(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Impend
Definition:
(v. t.) To pay.
(v. i.) To hang over; to be suspended above; to threaten frome near at hand; to menace; to be imminent. See Imminent.
Example Sentences:
(1) Asked if France had “jumped the gun and didn’t tell us”, Fox said he was notaware of anyone in government who knew about the impending airstrikes.
(2) Insecure infant attachment at 16 months was associated with maternal perception of overcontrol, depressed mood state, and aversive conditioning to the impending cry in the laboratory task at the 5-month period.
(3) In contrast to other methods (ECG, inspection, auscultation, blood gas analysis), it immediately detects an impending lack of oxygen, whatever its cause.
(4) In grade 1, there are mild changes, usually of minor significance; in grade 2 moderate changes which need regular observation, and in grade 3 severe changes which indicate impending failure.
(5) The report continues: "We have established that on 9 December, the circle of knowledge of an impending 'big story' by the same Telegraph team who broke [a major political story about British parliamentary expenses] extended to ... a former Telegraph employee now employed by News International ... [who] works closely at News International with the former Telegraph editor Will Lewis , both of whom have strong motivations to damage the Telegraph.
(6) Our results suggest that immediate coronary angioplasty in acute impending myocardial infarction is effective and avoids the need for prior thrombolytic therapy.
(7) This finding suggests that routine measurement of such an electrogram may be a useful tool in predicting impending lead malfunction.
(8) Somatosensory cortical evoked potential studies (SEPs) following stimulation of the pudendal nerves proved useful in objectively documenting preoperative low sacral root involvement in a 33-year-old postlaminectomy patient, presenting with impending cauda equina syndrome and treated by piriformis muscle release with good clinical results.
(9) The goal of this work was to provide clinicians with objective criteria to augment clinical judgment regarding surgical intervention in the impending compartment syndrome.
(10) Of screening tests performed, only LDH was successful in detecting preclinical relapse, with a sensitivity of 42% and specificity of 85% for impending symptomatic relapse.
(11) Gastric bleeding from stress ulcers in acutely sick infants frequently signals impending mortality.
(12) We report the emergence of an erythematous weeping rash with impending exfoliation three years after the initiation of minoxidil therapy.
(13) Six cases of lung cancer combined with the disease which has needed semi-emergency operation, two cases of unstable angina, two of ileus due to colon cancer, one of impending rupture of abdominal aortic aneurysm and one of purulent cholecystitis with cholelithiasis, were discussed.
(14) Napolitano said there was no indication that Abdulmutallab was "part of anything larger" in terms of impending attacks.
(15) A greater use of allylestrenol in the first global evaluation was explained by a higher incidence in these groups of impending miscarriage and preterm labor, which are indications for allylestrenol therapy.
(16) In one example of the import substitution sought by the Kremlin, Russia's president, Vladimir Putin , said at a meeting with representatives of Russia's military-industrial complex on Monday night that the country would replace imported components for its arms production, and the impending "technological difficulties" would in the end be beneficial for the country.
(17) The idea of cutting corporation tax was floated in the Sunday Express last month as a way of wooing banks considering leaving the UK because of an impending Brexit.
(18) We conclude that the rapid LH test was able to predict impending ovulation.
(19) In BBC News, hundreds of jobs are under threat , mostly reporting roles, due to the domestic newsgathering operation's impending merger with the World Service.
(20) To determine criteria for predicting impending first-trimester loss when a normal fetal heart rate is identified sonographically, the authors studied 16 consecutively examined patients with pregnancies of 5.5-9 weeks gestation, a small sac size, and fetuses with normal cardiac activity.