(a.) Not mortal; exempt from liability to die; undying; imperishable; lasting forever; having unlimited, or eternal, existance.
(a.) Connected with, or pertaining to immortability.
(a.) Destined to live in all ages of this world; abiding; exempt from oblivion; imperishable; as, immortal fame.
(a.) Great; excessive; grievous.
(n.) One who will never cease to be; one exempt from death, decay, or annihilation.
Example Sentences:
(1) In keratinocyte lines immortalized by E7 alone, the p53 half-life was found to be similar to that in non-transformed cells; however, it decreased to approximately 1 h following supertransfection of an E6 gene.
(2) This has been accomplished by insertion of a desired gene into a pre-existing immortal cell or by immortalizing primary cells.
(3) The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
(4) The large T antigen from both of these viruses can immortalize primary rat embryo fibroblasts.
(5) Normal and E1A-immortalized rat fetal intestinal epithelial SLC-11 cells were compared for the characteristics of the 35S-labeled proteoglycans isolated from their cell-associated and secreted fractions.
(6) Hybrids obtained following fusion of normal human diploid fibroblasts with different immortal human cell lines exhibited limited division potential.
(7) Cell lines established directly from adult T-cell leukemia-lymphoma patients or immortalized by human T-cell leukemia virus type I (HTLV-I) in vitro that do not produce complete HTLV virions were characterized both for the content of viral proteins and for the presence of trans-acting factors activating gene expression under the control of the HTLV long terminal repeat.
(8) Significantly, their derivation demonstrates the feasibility of immortalizing differentiated neurons by targeting tumorigenesis in transgenic mice to specific neurons of the CNS.
(9) We report on the use of human B lymphocytes immortalized by the Epstein-Barr virus (EBV) as targets for transformation by the c-Ha-ras oncogene of bladder carcinoma cells T24.
(10) Mutagenesis of a diploid human fibroblast strain, KD, with the chemical carcinogen 4 nitroquinolin-1-oxide led to the isolation of stably immortalized neoplastic substrains.
(11) Spontaneous outgrowth of immortalized Epstein-Barr virus (EBV) infected B-cell clones will occur from cultures of peripheral blood mononuclear cells (PBMNCs) of some persons with a history of EBV infection.
(12) We have analyzed the antisperm antibody production of autoimmunized male subjects using Epstein-Barr virus (EBV) immortalization of B lymphocytes.
(13) We suggest that the temporal pattern of HSP70 expression during S phase, the nuclear localization, and activation by trans-acting immortalizing proteins indicate a role for HSP70 in the nucleus of replicating cells.
(14) We have previously reported that adenovirus E1a mutants lacking the C-terminal 61 or 67 amino acids were severely defective in immortalization, but cooperated more efficiently (than wt E1a) with activated T24 ras oncogene in transformation of primary rat kidney (BRK) cells (Subramanian et al., 1989; Oncogene, 4:415-420).
(15) Diazepam and medazepam exposure of immortal and low passage number cells resulted in the formation of monopolar mitotic spindles and subsequent metaphase arrest.
(16) In order to elucidate the role of c-myc oncogene activation in B cell malignancy, the phenotypic changes caused by the expression of c-myc oncogenes in human B lymphoblastoid cells immortalized by Epstein-Barr virus were analyzed.
(17) In contrast, we detected no immortalized colonies when we transfected the cells with DNA of five other early-region deletion mutants that do not make stable truncated forms of T antigen.
(18) Celebrities from Justin Bieber to Spike Lee were on hand for the opening of a spectacle that mixes circus tricks with the music of the late King of Pop – a pairing that has already proved lucrative for Cirque on the road with the arena show, Michael Jackson: The Immortal World Tour .
(19) Unlike the mitogen-stimulated Schwann cells, whose proliferation could be inhibited completely, the immortalized and transformed Schwann cell types were nearly unresponsive to the antiproliferative activity.
(20) After dexamethasone removal, immortal cells divided once or twice and then accumulated in G1.
Timeless
Definition:
(a.) Done at an improper time; unseasonable; untimely.
(a.) Done or occurring before the proper time; premature; immature; as, a timeless grave.
(a.) Having no end; interminable; unending.
Example Sentences:
(1) Some of what I was churned up about seemed only to do with me, and some of it was timeless, a classic midlife shock and recalibration.
(2) Even before she gets to the Timeless premiere, the Mail Online has run two news stories on her that day: the first detailing what she was wearing in the morning, the second furnishing a grateful world with the news that she'd subsequently changed her outfit and taken her sunglasses off.
(3) And anyway, if her fictional world is so timeless, why has it gone in and out of fashion?
(4) His bestselling book is The Annotated Alice, a timeless compendium of footnotes to the two Alice books, and a decade ago he wrote a sequel to The Wizard Of Oz in which Dorothy and friends go to Manhattan.
(5) Scarcely a single witness had seen more than one Velázquez, and many testified to the extraordinary surprise of this one, the face of the long-dead prince flashing up into a timeless present.
(6) The actor's slightly imperious manner and timeless face suited period roles.
(7) One drawback of the timelessness of Bond – maintained by a movie franchise that keeps 007 in a permanent present – is how easy it is to forget that Fleming was writing in, and therefore about, a very specific period.
(8) Playhouse Presents … Timeless is on Thursday 19 June at 9pm on Sky Arts
(9) The Doctors Mayo were strategic thinkers when it came to National Defense, and it is with a feeling of almost haunting prophetic significance to consider their timeless wisdom on preparedness as a means to ensure peace.
(10) In the meantime, its fortunes rest on the British public's insatiable appetite for reality TV shows – and the timeless televisual appeal of dancing dogs.
(11) You might have read a couple of articles in fashion magazines of late attempting to big up the DD look, no doubt with references to denim's "timelessness", "1950s teenage sense of freedom" and, lest we forget, "Americana".
(12) Under marihuana the stories had a timeless, non-narrative quality, with greater discontinuity in thought sequence and more frequent inclusion of contradictory ideas.
(13) A short visit to a medical consulting room as it may have looked one hundred years ago, illustrates some aspects of medical practice of this time, outlines in scraps and fragments an idea of this medicine and tries to encourage reflexions about contemporary and timeless problems of medical practice.
(14) Stores such as Cos for cool, offbeat minimalism or Jane Shepherdson's Whistles, where Celine-style trousers sit alongside timeless workwear, have upped the ante.
(15) Because the terrorists can only succeed if they swell their ranks and alienate America from our allies, and they will never be able to do that if we stay true to who we are; if we forge tough and durable approaches to fighting terrorism that are anchored in our timeless ideals.
(16) Shakespeare refuses to take sides, and that's why it works so timelessly.
(17) The timeless modernity and topicality of Rudolf Virchow's postulations on tumor pathology is based on his general conclusions which as key propositions have retained general validity throughout more than a century.
(18) But she's not bad as the partner of an Iraq-bound soldier in Timeless: perhaps a bit plummier than you might expect a squaddie's wife required to live with her irascible great-grandmother in a tiny house to be, but certainly nothing like the disaster the world has come to expect from supermodels demonstrating their polymath abilities.
(19) "Then you have this classic repertoire of great music that feels like it's coming from this other, timeless place.
(20) This procedure brings forcibly to the fore issues of separation and individuation, in the psychological context of the ultimate termination of life; it counteracts passive, timeless waiting for change to come without the assertion of one's own will and action, and it highlights a variety of ways people characteristically behave with respect to endings.