(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Troll
Definition:
(n.) A supernatural being, often represented as of diminutive size, but sometimes as a giant, and fabled to inhabit caves, hills, and like places; a witch.
(v. t.) To move circularly or volubly; to roll; to turn.
(v. t.) To send about; to circulate, as a vessel in drinking.
(v. t.) To sing the parts of in succession, as of a round, a catch, and the like; also, to sing loudly or freely.
(v. t.) To angle for with a trolling line, or with a book drawn along the surface of the water; hence, to allure.
(v. t.) To fish in; to seek to catch fish from.
(v. i.) To roll; to run about; to move around; as, to troll in a coach and six.
(v. i.) To move rapidly; to wag.
(v. i.) To take part in trolling a song.
(v. i.) To fish with a rod whose line runs on a reel; also, to fish by drawing the hook through the water.
(n.) The act of moving round; routine; repetition.
(n.) A song the parts of which are sung in succession; a catch; a round.
(n.) A trolley.
Example Sentences:
(1) While the papers in this country and the New Yorker were crowing about how Beard had, through her own gutsy initiative, tamed her trolls, another woman – Anita Sarkeesian, a Canadian-American journalist – was being trolled.
(2) Trolls called Kaepernick racial epithets , after all.
(3) (They also delivered an encouraging decision on patent trolls just this week.)
(4) Asked by a troll how long he planned to “live off” his Olympic success, and if he would ever do anything of consequence again, Rutherford suggested he might become a porn star or dabble in pottery instead.
(5) Academic and TV historian Mary Beard has disclosed her innovative approach to dealing with her vitriolic Twitter trolls – writing them a job reference.
(6) Digital culture has hardly helped, adding revenge porn, trolls and stranger-shaming to the list of uncomfortable modern obstacles.
(7) Facebook Twitter Pinterest John Oliver on Donald Trump: ‘A Klan-backed misogynist internet troll’ Hang on a minute: who am I as a Briton to interfere in the internal affairs of a foreign country?
(8) And I’m sorry, that will come before any internal party-political issue and I think I should be able to adopt that position without being attacked, without being subject to a nasty troll-form of politics.” On Tuesday the prime minister, David Cameron, promised to publish a comprehensive strategy on Syria in the form of a written response to a report by the foreign affairs select committee, which concluded that the government had failed to make the case for extending airstrikes.
(9) Indeed, the internet’s troll culture developed, at least in part, as a response to the inane “participation” offered by online marketers.
(10) Now, some are accustomed to Dawkins being a bit of a troll.
(11) At least that’s what one sewing blogger’s followers decided after an internet troll came out of nowhere to tell her she should “eat less cake”.
(12) The Daily Stormer, a neo-Nazi hate site whose founder organizes harassing “troll storms” of abuse towards political opponents, surpassed the traffic ratings of Stormfront, a more traditional racist site, last July, according to the center’s analysis, becoming the most popular English-language far-right site.
(13) This is the dead centre of troll territory; what they're looking for is that sharp intake of breath; the collective, "How can you say that?"
(14) You should eat less cake’.” In response, Rushmore posted another picture with a defiant message for the troll.
(15) When women can be misogynist trolls, we need a feminist internet | Polly Toynbee Read more “We have got a very real problem with online abuse in this country,” she said.
(16) Mark Warner, the top Democrat on the Senate intelligence committee carrying out a parallel inquiry, has said that at least 1,000 “paid internet trolls working out of a facility in Russia” were pumping anti-Clinton fake news into social media sites during the campaign.
(17) The most widely accepted definition of a troll is a provocateur – someone who says outrageous, extreme or abusive things to elicit a reaction.
(18) Trolls are not often in a rush to discuss their behaviour with a stranger who might spill their darkest deeds to the world.
(19) She admitted getting dates wrong, – giving both trials and the police three separate dates for the visits – but insisted the event, as Trolle later testified, was true.
(20) A variety of different forms of online abuse are highlighted on the site, from trolling (deliberately posting “offensive, upsetting or inflammatory comments online in an attempt to hurt and provoke a response”) to doxxing (publishing personal information about someone, including sex videos and photos, also known as revenge porn) and cyberstalking (“a pattern of online behaviour that is the long-term, intrusive and persistent pursuit of one person by another, making the victim feel frightened and distressed”).