(a.) Not mortal; exempt from liability to die; undying; imperishable; lasting forever; having unlimited, or eternal, existance.
(a.) Connected with, or pertaining to immortability.
(a.) Destined to live in all ages of this world; abiding; exempt from oblivion; imperishable; as, immortal fame.
(a.) Great; excessive; grievous.
(n.) One who will never cease to be; one exempt from death, decay, or annihilation.
Example Sentences:
(1) In keratinocyte lines immortalized by E7 alone, the p53 half-life was found to be similar to that in non-transformed cells; however, it decreased to approximately 1 h following supertransfection of an E6 gene.
(2) This has been accomplished by insertion of a desired gene into a pre-existing immortal cell or by immortalizing primary cells.
(3) The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
(4) The large T antigen from both of these viruses can immortalize primary rat embryo fibroblasts.
(5) Normal and E1A-immortalized rat fetal intestinal epithelial SLC-11 cells were compared for the characteristics of the 35S-labeled proteoglycans isolated from their cell-associated and secreted fractions.
(6) Hybrids obtained following fusion of normal human diploid fibroblasts with different immortal human cell lines exhibited limited division potential.
(7) Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat.
(8) Significantly, their derivation demonstrates the feasibility of immortalizing differentiated neurons by targeting tumorigenesis in transgenic mice to specific neurons of the CNS.
(9) We report on the use of human B lymphocytes immortalized by the Epstein-Barr virus (EBV) as targets for transformation by the c-Ha-ras oncogene of bladder carcinoma cells T24.
(10) Mutagenesis of a diploid human fibroblast strain, KD, with the chemical carcinogen 4 nitroquinolin-1-oxide led to the isolation of stably immortalized neoplastic substrains.
(11) Spontaneous outgrowth of immortalized Epstein-Barr virus (EBV) infected B-cell clones will occur from cultures of peripheral blood mononuclear cells (PBMNCs) of some persons with a history of EBV infection.
(12) We have analyzed the antisperm antibody production of autoimmunized male subjects using Epstein-Barr virus (EBV) immortalization of B lymphocytes.
(13) We suggest that the temporal pattern of HSP70 expression during S phase, the nuclear localization, and activation by trans-acting immortalizing proteins indicate a role for HSP70 in the nucleus of replicating cells.
(14) We have previously reported that adenovirus E1a mutants lacking the C-terminal 61 or 67 amino acids were severely defective in immortalization, but cooperated more efficiently (than wt E1a) with activated T24 ras oncogene in transformation of primary rat kidney (BRK) cells (Subramanian et al., 1989; Oncogene, 4:415-420).
(15) Diazepam and medazepam exposure of immortal and low passage number cells resulted in the formation of monopolar mitotic spindles and subsequent metaphase arrest.
(16) In order to elucidate the role of c-myc oncogene activation in B cell malignancy, the phenotypic changes caused by the expression of c-myc oncogenes in human B lymphoblastoid cells immortalized by Epstein-Barr virus were analyzed.
(17) In contrast, we detected no immortalized colonies when we transfected the cells with DNA of five other early-region deletion mutants that do not make stable truncated forms of T antigen.
(18) Celebrities from Justin Bieber to Spike Lee were on hand for the opening of a spectacle that mixes circus tricks with the music of the late King of Pop – a pairing that has already proved lucrative for Cirque on the road with the arena show, Michael Jackson: The Immortal World Tour .
(19) Unlike the mitogen-stimulated Schwann cells, whose proliferation could be inhibited completely, the immortalized and transformed Schwann cell types were nearly unresponsive to the antiproliferative activity.
(20) After dexamethasone removal, immortal cells divided once or twice and then accumulated in G1.
Merit
Definition:
(n.) The quality or state of deserving well or ill; desert.
(n.) Esp. in a good sense: The quality or state of deserving well; worth; excellence.
(n.) Reward deserved; any mark or token of excellence or approbation; as, his teacher gave him ten merits.
(n.) To earn by service or performance; to have a right to claim as reward; to deserve; sometimes, to deserve in a bad sense; as, to merit punishment.
(n.) To reward.
(v. i.) To acquire desert; to gain value; to receive benefit; to profit.
Example Sentences:
(1) after operation for hip fracture, and merits assessment in other high-risk groups of patients.
(2) Originally from Pyongyang, the tour guide explains that a “merited artist” from Mansudae, North Korea’s biggest art studio in Pyongyang, was responsible for the main piece, but that it took 63 artists almost two years to complete.
(3) The concept of almost total breast biopsy has great merit in the discovery of occult carcinoma.
(4) A new figure of merit, the limit of identification, is introduced.
(5) An untiring advocate of the joys and merits of his adopted home county, Bradbury figured Norfolk as a place of writing parsons, farmer-writers and sensitive poets: John Skelton, Rider Haggard, John Middleton Murry, William Cowper, George MacBeth, George Szirtes.
(6) The results of this study, combined with those of previous studies, suggest that factor VII may be a useful additional marker of the risk for ischemic heart disease and merits further investigation.
(7) Patients with normal blood lipid livel merit special attention.
(8) Response to norepinephrine was 15, 20, 18, and 15% greater in high genetic than low genetic merit heifers and response to epinephrine was 12, 20, 14, and 50% greater in high genetic than low genetic merit heifers at 30, 60, 180, and 349 d postpartum.
(9) Since no evaluation of the relative merits of electro and chemical cautery has been reported, a prospective randomized study was conducted to assess the effectiveness of electro-cautery and cautery with silver nitrate.
(10) The finding is at variance with others that ascribe haemostatic changes observed to increased oestrogen content in a given pill formulation and so merits confirmation in a larger study.
(11) The surest way for either side to capture the mood of a cash-strapped country would be to give ground on those of their demands which have least merit.
(12) Frequency of sensitivity to foods, preservatives, colouring agents, medical substances, principally shown by provocation tests (the latter present a considerable interest, and merit frequent use); importance of bacterian, mycotic, parasitic origins; little importance of atopy; frequency of minor psychogenic disorders.
(13) The merits of formaldehyde, formaldehyde-glutaraldehyde combinations, and glutaraldehyde in phosphate buffers have been compared as fixatives that will give easy and satisfactory preservation of tissues for routine automated histologic processing and yet keep them suitable for electron microscopical studies after prolonged storage at room temperature.
(14) In the late post-operative period these patients developed complications which merited a surgical reintervention.
(15) Each of the five hospitals denied the doctors privileges without reaching the merits of the doctors' qualifications.
(16) However, submucosal resection of the septum is a rapid, but traumatic surgical method, which has its merits in duration and tradition.
(17) To assess quantitatively the merits of internal standardization, an amino acid mixture of known composition has been analyzed by conventional automated amino acid analysis before and after being subjected to total acid hydrolysis.
(18) Uefa has said it is open to proposals about the future of the competition, amid disquiet from clubs outside England about the spending power of Premier League clubs in the wake of their £8.3bn TV deal, but is expected to strongly resist any move to propose qualification should be on anything other than merit.
(19) Assumptions, bases for choice, and relative merits of these two modeling strategies are discussed.
(20) The increased frequency during the initial stage of the endoscopy, which may assume an already dangerous dimension for patients with coronary heart disease, merits particular attention.