(1) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(2) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(3) The commercially available chromogenic p-nitroanilide substrates Pro-Phe-Arg-NH-Np (S2302 or chromozym PK), Glp-Pro-Arg-NH-Np (S2366), Ile-Glu-(piperidyl)-Gly-Arg-NH-Np (S2337), and Ile-Glu-Gly-Arg-NH-Np (S2222) were tested for their suitability as substrates in these assays.
(4) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(5) Ile-tRNA synthetase shows little inactivation in either process.
(6) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(7) The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).
(8) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(9) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(10) The alpha His58(E7) to Gly and Val62(E11) to Ala substitutions caused 80- and 3-fold increases, respectively, in k'CO for T-state alpha subunits, and the alpha Val62(E11) to Ile mutation caused a 3-fold decrease.
(11) Resonances from several amino acids including His 16, Gly 24, Ile 48, and Met 61 experience strong ring-current shifts due to their placement near the heme.
(12) The terminal sequences are: NH2-Ile-Val-Gly-Gly-Ile-Asp.....Gly-Lys-Tyr-Pro-Tyr-Gln-Val-Ser-Leu-Arg-COOH.
(13) Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.
(14) Site-directed mutation of codon 203 and transient expression of these cDNA in COS-7 cells indicated that Phe, Ile, Leu, and Val permit transmembrane expression, whereas Ser, Thr, Tyr, Asn, Gly, Ala, Asp and Lys enable phosphatidylinositol-glycan attachment.
(15) The N-terminal amino acid sequence of this sialidase, Ala-Asp-X-Ile-Phe-Val-Arg-Glu-Thr-Arg-Ile-Pro-, was determined.
(16) Supplementation of the low protein diet with a synthetic mixture of branched-chain AA (Val, Leu and Ile) normalized the plasma levels of these AA.
(17) They correspond to the sequence from Leu-149 to Ile-162.
(18) The N5 atom of flavin interacts with the amide NH of Ile 59 in A.
(19) Chymotrypsin cleavage of this peptide resulted in a single-labeled fragment with the sequence: Glu-Val-Ala-Asn-(Pyridoxal-P-Lys)-Val-Gly-Gly-Ile-Tyr.
(20) Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production.
Pile
Definition:
(n.) A hair; hence, the fiber of wool, cotton, and the like; also, the nap when thick or heavy, as of carpeting and velvet.
(n.) A covering of hair or fur.
(n.) The head of an arrow or spear.
(n.) A large stake, or piece of timber, pointed and driven into the earth, as at the bottom of a river, or in a harbor where the ground is soft, for the support of a building, a pier, or other superstructure, or to form a cofferdam, etc.
(n.) One of the ordinaries or subordinaries having the form of a wedge, usually placed palewise, with the broadest end uppermost.
(v. t.) To drive piles into; to fill with piles; to strengthen with piles.
(n.) A mass of things heaped together; a heap; as, a pile of stones; a pile of wood.
(n.) A mass formed in layers; as, a pile of shot.
(n.) A funeral pile; a pyre.
(n.) A large building, or mass of buildings.
(n.) Same as Fagot, n., 2.
(n.) A vertical series of alternate disks of two dissimilar metals, as copper and zinc, laid up with disks of cloth or paper moistened with acid water between them, for producing a current of electricity; -- commonly called Volta's pile, voltaic pile, or galvanic pile.
(n.) The reverse of a coin. See Reverse.
(v. t.) To lay or throw into a pile or heap; to heap up; to collect into a mass; to accumulate; to amass; -- often with up; as, to pile up wood.
(v. t.) To cover with heaps; or in great abundance; to fill or overfill; to load.
Example Sentences:
(1) Electron microscopy revealed the presence of a hitherto unreported peculiar "pilovacuolar" inclusion in numerous mitochondria, composed of an electron dense pile or rod within a vacuole, while globular or crystalline inclusions were absent.
(2) Piling refugees on trains in the hopes that they go far, far away brings back memories of the darkest period of our continent,” he told Der Spiegel.
(3) After the gunfight the marines made the shocking discovery of bodies of 58 men and 14 women in a room, some piled on top of each other.
(4) Chris Williamson, of data provider Markit, said: "A batch of dismal data and a gloomier assessment of the economic outlook has cast a further dark cloud over the UK's economic health, piling pressure on the government to review its fiscal policy and growth strategy.
(5) This is a substantial country, not just a pile of bricks.
(6) Then they become increasingly unable to afford the probation fees that are piled on by private companies paid to oversee them, including fees for everything from basic supervision to drug tests.
(7) For each indicated educational--motivating unity parents have to be completely prepared for better and more complete than usual piling of facts and presenting in front of them unsolvable tasks and obligations.
(8) According to its physical and biochemical properties, poly(L-malate) may alternatively function as a molecular chaperone in nucleosome assembly in the S phase and as both an inhibitor and a stock-piling agent of DNA-polymerase-alpha-primase in the G2 phase and M phase of the plasmodial cell cycle.
(9) You’d think such a spry, successful man would busy himself with other things besides crawling into a pile of stuffed animals to scare his daughter’s date.
(10) In the spare room, there was a pile of CVs aimed at charities to secure this “free labour” imposed by the benefits system.
(11) Vote for me, and I will complete the job of rebalancing it... January 28, 2014 12.03pm GMT Britain's businesses need to stop sitting on their cash piles and crank up their investment, argues IPPR’s chief economist Tony Dolphin: “The news that manufacturing is growing is welcome.
(12) There are 80,000 bars and restaurants there and they're often piled eight stories high on top of each other.
(13) Cards pile on the runs, and here comes Hurdle to get Burnett, about three batters too late.
(14) When my floor was dirty, I rose early, and, setting all my furniture out of doors on the grass, bed and bedstead making but one budget, dashed water on the floor, and sprinkled white sand from the pond on it, and then with a broom scrubbed it clean and white... Further - and this is a stroke of his sensitive, pawky genius - he contemplates his momentarily displaced furniture and the nuance of enchanting strangeness: It was pleasant to see my whole household effects out on the grass, making a little pile like a gypsy's pack, and my three-legged table, from which I did not remove the books and pen and ink, standing amid the pines and hickories ...
(15) Rather, it's because because policymakers and administrators have come to treat higher education as a commercial marketplace, rather than a public trust – and stop-gap student loan reforms like those "unveiled" by President Obama this week fail to confront this ethical dilemma underlying the debt pile.
(16) There is a half-drunk glass of white wine abandoned on the coffee table at his Queensferry home - the Browns had friends around for dinner the previous night - and a stack of children's books and board games piled lopsidedly under a Christmas tree now shedding needles with abandon.
(17) Signs that large companies are ready to start spending some of the cash piles they have been sitting on while smaller firms are prepared to borrow to expand reflect a brighter outlook for sales.
(18) Britain's Serious Fraud Office has launched a formal criminal investigation into GlaxoSmithKline's sales practices, piling further pressure on the drugmaker which is already being investigated by Chinese authorities and elsewhere amid allegations of bribery.
(19) After more than a quarter of a century of camping out, the house, with its seven flights of stairs (a trial to Lessing in her final years), seemed almost to be supported by a precarious interior scaffolding of piles of books and shelves.
(20) The ONS said UK's debt pile had risen to £1.11tn or 70.7% of GDP.