(a.) Not mortal; exempt from liability to die; undying; imperishable; lasting forever; having unlimited, or eternal, existance.
(a.) Connected with, or pertaining to immortability.
(a.) Destined to live in all ages of this world; abiding; exempt from oblivion; imperishable; as, immortal fame.
(a.) Great; excessive; grievous.
(n.) One who will never cease to be; one exempt from death, decay, or annihilation.
Example Sentences:
(1) In keratinocyte lines immortalized by E7 alone, the p53 half-life was found to be similar to that in non-transformed cells; however, it decreased to approximately 1 h following supertransfection of an E6 gene.
(2) This has been accomplished by insertion of a desired gene into a pre-existing immortal cell or by immortalizing primary cells.
(3) The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
(4) The large T antigen from both of these viruses can immortalize primary rat embryo fibroblasts.
(5) Normal and E1A-immortalized rat fetal intestinal epithelial SLC-11 cells were compared for the characteristics of the 35S-labeled proteoglycans isolated from their cell-associated and secreted fractions.
(6) Hybrids obtained following fusion of normal human diploid fibroblasts with different immortal human cell lines exhibited limited division potential.
(7) Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat.
(8) Significantly, their derivation demonstrates the feasibility of immortalizing differentiated neurons by targeting tumorigenesis in transgenic mice to specific neurons of the CNS.
(9) We report on the use of human B lymphocytes immortalized by the Epstein-Barr virus (EBV) as targets for transformation by the c-Ha-ras oncogene of bladder carcinoma cells T24.
(10) Mutagenesis of a diploid human fibroblast strain, KD, with the chemical carcinogen 4 nitroquinolin-1-oxide led to the isolation of stably immortalized neoplastic substrains.
(11) Spontaneous outgrowth of immortalized Epstein-Barr virus (EBV) infected B-cell clones will occur from cultures of peripheral blood mononuclear cells (PBMNCs) of some persons with a history of EBV infection.
(12) We have analyzed the antisperm antibody production of autoimmunized male subjects using Epstein-Barr virus (EBV) immortalization of B lymphocytes.
(13) We suggest that the temporal pattern of HSP70 expression during S phase, the nuclear localization, and activation by trans-acting immortalizing proteins indicate a role for HSP70 in the nucleus of replicating cells.
(14) We have previously reported that adenovirus E1a mutants lacking the C-terminal 61 or 67 amino acids were severely defective in immortalization, but cooperated more efficiently (than wt E1a) with activated T24 ras oncogene in transformation of primary rat kidney (BRK) cells (Subramanian et al., 1989; Oncogene, 4:415-420).
(15) Diazepam and medazepam exposure of immortal and low passage number cells resulted in the formation of monopolar mitotic spindles and subsequent metaphase arrest.
(16) In order to elucidate the role of c-myc oncogene activation in B cell malignancy, the phenotypic changes caused by the expression of c-myc oncogenes in human B lymphoblastoid cells immortalized by Epstein-Barr virus were analyzed.
(17) In contrast, we detected no immortalized colonies when we transfected the cells with DNA of five other early-region deletion mutants that do not make stable truncated forms of T antigen.
(18) Celebrities from Justin Bieber to Spike Lee were on hand for the opening of a spectacle that mixes circus tricks with the music of the late King of Pop – a pairing that has already proved lucrative for Cirque on the road with the arena show, Michael Jackson: The Immortal World Tour .
(19) Unlike the mitogen-stimulated Schwann cells, whose proliferation could be inhibited completely, the immortalized and transformed Schwann cell types were nearly unresponsive to the antiproliferative activity.
(20) After dexamethasone removal, immortal cells divided once or twice and then accumulated in G1.
Perpetual
Definition:
(a.) Neverceasing; continuing forever or for an unlimited time; unfailing; everlasting; continuous.
Example Sentences:
(1) If there is a will to use primary Care centres for effective preventive action in the population as a whole, motivation of the professionals involved and organisational changes will be necessary so as not to perpetuate the law of inverse care.
