(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Impish
Definition:
Example Sentences:
(1) And that voice like a whip-crack: impish, transgressive, swooping from a mutter to a scream.
(2) This wasn’t Roberto Carlos defying physics for Real Madrid –but given the impish star on the end of Saturday’s shot, it felt even more improbable.
(3) Their first-half efforts here all lacked direction, as was the case when their impish Spanish midfielder Carles Gil dragged wide just before Hull’s opening goal and when Ashley Westwood clipped a 36th-minute free-kick over the wall, or power on the only occasion they did manage an effort on target when Allan McGregor saved a tepid glancing header from Gabby Agbonlahor.
(4) He was in the original 1965 production of Joe Orton's Loot , playing Hal, the impish hero who hides the proceeds from a robbery in his mother's coffin.
(5) But Winning’s got an attractively impish spirit and there are some spry jokes here.
(6) "I've had my fun," she says the morning after, looking more impish than hungover at the offices of the film's publicist.
(7) France were short of potency until the substitution board came up and Deschamps swapped Giroud for an impish young talent who is full of quick thinking, clever feet and the bright ideas to make something happen.
(8) West Germany bring in two impish schemers, Thomas Hässler and Olaf Thon, for Pierre Littbarski and Uwe Bein.
(9) Almost as soon as two HIV-prevention activists set up outside the pharmacy in the outskirts of Moscow with two huge backpacks of supplies, a skinny young man with mussed hair and an impish grin quickly walked up to them.
(10) The Great British Bake Off’s winning ingredient | Letters Read more Much of the tone of the show – as light and sweet as a sponge – is carried by its presenters, the impish Sue Perkins and Mel Giedroyc, and their end-of-pier, Carry On-style humour.
(11) He can win or lose with the group.” Neymar is remarkably level-headed and he can seem like an impish kid who wants to have fun.
(12) Back in the hotel room, drinking his coconut water, Wood gives an impish grin when I ask if he feels like a survivor.
(13) Another visitor to her flat was Stanislav Markelov, a 34-year-old lawyer with an impish sense of fun, who worked with Estemirova representing Chechen victims.
(14) First there was that leaked poster, which appeared to show the impish, emerald-skinned bomb chucker flying through the skies of Manhattan on his trademark glider.
(15) She wasn’t some two-dimensional figure, but was humanity itself – impish, playful, energetic, determined, vibrant, loving, funny and strong.
(16) Finally she resumes her position on the sofa with Marcel still chuckling impishly under one arm.
(17) The new bantamweight king of the Olympics, whose impish features disguise an iron will, became the team's second gold medallist after Nicola Adams made history in the women's inaugural tournament.
(18) His impish dribbling and ability to pick out a pass could make the difference for West Ham.
(19) Jacob Steinberg It feels harsh in the extreme to overlook Vardy’s goals and assists but I’m going to, simply because few things in life are better than watching an impish winger like Mahrez torment full-backs.
(20) A small boat packed with revellers – notable among them the already familiar, wiry figure of Dizzee Rascal – had sailed up the river, irreverently blasting out the impish Bow teenager's new single Jus' a Rascal, and turning the carefully stage-managed finale of Blaine's "Above The Below" into an impromptu video shoot.