(a.) Not mortal; exempt from liability to die; undying; imperishable; lasting forever; having unlimited, or eternal, existance.
(a.) Connected with, or pertaining to immortability.
(a.) Destined to live in all ages of this world; abiding; exempt from oblivion; imperishable; as, immortal fame.
(a.) Great; excessive; grievous.
(n.) One who will never cease to be; one exempt from death, decay, or annihilation.
Example Sentences:
(1) In keratinocyte lines immortalized by E7 alone, the p53 half-life was found to be similar to that in non-transformed cells; however, it decreased to approximately 1 h following supertransfection of an E6 gene.
(2) This has been accomplished by insertion of a desired gene into a pre-existing immortal cell or by immortalizing primary cells.
(3) The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
(4) The large T antigen from both of these viruses can immortalize primary rat embryo fibroblasts.
(5) Normal and E1A-immortalized rat fetal intestinal epithelial SLC-11 cells were compared for the characteristics of the 35S-labeled proteoglycans isolated from their cell-associated and secreted fractions.
(6) Hybrids obtained following fusion of normal human diploid fibroblasts with different immortal human cell lines exhibited limited division potential.
(7) Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat.
(8) Significantly, their derivation demonstrates the feasibility of immortalizing differentiated neurons by targeting tumorigenesis in transgenic mice to specific neurons of the CNS.
(9) We report on the use of human B lymphocytes immortalized by the Epstein-Barr virus (EBV) as targets for transformation by the c-Ha-ras oncogene of bladder carcinoma cells T24.
(10) Mutagenesis of a diploid human fibroblast strain, KD, with the chemical carcinogen 4 nitroquinolin-1-oxide led to the isolation of stably immortalized neoplastic substrains.
(11) Spontaneous outgrowth of immortalized Epstein-Barr virus (EBV) infected B-cell clones will occur from cultures of peripheral blood mononuclear cells (PBMNCs) of some persons with a history of EBV infection.
(12) We have analyzed the antisperm antibody production of autoimmunized male subjects using Epstein-Barr virus (EBV) immortalization of B lymphocytes.
(13) We suggest that the temporal pattern of HSP70 expression during S phase, the nuclear localization, and activation by trans-acting immortalizing proteins indicate a role for HSP70 in the nucleus of replicating cells.
(14) We have previously reported that adenovirus E1a mutants lacking the C-terminal 61 or 67 amino acids were severely defective in immortalization, but cooperated more efficiently (than wt E1a) with activated T24 ras oncogene in transformation of primary rat kidney (BRK) cells (Subramanian et al., 1989; Oncogene, 4:415-420).
(15) Diazepam and medazepam exposure of immortal and low passage number cells resulted in the formation of monopolar mitotic spindles and subsequent metaphase arrest.
(16) In order to elucidate the role of c-myc oncogene activation in B cell malignancy, the phenotypic changes caused by the expression of c-myc oncogenes in human B lymphoblastoid cells immortalized by Epstein-Barr virus were analyzed.
(17) In contrast, we detected no immortalized colonies when we transfected the cells with DNA of five other early-region deletion mutants that do not make stable truncated forms of T antigen.
(18) Celebrities from Justin Bieber to Spike Lee were on hand for the opening of a spectacle that mixes circus tricks with the music of the late King of Pop – a pairing that has already proved lucrative for Cirque on the road with the arena show, Michael Jackson: The Immortal World Tour .
(19) Unlike the mitogen-stimulated Schwann cells, whose proliferation could be inhibited completely, the immortalized and transformed Schwann cell types were nearly unresponsive to the antiproliferative activity.
(20) After dexamethasone removal, immortal cells divided once or twice and then accumulated in G1.
Imperishable
Definition:
(a.) Not perishable; not subject to decay; indestructible; enduring permanently; as, an imperishable monument; imperishable renown.
Example Sentences:
(1) But, if Tynan's screen output was small, his writing on film is imperishable.
(2) And they were the inheritors of an imperishable Labour movement tradition.
(3) His contribution to the music community is imperishable,” managing director Rory Jeffes said.
(4) But in the desire to maintain the orthodoxies of the day (which must always pass as imperishable truths), instead of reaffirming the common wisdom, the disseminators of (fixed) ideas have been in danger of defeating their own purpose.
(5) Perishable, it attempts to arrogate to itself the prerogative of imperishable time, of separating good books from bad."
(6) It was the cause not very célèbre which not only resulted in an unlikely and humdrum Czechoslovakian clay-courter Jan Kodes being elevated into the imperishable pantheon of Wimbledon champions but gave the OK for a large and itinerant bunch of professional tennis players to bond themselves into the richest group of travelling sportsmen on the planet, which they remain.
(7) Nevertheless, Bowie persevered, moving to New York even while songs as imperishable as Rebel Rebel were missing the US top 40 (though scoring at home in the UK), and in 1974 embarking on his Diamond Dogs tour, a massively theatrical undertaking that traversed America without going to Europe at all.
(8) In an essay celebrating the award, the critic Elaine Showalter acknowledged him as an artist who "changed imperishably the way we see and understand the world".
(9) The music, it seems, is imperishable, even if the drama should be treated more carefully.
(10) The book contains dozens of imperishable phrases and judgments, but few stick in the mind like the opening of his Wilder demolition: "Billy Wilder is too cynical to believe even his own cynicism."
(11) The British army cameramen also filmed the arrival of a mobile bath unit, and it is here, as the women survivors re-encounter warm water, that the film imperishably supplies the idea that, in spite of man-made horror, life somehow remains a blessing.
(12) I grew up playing beach soccer with all my buddies,” said Hejduk, a midfielder with 85 US caps who grew up nearby in Cardiff-by-the-Sea and has the southern Californian aura and vocabulary of Jeff Spicoli, Sean Penn’s imperishable character from the 1982 film Fast Times at Ridgemont High.
(13) Once again it is demonstrated that people do not love their chains or their jailers, and that the aspiration for a civilised life, that "universal eligibility to be noble," as Saul Bellow's Augie March so imperishably phrases it, is proper and common to all.
(14) This from a man, as she noted, who had written more lovingly of the ditches and the daisies and the ruinstrewn land “with a beautiful and imperishable loneliness”.