(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Mischievous
Definition:
(a.) Causing mischief; harmful; hurtful; -- now often applied where the evil is done carelessly or in sport; as, a mischievous child.
Example Sentences:
(1) The appearance of a band with lean, spiky songs, high cheekbones and excellent trousers was therefore the cause of considerable excitement, to which they mischievously alluded in the title of their debut album, Is This It.
(2) In response, the ANC secretary-general, Gwede Mantashe, said the critics were "mischievous" and the party should be allowed to run its own affairs.
(3) You don't have to be against the minority of SAHMBY (stay-at-home mothers by choice) to consider their involvement in this debate a complete, and sometimes mischievous, distraction.
(4) It hasn’t helped that one mischievous customer appears to have added a crease to the carton on the right to make it look even more like a penis.
(5) "I want to reassure my friend Eduardo that there is no chance of me hanging on to the Olympic flag at the closing ceremony", joked Johnson, before adding mischievously "As protocol demands I will be handing it over to Eduardo — probably."
(6) Three seasons in the media spotlight in Madrid have clearly done him no harm, and when a potentially mischievous question comes along about England temporarily transferring their support to Wales he defuses it politely and diplomatically.
(7) Moir, who has won a British Press Award, made a statement defending her column late on Friday, saying it was not her intention to offend, blaming a "heavily orchestrated internet campaign" for the furore and adding that it was "mischievous in the extreme to suggest that my article has homophobic and bigoted undertones".
(8) The final seconds of the movie are the most memorable, in which Smokey assures Big Worm he’s going to rehab, before hanging up the phone and lighting a joint with a mischievous grin to the camera.
(9) These fairies have sharp, mischievous features, quite different from the later fairies of Bethlem.
(10) Prime ministers are very useful to a treasurer,” Keating said mischievously, and Hawke and I had a great relationship until he “produced a nasty little book”.
(11) The first point to note is that Sally's spirit guides were in a particularly mischievous mood during the reading, because they persuaded Sally to make statements such as: Sally: Is there the name Robyn?
(12) What is not so well known is his mischievous streak.
(13) The moderator of the conference demanded that Aydin switch to Turkish; a fellow Kurd came mischievously onto the platform to translate.
(14) Richard E Grant and Anna Chancellor join the cast, with Grant playing a guest of the Granthams and Chancellor the mischievous Lady Anstruther.
(15) At the time, a friend of Rennard told the BBC the "shocking and mischievous" leak was "in total defiance of fair process" and had caused great distress to the peer.
(16) Outside of the octagon, Bisping possesses the demeanour of an oversized Ricky Hatton - all mischievous grins, wisecracks and gentle ribbing of his sparring partners.
(17) Updated at 10.58am BST 10.55am BST Is the chancellor being too dramatic by declaring this morning that NO Help To Buy mortgages can be granted at more than 4.5 times the borrowers' income, asks a mischievous Robert Peston.
(18) He bubbles with mischievous excitement, recounting the range of thugs, creeps and gorgeous males who fell under his spell ("It was like a conduit had opened").
(19) Raphael wrote: “We believe our audience is sophisticated enough to accept a broad range of viewpoints, and we are loth to censor or avoid significant works of literature because they might be controversial.” BBC Radio 4 Publicity said online: “In Hilary Mantel’s mischievous story, a knock at the door announces an unexpected visitor who has plans to alter the course of history as people know it.
(20) For his part, Mr Taleb may have felt mischievously reported.