) Moreover, one possible mechanism of intracellular insulin degradation is that cell surface IDE may be internalized with the insulin receptor complex and may degrade insulin during the intracellular process.
(2) These results demonstrate that the IDE is evolutionarily conserved and that its expression is tightly regulated during differentiation of Drosophila.
(3) A ventrally localized melanization inhibiting factor (MIF) has been suggested to play an important role in the establishment of the dorsal-ventral pigment pattern in Xenopus laevis [Fukuzawa and Ide:Dev.
(4) The addition of NADPH to the membranes was shown to result in the conversion of inactive protochlorophyll (ide) absorbing at about 630 nm into a form(s) with light-absorption maxima at about 640 and 652 nm, both of which disappear when chlorophyll (ide) is formed on illumination.
(5) When IDE particles are injected intravenously, the Kupffer cells of the hepatic sinusoids accumulate particles within 10 to 20 minutes, after which the clearance and excretion of IDE takes place.
(6) On the other hand the lingual IDE withdraw from the cell cycle before the corresponding labial cells.
(7) Immunoblotting experiments demonstrate that this inhibition is mediated by the reactivity of these mAbs with a 110 kDa protein, the known M(r) of IDE.
(8) A stereospecific high-performance liquid chromatographic method for the determination of (R,S)-flecainide acetate [(R,S)-N-(2-piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzam ide acetate] in human plasma and urine is described.
(9) A rapid, sensitive high-performance liquid chromatographic method has been developed for the determination of desmosine (DES) and isodesmosine (IDE), the specific cross-linking amino acids of elastin, in the tissue hydrolysates of rats.
(10) Two minutes after injection, intra- and extracellular IDE particles were found in the red pulp of the spleen.
(11) An insulin-degrading enzyme (IDE) was purified from the cytosol of human erythrocytes via the use of ammonium sulfate precipitation and chromatography on columns composed of DEAE-Sephadex, pentylagarose, hydroxylapatite, chromatofocusing resins, and Ultrogel AcA-34.
(12) Since some of these peptides have insulin-like properties, amino acid analysis of these products may enable us to identify not only the splitting position of insulin by IDE but also the site of the hormone for receptor binding.
(13) A fully automated readout unit for the BG-8 blood-grouping machine, printing Idee identification numbers with matching ABO grouping and rhesus (D) typing results is described.
(14) In vitro incubation experiments confirmed that human PMNs ingest IDE particles.
(15) The relaxant effect of cromakalim (BRL 34915), pinacidil and RP 49356 (N-methyl-2-(3-pyridyl)-tetrahydro-thiopyran-2-carbothioamide-1-ox ide) on the sustained contractions induced by 20 mM KCl were compared with the effects of nicorandil.
(16) [4R,(2E,5E)]-3-Hydroxy-2,4,6-trimethyl-2,5,7-octatriene-4-thiol ide, C11H14O2S, Mr = 210.30, hexagonal, P6(5), a = b = 9.8514 (6), c = 19.954 (1) A, V = 1677.1 A3, Z = 6, Dx = 1.249 g cm-3, lambda(Cu K alpha) = 1.5418 A, u = 23.07 cm-1, F(000) = 672, T = 298 K, R = 0.028 for 1021 unique reflections [Fo2 greater than 2 sigma(Fo2)].
(17) Row III IDE cells are also devoid of organelles related to secretory protein synthesis, although these IDE cells accumulated large pools of intracellular glycogen.
(18) Indirect studies based upon inhibitors, degradation products, and microinjected antibodies have suggested that the IDE can initiate cellular insulin degradation in mammalian cells.
(19) To further localize the site of IDE action, the fate of insulin after receptor binding was examined.
(20) In her book "Vårdandets Ide" the Finnish nurse, Katie Eriksson puts forward the thesis, that all kind af caring activities do have a common core.
Side
Definition:
(n.) The margin, edge, verge, or border of a surface; especially (when the thing spoken of is somewhat oblong in shape), one of the longer edges as distinguished from the shorter edges, called ends; a bounding line of a geometrical figure; as, the side of a field, of a square or triangle, of a river, of a road, etc.
(n.) Any outer portion of a thing considered apart from, and yet in relation to, the rest; as, the upper side of a sphere; also, any part or position viewed as opposite to or contrasted with another; as, this or that side.
