(1) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(2) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(3) The commercially available chromogenic p-nitroanilide substrates Pro-Phe-Arg-NH-Np (S2302 or chromozym PK), Glp-Pro-Arg-NH-Np (S2366), Ile-Glu-(piperidyl)-Gly-Arg-NH-Np (S2337), and Ile-Glu-Gly-Arg-NH-Np (S2222) were tested for their suitability as substrates in these assays.
(4) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(5) Ile-tRNA synthetase shows little inactivation in either process.
(6) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(7) The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).
(8) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(9) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(10) The alpha His58(E7) to Gly and Val62(E11) to Ala substitutions caused 80- and 3-fold increases, respectively, in k'CO for T-state alpha subunits, and the alpha Val62(E11) to Ile mutation caused a 3-fold decrease.
(11) Resonances from several amino acids including His 16, Gly 24, Ile 48, and Met 61 experience strong ring-current shifts due to their placement near the heme.
(12) The terminal sequences are: NH2-Ile-Val-Gly-Gly-Ile-Asp.....Gly-Lys-Tyr-Pro-Tyr-Gln-Val-Ser-Leu-Arg-COOH.
(13) Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.
(14) Site-directed mutation of codon 203 and transient expression of these cDNA in COS-7 cells indicated that Phe, Ile, Leu, and Val permit transmembrane expression, whereas Ser, Thr, Tyr, Asn, Gly, Ala, Asp and Lys enable phosphatidylinositol-glycan attachment.
(15) The N-terminal amino acid sequence of this sialidase, Ala-Asp-X-Ile-Phe-Val-Arg-Glu-Thr-Arg-Ile-Pro-, was determined.
(16) Supplementation of the low protein diet with a synthetic mixture of branched-chain AA (Val, Leu and Ile) normalized the plasma levels of these AA.
(17) They correspond to the sequence from Leu-149 to Ile-162.
(18) The N5 atom of flavin interacts with the amide NH of Ile 59 in A.
(19) Chymotrypsin cleavage of this peptide resulted in a single-labeled fragment with the sequence: Glu-Val-Ala-Asn-(Pyridoxal-P-Lys)-Val-Gly-Gly-Ile-Tyr.
(20) Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production.
Wile
Definition:
(n.) A trick or stratagem practiced for insnaring or deception; a sly, insidious; artifice; a beguilement; an allurement.
(v. t.) To practice artifice upon; to deceive; to beguile; to allure.
(v. t.) To draw or turn away, as by diversion; to while or while away; to cause to pass pleasantly.
Example Sentences:
(1) Colin Wiles is an independent housing consultant Interested in housing?
(2) It may be this that compels her to view every man she meets as an opportunity to test whether her wiles are still in full working order, probably unconsciously and probably even if they happen to be the partners of her female friends.
(3) Finance minister John Swinney told Good Morning Scotland he still hoped for a breakthrough at "this very, very, very late stage in the process", saying: Everybody is agreed that this plant has a strong future with the necessary investment and that is why the Scottish Government is wiling to be a player in that.
(4) Extracted from Our People by Iain Banks, from Generation Palestine: Voices from the Boycott, Divestment and Sanctions Movement, edited by Rich Wiles, published by Pluto Press.
(5) But it does explain what might otherwise seem puzzling, that the many Evangelicals among them are perfectly wiling to overlook every transgression in Trump’s past and every crudeness and cruelty in his present conduct, and also to forgive in anticipation whatever future sin might be entailed in breaking up immigrant families or fomenting conflict abroad.
(6) We also do this with actors, comedians and musicians, because we are wiling to accept the “bad boy” persona as part of the act.
(7) After an arduous journey, usually through Thailand and the jungles of Malaysia and Indonesia, they may end up in Puncak wiling away the time, bemoaning the UNHCR and listless days, playing soccer, and swapping stories of ingenious detention escapes.
(8) In their dreams (and in their long lunches with accountants and investors) the people farmers spin a trance-like spiel about a huge cohort of baby boomers soon to reach retirement, empty nesters without responsibilities, eager to wile away their twilight years in glorious consumption, placidly awaiting the dying of the light.
(9) When Warner had 89, Prior missed a second stumping off Swann, who used all his wiles to try to keep things in check, and was a strong contributing factor to Alastair Cook missing a catch, offered by the left-hander Rogers, wide to his right hand at first slip, that a confident keeper would have taken.
(10) Bayer Leverkusen beat Leicester City in race to sign Charles Aránguiz Read more Wolfsburg have so far insisted that they are not interested in selling a player signed last January from Chelsea for £18m, although it is understood that they would be wiling to do business at around £50m.
(11) His skill, wile and connections were insufficient, however, to allow him to survive indefinitely.
(12) "I don't blame the media and the Labour front bench for talking about U-turns but actually if more ministers were wiling to put forward proposals and then alter them in the light of evidence that came forth we'd actually have better government."
(13) Tripoli is an exception to this rule because the Lebanese disease of neglect of more distant regions has left the city captive to the wiles of radical Sunni groups and jihadists.
(14) The size and the extent of foliation of the chimeric cerebella were intermediate between wile-type and homozygous Staggerer.
(15) Wile pressor and reflex bradycardic responses to angiotensin II were not altered by prazosin, reflex tachycardia produced produced by histamine and acetylcholine were significantly attenuated by prazosin.
(16) Clegg will leave Brighton aware that his apology on tuition fees has not led to an immediate lift in his poll standing, but aware that most senior figures are wiling him to take the party into the next election, and broadly happy with his positioning of the party at the centre of the political spectrum.
(17) One depicted him as the Road Runner, Bartra the Wile E Coyote trailing in his wake.
(18) Charities are especially vulnerable – perhaps more so than businesses – to the wiles and charms of the next celebrity savior.
(19) One patient had a spontaneous remission during pregnancy wile taking propranolol.
(20) Stiviano's court filing rejected the idea that her “feminine wiles … overpowered the iron will of Donald T Sterling who is well known as one of the most shrewd businessmen in the world”.