(a.) Born in or with; implanted by nature; innate; as, inborn passions.
Example Sentences:
(1) This is an inborn error of the mitochondrial beta-oxidation of fatty acids.
(2) Fibroblasts cultured from the skin of a patient with metachromatic leukodystrophy have been found to manifest the biochemical defect of this inborn error of metabolism, a deficiency of arylsulfatase A. Diseased cells had less than five per cent of normal arylsulfatase-A activity, while activities of other lysosomal enzymes-including arylsulfatase B, beta-galactosidase, beta-glucuronidase, and beta-N-acetylglucosaminidase-were comparable to those in control cells.
(3) Defects in this enzyme are responsible for one of the most common inborn errors of metabolism in humans.
(4) The current major indications for prenatal diagnosis are Down's syndrome (Trisomy 21), numerous rare inborn errors of metabolism, and neural tube closure defects.
(5) The authors discuss the problem of administration and amount of fluids and electrolytes in neonates after operations of inborn developmental defects and during the postoperative period.
(6) Hurler syndrome, a lethal inborn error of lysosomal metabolism, results from the systemic accumulation of glycosaminoglycan.
(7) Prognosis of this "inborn error of metabolism" is not favorable due to calcium-oxalate depositions in kidney and other organs.
(8) Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a common inborn error of mitochondrial fatty acid oxidation.
(9) The child was also shown to be a genetic carrier for ornithine transcarbamylase deficiency, an x-linked inborn error of urea cycle metabolism.
(10) These patients appear to have deleterious inborn enzymatic abnormalities of a type originally postulated by Garrod.
(11) The surgery also impaired the corrective movements, especially if their direction was opposite to the inborn unconditioned reaction.
(12) It appears that most patients with well recognized disorders are not being diagnosed, and it is our conviction that there are new, as yet unidentified, inborn errors of metabolism in this population of patients.
(13) Inborn and learned ability to detect mild, nonpainful distension of the sygmoid colon was examined in 22 patients who underwent colonostomy one year or more before the investigation.
(14) And so we consider psoriasis to be an inborn fault in the metabolism of epidermal and other cells, which is only provoked by secondary influences (drugs, allergic reactions, local traumas).
(15) The hypothesis is advanced that both phenomena represent inborn dialectical logical instruments of evolution-like human identity creation and maintenance.
(16) Jack Ashley provided the political language and the inborn fighting skill, but she would labour to help him find the killer facts.
(17) We want to modify the albino definition as a hereditary and congenital inborn error of metabolism related to the pigment cell, and resulting in a systemic disorder that is characterized by anomalies of eyes, and hypopigmentation in most cases or absence of pigment in skin, hair, and eyes, and of which the neuro-anatomical consequences are the most characteristic.
(18) In a 5-year period, 476 consecutive live and inborn neonates weighing less than or equal to 1000 gm were studied.
(19) We believe that it is particularly suitable for the rapid and acute diagnosis of inborn errors of metabolism, especially the organic acidurias, and for acute pediatric clinical care, when rapid monitoring of major metabolic alterations is required in a time scale suitable to influence directly and immediately the therapy of the patients concerned.
(20) Serum levels of 7 alpha-hydroxycholesterol, 7 beta-hydroxycholesterol and 26-hydroxycholesterol were determined in several groups of patients: normals, untreated patients suffering from cerebrotendinous xanthomatosis, patients suffering from cerebrotendinous xanthomatosis and treated with either chenodeoxycholic acid or cholic acid in an effective dose, patients suffering from cerebro-hepato-renal syndrome, patients suffering from hypercholesterolemia and treated with cholestyramine for prolonged periods and one patient presumed to be suffering from an inborn error of metabolism in bile acid synthesis.
Inbred
Definition:
(a.) Bred within; innate; as, inbred worth.
(imp. & p. p.) of Inbreed
Example Sentences:
(1) These variants may serve as useful gene markers in alcohol research involving animal model studies with inbred strains in mice.
(2) Groups of inbred female mice of strains CBA or C3H were infected genitally with a pathogenic human strain of Chlamydia trachomatis (N.I.1, serovar F) known to produce salpingitis and infertility in mice.
(3) An N-acetylation polymorphism is described that is expressed toward arylamine carcinogens in tumor target organs of an inbred rat model.
(4) Lymphocytes of inbred mice immunized with allogenic tumour cells were labelled in vitro or in vivo by 3H-thymidine, washed out and incubated with target cells in the presence of "cold" thymidine.
(5) In the present study we screened mice from 22 different inbred strains for potential differences in their immunological reaction to HgCl2.
(6) Using molecular probes to examine somatic cell lines and recombinant inbred and congenic strains of mice, we have re-evaluated these linkage relationships.
(7) We have investigated enhancement of pigmentation in inbred C3H- mice using tail skin as a model for testing the effects of phosphorylated DOPA (DP) and ultraviolet radiation.
(8) These results are discussed in relation to previous reports suggesting a common addiction liability for both morphine and alcohol in inbred strains of animals.
(9) Mta is determined by a maternally transmitted, extrachromosomal genetic element, so backcross mice reject skin from their inbred, homozygous paternal strain.
(10) However, rmm-1, a cis-acting laboratory-induced mutation obtained previously by mutagenesis of inbred strain C3, causes the mutant rmm-1 rDNA to be completely out-replicated by B rDNA.
(11) Inbred strain 2 and random-bred guinea pigs injected oxazolone in incomplete or complete Freund's adjuvant showed contact reactions within an hour after topical application when tested 3 weeks post-sensititization.
(12) 2 inbred brothers with brachydactyly of the index fingers and 1 case of 'achondroplasia' were also found.
(13) An analysis of these recombinant inbred strains may reveal additional mouse genes affecting atherosclerosis susceptibility.
(14) The distribution of derepression among castrated recombinant inbred strains (9 X A) indicated a close link of a locus repressing I-P-450(16 alpha) in male mice to the Rip locus on chromosome 7.
(15) The number of serotonin type 2 receptors (S2) was measured in the frontal cortex of mice belonging to 7 inbred strains using specific 3H-spiperone binding.
(16) This study provides evidence that complement activation by graft-bound alloantibody is a critical effector mechanism of hyperacute rejection in this inbred rat model.
(17) Resistance to MCA-induced lymphoma was dominant over susceptibility in all crosses tested, and in inbred strain mice MCA resistance was found to correlate with resistance to lymphoma induced by a fractionated dose of gamma irradiation.
(18) Earlier studies demonstrated that these inbred birds have normal peripheral blood T and B cell numbers; they also respond normally to allogeneic stimulation.
(19) Estimated genetic progress per generation due to within-line selection was negative in most of the traits in the inbreds but was considerably positive for the linecrosses for most of the traits.
(20) Two types of mitochondrial DNA (mtDNA) can be distinquished in an inbred strain of rats of the Wistar type.