(n.) One of the halves of the body, of an animals or man, on either side of the mesial plane; or that which pertains to such a half; as, a side of beef; a side of sole leather.
(n.) The right or left part of the wall or trunk of the body; as, a pain in the side.
(n.) A slope or declivity, as of a hill, considered as opposed to another slope over the ridge.
(n.) The position of a person or party regarded as opposed to another person or party, whether as a rival or a foe; a body of advocates or partisans; a party; hence, the interest or cause which one maintains against another; a doctrine or view opposed to another.
(n.) A line of descent traced through one parent as distinguished from that traced through another.
(n.) Fig.: Aspect or part regarded as contrasted with some other; as, the bright side of poverty.
(a.) Of or pertaining to a side, or the sides; being on the side, or toward the side; lateral.
(a.) Hence, indirect; oblique; collateral; incidental; as, a side issue; a side view or remark.
(n.) Long; large; extensive.
(v. i.) To lean on one side.
(v. i.) To embrace the opinions of one party, or engage in its interest, in opposition to another party; to take sides; as, to side with the ministerial party.
(v. t.) To be or stand at the side of; to be on the side toward.
(v. t.) To suit; to pair; to match.
(v. t.) To work (a timber or rib) to a certain thickness by trimming the sides.
(v. t.) To furnish with a siding; as, to side a house.
Example Sentences:
(1) Previous use of the drug is found in more than 50 per cent of the patients, and it was often followed by a neglected side-effect.
(2) No differences between the two substances were observed with respect to side effects and general tolerability.
(3) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(4) gamma-Aminobutyric acid (GABA) and glutamate release from the treated side was higher than the control value during the first 2-3 h, a result indicating an important role of glial cells in the inactivation of released transmitter.
(5) The obvious need for highly effective contraception in women with existing disorders of glucose metabolism has led to a search for oral contraceptive (OC) regimens for such women that are efficient but without unacceptable metabolic side effects.
(6) Side effect incidence in patients treated with the paracetamol-sobrerol combination (3.7%) was significantly lower than that observed in subjects treated with paracetamol (6.1% - P less than 0.01), salicylics (25.1% - P less than 0.001), pyrazolics (12.6% - P less than 0.001), propionics (20.3%, P less than 0.001) or other antipyretics (17.9% - P less than 0.001).
(7) These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
(8) Completeness of isolation of the coronary and systemic circulations was shown by the marked difference in appearance times between the reflex hypotensive responses from catecholamine injections into the isolated coronary circulation and the direct hypertensive response from a similar injection when the circulations were connected as well as by the marked difference between the pressure pulses recorded simultaneously on both sides of the aortic balloon separating the two circulations.4.
(9) The Tyr side chain had two conformations of comparable energy, one over the ring between the Gln and Asn side chains, and the other with the Tyr side chain away from the ring.
(10) Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency.
(11) The reason for the rise in Android's market share on both sides of the Atlantic is the increased number of devices that use the software.
(12) Only those derivatives with a free amino group and net positive charge in the side chain were effective.
(13) Thus there may be four types of LPS in PACI: one contains unsubstituted core polysaccharide and yields L2 on acid hydrolysis, another has short antigenic side-chains of the SR type and yields the LI fraction, while the two high molecular weight fractions are derived from core polysaccharides with different side-chains.
(14) For retrospective action to be taken, and an FA charge to follow, the decision of the panel must be unanimous.” The match between the sides ended in acrimony and two City red cards.
(15) We studied the effect of low-dose intrathecal morphine (0.00-0.20 mg) on pain relief and the incidence of side effects after cholecystectomy in 139 patients divided into eight groups according to intrathecal morphine dose: groups 1 (0.00 mg), 2 (0.04 mg), 3 (0.06 mg), 4 (0.08 mg), 5 (0.10 mg), 6 (0.12 mg), 7 (0.15 mg), and 8 (0.20 mg).
(16) The temperature increased from the anterior to the posterior region on both buccal and lingual sides of both arches.
(17) The product of this enzymatic hydrolysis was F420 with one less glutamic acid in the side chain.
(18) On embryonic day 3.5 (E3.5), 1 day after surgery, there is a 42% average increase in volume of the polyganglia compared with the corresponding DRG on the unoperated side.
(19) Side effects were observed in 15.9% of the patients in the urapidil group and in 11.3% of the prazosin group (NS).
(20) Significant side-effects occurred infrequently and only 2 children lost weight during the period of medication.