(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Malevolent
Definition:
(a.) Wishing evil; disposed to injure others; rejoicing in another's misfortune.
Example Sentences:
(1) Facebook Twitter Pinterest Trump ‘sways malevolently’ behind Hillary Clinton Instead, he began the night by assembling a group of women in a press conference to revisit alleged sexual assaults by Bill Clinton, before confronting his opponent hardest on her private email server.
(2) It is the sort of malevolent onslaught that has caused many hardened media pundits to quake.
(3) The self-serving transparency of her malevolence seemed so obvious I didn’t even hire a lawyer to defend myself.” He took a lie detector and passed, Allen said, but Mia Farrow declined to do so.
(4) To study malevolent representations, earliest memories were reliably coded on scales of affect tone.
(5) To his enemies, Sechin is a malevolent figure, a Kremlin grey cardinal crossed with the Big Bad Wolf.
(6) These statements reveal outrageous malevolence regarding the values that define this European Union and, if pronounced by an official representative of the United States, they would have the potential to undermine seriously the transatlantic relationship that has, for the past 70 years, essentially contributed to peace, stability and prosperity on our continent.” Trump's focus on UK trade could sideline EU, Democrats fear Read more A letter from the leader of the Socialists and Democrats group, Gianni Pittella, describes Malloch’s statements as “shocking” and urges the EU institutions to treat him as a “persona non grata”.
(7) Health care providers must too often stand by helplessly as disinterested or malevolent relatives make these decisions, while caring, competent non-relatives are shut out of the decision-making process.
(8) Goodness knows how it would have turned out if I had played the part, but I would have been malevolent in a very different way.
(9) Devout Muslims consider it a sacrilege for infidels to depose a Muslim tyrant and occupy Muslim lands — no matter how well intentioned the infidels or malevolent the tyrant.
(10) Either that or they're twisting his injured leg malevolently as a form of torutre.
(11) Malevolent object relations as well as splitting have long been considered by psychodynamic theorists as central features of borderline personality disorder.
(12) Half of the indigenous faith healers and more than half of the babalawos we interviewed attributed non-congenital deafness to malevolent forces, while only 12.5% of the herbalists made this attribution.
(13) He added: "We have a solid duty and a moral imperative to deny Iran's leaders the means to follow through on their malevolent intentions."
(14) Specifically, borderlines tend to understand human action as more highly motivated and human interaction as more malevolent in nature than do either depressive or normals.
(15) Nor, after the ban, it must be said, was Ali’s passing, nasty and vindictive side ever again in evidence, such as when he bullyingly and hurtfully “carried” the hapless, injured Patterson in 1965, or malevolently taunted to painful humiliation for the full 15 rounds Ernie Terrell, who had addressed Ali as Clay at the weigh-in at Houston in 1967.
(16) There was no rhyme, reason or research to suggest a fifth of disabled people should do without help, but plenty of malevolent accusations poured out from Duncan Smith's team.
(17) Manfred Weber, leader of the centre-right EPP and an ally of the German chancellor, Angela Merkel, and Guy Verhofstadt, who leads the liberal ALDE group, accused Malloch of “outrageous malevolence” towards “the values that define this European Union”.
(18) We should recognise his concerns and frame it in terms of a misunderstanding with no malevolent intent and that we will make sure there is no recurrence.
(19) While Dylan, her ex-protege, ex-boyfriend and the man with whom she will forever be linked, looks more like a malevolent troll every year, Baez, at 65, is radiant.
(20) Click here for the Paddington trailer There was a swift online reaction to the still image from the film pictured above, in which Paddington looks less like the harmlessly bumbling bear of Michael Bond's books and more a malevolent creature, disturbingly sentient enough to dress itself in a duffel coat.