(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Supernatural
Definition:
(a.) Being beyond, or exceeding, the power or laws of nature; miraculous.
Example Sentences:
(1) You can see where the religious meme sprung from: when the world was an inexplicable and scary place, a belief in the supernatural was both comforting and socially adhesive.
(2) American Horror Story is a paean to the supernatural whose greatest purpose is letting washed-up actors and pop stars chew the scenery on the way to winning awards .
(3) There was no relationship between psychoses and supernatural belief types.
(4) Due to the supernatural aura surrounding mental disease, the lack of a sufficient biological basis, and the capacity to reduce civil rights of individuals, psychiatry occupies a special position among the medical disciplines.
(5) He added that the Halloween challenge will become an annual event for psychics and others who claim supernatural abilities.
(6) Their focus on supernatural faith – on healing and speaking in tongues – is shared with LoveBristol, but E 5 put less emphasis on woolly jumpers and green politics and more on slick online videos and social media .
(7) He has described it as "a domestic tragedy with only vaguely supernatural overtones", saying that, "a visceral sceptic such as Kubrick just couldn't grasp the sheer inhuman evil of the Overlook Hotel."
(8) But Thorne’s working life has been spent subverting genres, through his Bafta-winning work on supernatural thriller The Fades and Shane Meadows’s bleak, beautiful coming-of-age miniseries This Is England ’86 and ’88.
(9) It’s thoroughly appropriate that the last large-scale piece he completed was a community and children’s opera, The Hogboon, which will receive its first performance at the Barbican in London in June ; it’s based on an Orkney legend of supernatural beings who inhabit the prehistoric burial mounds that are found all over the islands, and who are entirely benign.
(10) The most relevant results were: the taxonomic determination of 237 vegetal species from which 399 curative products are obtained, in order to combat 57 illnesses, the most frequent of which are those related to the digestive system, the skin, the reproductive system and those of supernatural origin, which can only be treated by the use of plants in special ceremonies known as 'limpias', due to their peculiar condition.
(11) Analysis of the relationship of AIDS to traditional beliefs revealed that AIDS had been integrated into the traditional conceptualization of illness, health practices, and healing, and was attributed to both natural and supernatural causes.
(12) Multi-dimensional scaling analysis shows four clusters of mental distress: a) stress; b) western physiological; c) nonwestern physiological; and d) supernatural.
(13) The Queen is bonded to her country and people by supernatural compact.
(14) Herein lies the danger: it is in the interests of both western powers and Isis to grant this bunch of terrorists an almost supernatural horror.
(15) The movie might not have continued to inspire this level of devotion without its central, unanswerable mystery about the cause of the time loop; other Hollywood fantasies provide explanations for their supernatural events.
(16) Illness and the supernatural world are linked by the concepts of ghosts and Fever, the latter an index of ghost illness, deriving from a supernatural being.
(17) He designed a leaflet titled “Look After Yourself” pointing out clues that might distinguish between a person with supernatural powers and a person who “just appears to have them”.
(18) Illustrated by artists including Breno Tamura, Matt Rosenberg and Gus Storms, it's a supernatural-tinged tale of Mafia intrigue in which the soul of a murdered gangster, Tony Starks (Ghostface's regular alter ego), is bound up in 12 pieces of mystical vinyl.
(19) Breaking Bad and House of Cards are up against two subtitled series, BBC4's Danish political drama import Borgen and The Returned, the French supernatural thriller broadcast by Channel 4, for the international Bafta.
(20) BBC4's documentary about the supernatural on TV, Ghosts in the Machine, was watched by 304,000 between 9pm and 10pm.