(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Pimped
Definition:
(imp. & p. p.) of Pimp
Example Sentences:
(1) Yves was the vulnerable, suffering artist and Pierre the fiercely controlling protector: a man who, in Lespert's film, is painfully aware of his public image – "the pimp who's found his all-star hooker".
(2) Quite a lot of the downtown action in The Catcher in the Rye (a night out in a fancy hotel; a date with an old girlfriend; an encounter with a prostitute, and a mugging by her pimp) might almost as well describe a young soldier’s nightmare experience of R&R.
(3) Pimps and clients are rarely punished and when prosecutors do manage to build a case against them, survivors often change their testimonies and the cases are thrown out, says Francisco Carlos Pereira de Andrade, a criminal prosecutor who specialises in child exploitation.
(4) Del Seymour knows all about the pimps, drug dealers and vagrants of San Francisco’s Tenderloin district – because he used to be one of them.
(5) A former showgirl from the gravel pits of Wraysbury in Berkshire, Keeler was just 19 and was staying on the estate with her friend, patron and (some said) pimp, the society osteopath Stephen Ward.
(6) Somewhere in here is a story that Refn can hardly be bothered to tell: the psychotic brother of Bangkok-dwelling American Julian (Ryan Gosling) murders a girl, is murdered for it in his turn by the girl's father, who is acting reluctantly under the aegis of a karaoke-loving samurai-cop (Vithaya Pansringarm), an angel of vengeance figure who then subtracts arm number one from the father as punishment for pimping out his late daughter.
(7) The commission looked at abuse and coercion in the industry and found that, contrary to the opinion of Schaffauser and others, criminalising buyers does not lead women to pimps.
(8) Instead of "that prostitute was out all night selling her body", think: "My neighbor (insert name here) was forced by her pimp to stand out in the cold all night and have sex with multiple men she didn't know."
(9) All of life came in – vagrants, prostitutes, pimps, addicts, young people having a laugh, people who'd had too much to drink, police officers finishing shifts, nurses starting shifts, plus the person like my dad who was about to treat his family to a bucket.
(10) The cops arrested him one evening shortly after De Blasio’s speech, on old trespass and marijuana charges, and quizzed him about his relationship with the performers (“Was he their pimp?
(11) While the shop assistants are aware they're playing the role of knicker pimp, of jolly hostess, I wonder if the male customers are aware of their own role, a role learned from the 1970s: flustered man in lingerie department.
(12) Karen wanted to pimp everybody out,” she told the court.
(13) You may think looking at a 17-year-old's Ferrari (" This is how the pimps roll ") might be an exercise in impoverished masochism, but the lack of self-awareness makes the whole experience strangely gratifying.
(14) Pimps, who in some red-light districts will take up to 70% of what a sex worker is paid, were beginning to force women to work for credit, she added.
(15) After Obama's re-election, Nugent said on Twitter: "Pimps whores & welfare brats & their soulless supporters have a president to destroy America."
(16) Kanelli characterised Golden Dawn as an "ideological and political pimp" serving "a mission that the system assigned to it".
(17) In the process he presents unimaginable people – as in Fata Morgana 's (1970) desert characters: the piano-playing madam and drum-playing begoggled pimp playing cabaret music in the Lanzarote brothel; the shellshocked Foreign Legion deserter clinging to a ragged letter from his mother; the lizard-loving German.
(18) A comic called Gerry K tells a joke about watching a pimp fighting with two prostitutes.
(19) You can pimp your kit to match your mobile phone or match your e-liquid to your mood: Golden Virginia flavour for a country pub, mojito for a bender.
(20) Facebook Twitter Pinterest Kendrick Lamar’s Grammy-winning album To Pimp a Butterfly broke down barriers around depression, say experts.