(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Limp
Definition:
(v. i.) To halt; to walk lamely. Also used figuratively.
(n.) A halt; the act of limping.
(n.) A scraper for removing poor ore or refuse from the sieve.
(a.) Flaccid; flabby, as flesh.
(a.) Lacking stiffness; flimsy; as, a limp cravat.
Example Sentences:
(1) As it was, Labour limped in seven points and nearly two million votes behind the Conservatives because older cohorts of the electorate leant heavily to the Tories and grandpa and grandma turned up at the polling stations in the largest numbers.
(2) Everton ended with 10 men after Seamus Coleman limped off with all three substitutes deployed but there was no late flourish from a visiting team who, with Fernando replacing Kevin De Bruyne after the Irish defender’s departure, appeared content to settle for 1-2.
(3) He limped around in the beginning but the injury worsened.
(4) An actor dressed like one of the polar bears that figure in Coke ads limped up, wearing a prosthesis on one paw, a dialysis bag and tubing.
(5) Despite the 2 operations and extensive medical treatment with vasodilators, anticoagulants, and other medication, the pain and limp persisted and a cutaneous necrosis of the 1st and 5th left toes was observed.
(7) An obese man with a withered leg limps down Tollcross Road, eating pizza from a cardboard box.
(8) The Bruins, on the other hand, limped into the playoffs, with everyone wondering where their firepower had gone.
(9) More here: UK regulator urges banks to speed up swaps mis-selling compensation 8.40am GMT More reaction to the decision to send riot police to evict people from the offices of Greece's former state broadcaster this morning , starting with journalist Nick Malkoutzis: Nick Malkoutzis (@NickMalkoutzis) 5 mths after flicking switch on public broadcaster ERT, gov't tries to settle issue by sending riot police to remove remaining staff #Greece November 7, 2013 Nick Malkoutzis (@NickMalkoutzis) While #ERT will be off air for good after police intervention, the stain of how its closure has been handled won't wash away easily #Greece November 7, 2013 Lady Mondegreen (@amaenad) Like a mean stupid dog appeasing a cruel master, the Greek government wants to lay ERT's limp body at the troika's feet.
(10) The girl's mother, who I learned later, had recently arrived in Danané with her daughter after escaping the fighting in Abidjan, lifted the limp body and carried it out of the house to where we were parked.
(11) Their composure was shattered from the moment Alex McCarthy gifted the visitors an equaliser, all authority wrested away in the blink of an eye and Liverpool , suddenly focused where previously they had been limp and ineffective, the more persuasive threat in what time that remained.
(12) This team may have limped to the 50-point mark with their draw against the champions, but they have been pining for the end of this campaign for months.
(13) "It is spring, moonless night in the small town, starless and bible-black, the cobblestreets silent and the hunched, courters'-and-rabbits' wood limping invisible down to the sloeblack, slow, black, crowblack, fishingboatbobbing sea."
(14) If that happened, he could get up and limp across the street to the safety of the Indymedia centre, where he had spent the past three days filing reports on the G8 summit and on its violent policing.
(15) To determine whether limping is associated with decreased bone mineralization, the trabecular and integral bone densities (BDs) of 18 Caucasian children exhibiting computed tomographic evidence of tarsal coalition (14 boys, 4 girls, aged 9 years, 5 months to 16 years, 3 months) were compared with those of an age- and sex-matched control group.
(16) By then Wenger's frown lines had deepened in the wake of some heavy limping on Mikel Arteta's part.
(17) Today, he suffers from partial paralysis on the left side of his body, and has a limp and limited use his left arm.
(18) An analysis of the incidence and significance of leg shortening, limping, and abductor lurch is presented and some observations made on trochanteric overgrowth and the effect of surgery on the rate of femoral head reconstitution.
(19) In cultured cells, the general immunostaining patterns observed in vivo were maintained during the duration of the primary cultures for all five LIMPs.
(20) For Manchester City, Yaya Toure will return to their starting line-up, having been suspended for their match against Bayern Munich, but Micah Richards will miss today's game after limping off against Bayern with a hamstring injury.