(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Pixie
Definition:
(n.) An old English name for a fairy; an elf.
(n.) A low creeping evergreen plant (Pyxidanthera barbulata), with mosslike leaves and little white blossoms, found in New Jersey and southward, where it flowers in earliest spring.
Example Sentences:
(1) I resented my own parents on far flimsier grounds (unwillingness to buy me purple suede pixie boots, for instance).
(2) Their European tour , which finishes in London on Monday, is sold out and there seems to be a general consensus that Pixies, who suddenly find themselves with everything to prove, are playing ferociously.
(3) • Black Francis speaks of Kim Deal's departure from the Pixies
(4) We started seriously talking about recording new music about four years ago,” Pixies drummer David Lovering explained.
(5) Aside from asking Essex to "put a ring on it", she'll debut that new pixie cut in the UK.
(6) The rights of women and of minority populations and vulnerable and low-income people are under threat and we must do everything we can to protect these rights and fight for true equality.” Musician Pixie Geldof, writer Stella Duffy, activist Jack Monroe and US rock musician Thurston Moore are supporting the London march, while in the US organisers claim that many of the musicians who have refused to play at Trump’s inauguration will join them.
(7) Scott Morrison says Labor 'selling a unicorn' with negative gearing savings Read more “I can sell them a fantasy or whatever you want to call it, pixie horses, whatever your preferred analogy is, but I’m not going to spin the public a line that there is some simple answer to getting expenditure down,” Morrison told 3AW on Friday.
(8) Whatever they’ve been talking about in public – tax cuts, steel workers’ jobs, unicorns, pixie horses , negative gearing, etc – behind the scenes politicians from all parties have been utterly preoccupied for months with this proposed change.
(9) The inhibition by PIXI of factor XIa-catalyzed activation of factor IX and its capacity to prevent factor XIa inactivation by alpha 1-protease inhibitor, combined with the specificity of PIXI for factor XIa among serine proteases found in blood, suggest a role for PIXI in the regulation of intrinsic coagulation.
(10) He has engineered more than 2,000 records – by bands you mostly won’t have heard of, although a few of them you will, including PJ Harvey, Joanna Newsom, Pixies, Fugazi and that little three-piece out of Seattle, Nirvana .
(11) But unlike, say, Duran Duran or the Pixies, they've never really been away, so there's no opportunity to key into the nostalgia circuit.
(12) pIXY 321 may offer significant clinical advantages over the individual cytokines.
(13) Pixies made me forget I was dressed in a bin-liner I wasn't expecting too much from the Pixies before their second from top slot on the Other stage .
(14) Clockwise from top left: Grimshaw with Kelly Osborne; Sara Cox and Annie Mac at the Brit awards; Queens of Noize DJ Tabitha Denholm; dressed as Lily Allen, off to Mark Ronson’s birthday party; at Amy Winehouse’s funeral; with Henry Holland; Pixie Geldof and Alexa Chung at the NME awards afterparty; predecessor Chris Moyles.
(15) Look, Pixie Geldof has found a big conker made of twigs, and it might have something to do with River Island, and she looks quite pleased .
(16) The full title of this event is the artistic gymnastics, and for 2012 the event seems to want to place the emphasis on art; thus the competitors were played in with a curious acoustic set from singer Pixie Lott, standing in the middle of the floor mat, surrounded by feline acrobats in latex body stockings.
(17) The festival in question, Summer in the City, has officially announced some of its July performers: Pixies and Royal Blood on 10 July, and James with Starsailor on 11 July.
(18) Double dissolution is a 'live option' as Morrison rules out 'pixie horse' tax cuts Read more The Coalition government kept the option of calling a double-dissolution election up its sleeve, he said, and could pull the trigger if the Senate “becomes inoperable”.
(19) Widely read, with a quick wit and sharp intelligence, she was also a devoted partner and mother to her and Geldof's extravagantly-named daughters, Fifi Trixibelle, Peaches and Pixie.
(20) "Today, the thrill and pixie dust of Barack Obama's presidency is gone."