(1) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(2) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(3) The commercially available chromogenic p-nitroanilide substrates Pro-Phe-Arg-NH-Np (S2302 or chromozym PK), Glp-Pro-Arg-NH-Np (S2366), Ile-Glu-(piperidyl)-Gly-Arg-NH-Np (S2337), and Ile-Glu-Gly-Arg-NH-Np (S2222) were tested for their suitability as substrates in these assays.
(4) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(5) Ile-tRNA synthetase shows little inactivation in either process.
(6) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(7) The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).
(8) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(9) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(10) The alpha His58(E7) to Gly and Val62(E11) to Ala substitutions caused 80- and 3-fold increases, respectively, in k'CO for T-state alpha subunits, and the alpha Val62(E11) to Ile mutation caused a 3-fold decrease.
(11) Resonances from several amino acids including His 16, Gly 24, Ile 48, and Met 61 experience strong ring-current shifts due to their placement near the heme.
(12) The terminal sequences are: NH2-Ile-Val-Gly-Gly-Ile-Asp.....Gly-Lys-Tyr-Pro-Tyr-Gln-Val-Ser-Leu-Arg-COOH.
(13) Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.
(14) Site-directed mutation of codon 203 and transient expression of these cDNA in COS-7 cells indicated that Phe, Ile, Leu, and Val permit transmembrane expression, whereas Ser, Thr, Tyr, Asn, Gly, Ala, Asp and Lys enable phosphatidylinositol-glycan attachment.
(15) The N-terminal amino acid sequence of this sialidase, Ala-Asp-X-Ile-Phe-Val-Arg-Glu-Thr-Arg-Ile-Pro-, was determined.
(16) Supplementation of the low protein diet with a synthetic mixture of branched-chain AA (Val, Leu and Ile) normalized the plasma levels of these AA.
(17) They correspond to the sequence from Leu-149 to Ile-162.
(18) The N5 atom of flavin interacts with the amide NH of Ile 59 in A.
(19) Chymotrypsin cleavage of this peptide resulted in a single-labeled fragment with the sequence: Glu-Val-Ala-Asn-(Pyridoxal-P-Lys)-Val-Gly-Gly-Ile-Tyr.
(20) Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production.
Isle
Definition:
(n.) See Aisle.
(n.) An island.
(n.) A spot within another of a different color, as upon the wings of some insects.
(v. t.) To cause to become an island, or like an island; to surround or encompass; to island.
Example Sentences:
(1) Viruses isolated from ticks (Ixodes uriae) from a seabird colony on the Isle of May, Scotland, were shown by complement fixation tests to be related to the Uukuniemi and Kemerovo serogroups.
(2) That was incorrect: for example, the Isle of Wight has never had a female MP.
(3) The problem, said Dr Kinsey, was that Shakespeare's "sceptred isle ... set in a silver sea" is now set in a sea of rubbish.
(4) But there are two key factors which are slowing down the crucial progress of renewable energy in the Western Isles.
(5) People born in the Southern Regions and in the Isles, when compared with people ever resident in Turin, have low mortality from malignancies and accidents and in general from all causes of death but respiratory diseases.
(6) Six-revolute-joint instrumented spatial linkages (6R ISLs) have become often-used devices to measure the complete six-degree-of-freedom motion of anatomical joints.
(7) Researching his book, he travelled to Kyrgyzstan, Australia, Tasmania, America, and throughout Europe and the British Isles.
(8) A curious mixture, born in South Africa and living on the Isle of Man, he draws on the oddities of both as a source for gags.
(9) Having personally witnessed their live act (Black Flag frantically twanging Bootsy’s Rubber Band) at Dingwalls in late August, I thought I’d made a great discovery until, two breathless days later, and a mere few hours before they left these fair isles, the Peppers deposited their press kit in my lap.
(10) The owners of a wind turbine factory on the Isle of Wight won a repossession order today in their attempt to end an occupation of the plant by workers protesting at planned job losses.
(11) Vestas has confirmed the closure of two sites on the Isle of Wight and Southampton with the loss of 425 jobs.
(12) Gastrointestinal tuberculosis continues to occur sporadically in hospitals in the British Isles.
(13) Most immediately in Zurich is the likely publication of a settlement made in court in the Swiss canton of Zug, in connection with alleged bribes paid to senior Fifa officials in the late 1990s by the marketing company ISL.
(14) Nearly 11,000 islanders had objected to the scheme, which had been supported by the Western Isles council and the island's main community trust.
(15) The exhibition will include the earliest roadside pillar box erected on the mainland – in 1853, a year after the first went up in Jersey in the Channel Isles – and unique and priceless sheets of Penny Black stamps.
(16) Six systems for defining and evaluating disease activity in patients with systemic lupus erythematosus (SLE) (the Ropes system, the National Institutes of Health [NIH] system, the New York Hospital for Special Surgery system, the British Isles Lupus Assessment Group [BILAG] scale, the University of Toronto SLE Disease Activity Index [SLE-DAI], and the Systemic Lupus Activity Measure [SLAM]) were tested on 25 SLE patients who were selected to represent a range of disease activity.
(17) 'A n excessive sense of entitlement" was what the mayor of London ascribed to those looting their way across our sceptred isle – but he could have been referring to himself.
(18) The apogee, for me, is his book Terra Nullius , a 2005 Australia travelogue that indicts Britons and white Australians for terrible abuses such as the transportation of Aborigine women to the chillingly named Isle of the Dead where they were given inappropriate and often fatal syphilis treatment, and the extensive forced separation of "half-blood" children from their families to prison-like camps.
(19) Information will be available at goldenballyork.co.uk • Today sees the official re-opening of one of the British Isles's most remote convenience stores.
(20) He has a fixation with islands (Cyprus, Sicily, The Tempest 's nameless "isle").