(1) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(2) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(3) The commercially available chromogenic p-nitroanilide substrates Pro-Phe-Arg-NH-Np (S2302 or chromozym PK), Glp-Pro-Arg-NH-Np (S2366), Ile-Glu-(piperidyl)-Gly-Arg-NH-Np (S2337), and Ile-Glu-Gly-Arg-NH-Np (S2222) were tested for their suitability as substrates in these assays.
(4) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(5) Ile-tRNA synthetase shows little inactivation in either process.
(6) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(7) The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).
(8) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(9) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(10) The alpha His58(E7) to Gly and Val62(E11) to Ala substitutions caused 80- and 3-fold increases, respectively, in k'CO for T-state alpha subunits, and the alpha Val62(E11) to Ile mutation caused a 3-fold decrease.
(11) Resonances from several amino acids including His 16, Gly 24, Ile 48, and Met 61 experience strong ring-current shifts due to their placement near the heme.
(12) The terminal sequences are: NH2-Ile-Val-Gly-Gly-Ile-Asp.....Gly-Lys-Tyr-Pro-Tyr-Gln-Val-Ser-Leu-Arg-COOH.
(13) Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.
(14) Site-directed mutation of codon 203 and transient expression of these cDNA in COS-7 cells indicated that Phe, Ile, Leu, and Val permit transmembrane expression, whereas Ser, Thr, Tyr, Asn, Gly, Ala, Asp and Lys enable phosphatidylinositol-glycan attachment.
(15) The N-terminal amino acid sequence of this sialidase, Ala-Asp-X-Ile-Phe-Val-Arg-Glu-Thr-Arg-Ile-Pro-, was determined.
(16) Supplementation of the low protein diet with a synthetic mixture of branched-chain AA (Val, Leu and Ile) normalized the plasma levels of these AA.
(17) They correspond to the sequence from Leu-149 to Ile-162.
(18) The N5 atom of flavin interacts with the amide NH of Ile 59 in A.
(19) Chymotrypsin cleavage of this peptide resulted in a single-labeled fragment with the sequence: Glu-Val-Ala-Asn-(Pyridoxal-P-Lys)-Val-Gly-Gly-Ile-Tyr.
(20) Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production.
Vile
Definition:
(superl.) Low; base; worthless; mean; despicable.
(superl.) Morally base or impure; depraved by sin; hateful; in the sight of God and men; sinful; wicked; bad.
Example Sentences:
(1) Those behind it have once again taken the law into their own hands and dispensed a vile form of rough justice.
(2) The deputy prime minister branded the treatment meted out to the four-year-old by his mother, Magdelena Luczak, and stepfather, Mariusz Krezolek, as evil and vile, but suggested it was up to the whole of society to stop such tragedies.
(3) Charlie Morris described the column as "vile and disgusting", adding that she hoped the writer "gets the sack".
(4) In China, where the Communist party has always determined which news is fit to print, authorities have ordered internet portals to abandon original reporting on political or social topics because of its “ extremely vile effect ”.
(5) The massacre was not committed by "the Poles" against "the Jews", but was a vile crime committed by specific individuals.
(6) Daryush 'Roosh V' Valizadeh cancels neo-masculinist meetings over safety Read more Roosh and company encountered such uniform hostility because their views are ostentatiously vile.
(7) Much porn is samey and some is utterly vile, full of torture, faeces, urine, vomit and blood and the utter degradation of women who become nothing but a series of orifices.
(8) Labour leader Jeremy Corbyn claimed the results so far illustrated that the Conservatives’ “vile campaign” had backfired .
(9) This whole vile outpouring may just be par for the course in the wilds of social media.
(10) I did, though, have my suspicions that the perpetrator of this vile assault was Dolge Orlick, Joe's journeyman apprentice.
(11) The description “whorephobic” is usually reserved for feminists who speak or campaign against the liberalisation of the laws on sex work, who dream of a world where this huge, vile industry doesn’t exist.
(12) It is true in both cases that secrecy helps to protect some truly vile criminals, terrorists and paedophiles.
(13) It was not that he could not play good guys; rather that he excelled at locating the virtues in the apparently vile.
(14) Jowell said: "Harriet Harman would have nothing to do with the vile rubbish of an organisation like PIE," adding: "I don't want anyone to think this present frenzy about Harriet, the NCCL and the Daily Mail attack on her is in any way explained by that was then and this is now."
(15) Last year the country's most senior judge said only "extremely vile criminals" were executed in 2007 as a result of "kill fewer, kill carefully" reforms that gave the supreme court the right to overturn capital sentences handed down by lower courts.
(16) You need locking up.” Vardy posted a screenshot of the threats with the words “shocking and vile”.
(17) "That is why I believe George Osborne's calculated decision to use the shocking and vile crimes of Mick Philpott to advance a political argument is the cynical act of a desperate chancellor.
(18) Vile stuff – but the Nazi attitude to modern art may have been radically misunderstood.
(19) "They will not further any aim or objective by their vile and callous deeds.
(20) Vile returned to Philadelphia and enrolled at a community college.