(1) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(2) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(3) The commercially available chromogenic p-nitroanilide substrates Pro-Phe-Arg-NH-Np (S2302 or chromozym PK), Glp-Pro-Arg-NH-Np (S2366), Ile-Glu-(piperidyl)-Gly-Arg-NH-Np (S2337), and Ile-Glu-Gly-Arg-NH-Np (S2222) were tested for their suitability as substrates in these assays.
(4) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(5) Ile-tRNA synthetase shows little inactivation in either process.
(6) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(7) The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).
(8) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(9) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(10) The alpha His58(E7) to Gly and Val62(E11) to Ala substitutions caused 80- and 3-fold increases, respectively, in k'CO for T-state alpha subunits, and the alpha Val62(E11) to Ile mutation caused a 3-fold decrease.
(11) Resonances from several amino acids including His 16, Gly 24, Ile 48, and Met 61 experience strong ring-current shifts due to their placement near the heme.
(12) The terminal sequences are: NH2-Ile-Val-Gly-Gly-Ile-Asp.....Gly-Lys-Tyr-Pro-Tyr-Gln-Val-Ser-Leu-Arg-COOH.
(13) Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.
(14) Site-directed mutation of codon 203 and transient expression of these cDNA in COS-7 cells indicated that Phe, Ile, Leu, and Val permit transmembrane expression, whereas Ser, Thr, Tyr, Asn, Gly, Ala, Asp and Lys enable phosphatidylinositol-glycan attachment.
(15) The N-terminal amino acid sequence of this sialidase, Ala-Asp-X-Ile-Phe-Val-Arg-Glu-Thr-Arg-Ile-Pro-, was determined.
(16) Supplementation of the low protein diet with a synthetic mixture of branched-chain AA (Val, Leu and Ile) normalized the plasma levels of these AA.
(17) They correspond to the sequence from Leu-149 to Ile-162.
(18) The N5 atom of flavin interacts with the amide NH of Ile 59 in A.
(19) Chymotrypsin cleavage of this peptide resulted in a single-labeled fragment with the sequence: Glu-Val-Ala-Asn-(Pyridoxal-P-Lys)-Val-Gly-Gly-Ile-Tyr.
(20) Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production.
Mile
Definition:
(n.) A certain measure of distance, being equivalent in England and the United States to 320 poles or rods, or 5,280 feet.
Example Sentences:
(1) On 9 January 2002, a few hours after Blair became the first western leader to visit Afghanistan's new post-Taliban leader, Hamid Karzai, an aircraft carrying the first group of MI5 interrogators touched down at Bagram airfield, 32 miles north of Kabul.
(2) One man has died in storms sweeping across the UK that have brought 100-mile-an-hour winds and led to more than 50 flood warnings being issued with widespread disruption on the road and rail networks in much of southern England and Scotland.
(3) It is not that the concept of food miles is wrong; it is just too simplistic, say experts.
(4) Tepco has taken on a US consultant, Lake Barrett , who led the NRC's cleanup of Three Mile Island, the worst commercial nuclear power accident in the nation's history.
(5) "Runners, for instance, need a high level of running economy, which comes from skill acquisition and putting in the miles," says Scrivener, "But they could effectively ease off the long runs and reduce the overall mileage by introducing Tabata training.
(6) Liu was a driving force behind the modernisation of China's rail system, a project that included building 10,000 miles of high-speed rail track by 2020 – with a budget of £170bn, one of the most expensive engineering feats in recent history.
(7) Asked if his donation to Filner, who has a district about 2,500 miles from where Sharif lives, was because of his position on Iran and the MEK, Sharif said that it was.
(8) Similarly, while those in the City continue to adopt a Millwall FC-style attitude of "no one likes us, we don't care", there is no incentive for them to heed the advice and demands of the public, who those in the Square Mile prefer to dismiss as intemperate ignoramuses.
(9) I want to follow the west bank of the river south for some 100 miles to a bluff overlooking the river, where Sitting Bull is buried – and then, in the evening, to return to Bismarck.
(10) But after 26.2 miles of pain it may be harder to keep that smile on his face.
(11) Miles will be replaced in September by former hedge fund economist Gertjan Vlieghe .
(12) Guzmán was sent to Altiplano high-security prison, 56 miles outside Mexico City, but in July 2015, he absconded again, squeezing through a hole in his shower floor then fleeing on a modified motorbike through a mile-long tunnel fitted with lights and a ventilation system.
(13) Miles Shipside, Rightmove director, said: "The number of new sellers is slightly up on the same period last year, though perhaps as a reflection of their urgency to sell, or to compensate for the distraction of the achievements served up by Team GB, they have dropped their asking prices more aggressively than summer sellers in previous years."
(14) The closest town of any size is Burns, population 2,806, where you should stock up on petrol, food and water before heading south into the wilderness on the 66-mile Steens Mountain Backcountry Byway.
(15) The following year, I organised and took part in a cycle ride from John O'Groats to Land's End, covering 900 miles in nine days through this beautiful country.
(16) You had to let it crash over you.” Facebook Twitter Pinterest ‘Miles’s life was torture’ … Lu Spinney at home.
(17) Her unclothed remains were found six months later by mushroom pickers at Yateley Heath Woods, near Fleet, Hampshire, 25 miles away.
(18) The young screenwriters possibly needed to have chalked up a few miles before they could deliver really workable scripts."
(19) "It could be the difference between really struggling over the last three or four miles and getting over the finishing line before you dehydrate.
(20) Just one problem (apart from the old roof falling off): it's 60 miles from my desk.