(2) We speculate that intestinal injury may also induce or perpetuate arthritis by systemic distribution of inflammatory mediators produced by intestinal immune effector cells.
(3) These findings suggest that community differences in levels of violence are perpetuated as Zapotec children learn community-appropriate patterns for expressing aggression and continue to express these patterns as adults.
(4) Post-labeling addition of 1 mM caffeine increased perpetuated blocks to a frequency of about 10% of the initial number of dimers in 4 h in XP16KO-II cells, but not in XP16KO-I and normal cells.
(5) This phenomenon may be of significance in the perpetuation of the disease.
(6) Trierweiler has broken a fundamental principle of French political life, an unwritten law inherited from the Ancien Régime and perpetuated by France's revolutionary nomenklatura, that the private life – and by that I mean sex life – of a public figure must remain inviolable.
(7) The ways in which medical personnel have opposed the political abuse of medicine is explored by a brief review of the opposition of Chilean doctors to torture, the involvement of South African doctors in opposing the abuse of health services in perpetuating apartheid, and the growing medical movement in opposition to nuclear war.
(8) Utilization data are known to be strongly influenced by the supply of facilities, particularly beds; unless this can be taken into account there is a likelihood that historical patterns will simply be perpetuated whether justified or not.
(9) Health care professionals hold attitudes toward persons with disabilities that are similar to those of society as a whole, and they may be actual perpetuators of this limiting practice.
(10) Moreover, genetics textbooks consistently employ confused or misleading definitions of the concept of heritability that, together with the reporting of discredited data, perpetuate a fundamentally inaccurate understanding of the genetics of intelligence.
(11) Even the most popular Shia cleric, Sayyed Mohammed Fadlallah , a man who has deeply affected the thinking of key Hezbollah leaders and cadres since the party's inception, now says in no uncertain terms that Shias and the country as a whole want to see, and should see, a strong Lebanese army as the nation's sole protector; and that the perpetually unstable confessional system must be ended as soon as possible.
(12) When this parliament votes for another referendum as it inevitably will, thanks to the perpetual crutch that the Greens provide, let’s not pretend it reflects the will of the Scottish people, because it doesn’t.
(13) The study has shown that: There is a significant increase in the severity of gingivitis during pregnancy; The gingival changes progressively increase during the course of pregnancy; The gingival changes are more marked than the periodontal changes seen during pregnancy (increase in periodontal disease was seen in only a limited number of cases); There was an appreciable increase in the calculus and debris deposits in the pregnant as compared to the nonpregnant women; Increase in the calculus and debris deposits was apparent in all the trimesters of pregnancy; Gingival changes showed a greater correlation with the calculus and the debris index in the pregnant than in the nonpregnant women; The role of the irritant oral deposits either as a precipitating or perpetuating factor in the genesis of gingivitis during pregnancy can not be excluded.
(14) Also in the Lords amongst the phalanx of red leather benches is a solitary seat curbed by an armrest provided for a perpetually drunken Lord (hence the saying?)
(15) In addition, TNF is produced and cleared from the blood-stream within a short period of time after an LPS stimulus, suggesting that TNF sets into motion a chain of events that may be self-perpetuating even in the absence of further TNF stimulus.
(16) One of the most tragic aspects of child abuse and neglect is that it is so often perpetuated from one generation to another.
(17) Yet, for many reasons, clinicians tend to resist rapid changes and perpetuate antiquated practices, diagnostic strategies, and clinical policies.
(18) The role of Ixodes ricinus and possible other vectors in perpetuating transmission of the European infection remains to be defined.
(19) It is caused by an intense, self-perpetuating process of clot-formation and lysis within the abnormal vascular channels of the haemangioma, and results in consumption of platelets and clotting factors.
(20) The central role of platelet-vessel wall interaction in the initiation and perpetuation of this process is well established.