(1) Permeabilized rat hepatocytes were used to study the effects of inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and GTP on Ca2+ uptake and release by ATP-dependent intracellular Ca2+ storage pools.
(2) In this review, we discuss the ligand recognition characteristics of Ins(1,4,5)P3 receptors, and their functional properties in their native environment and after purification, and we relate these properties to what is known of the structure of the receptor.
(3) The growth factor produces an initial, rapid increase in the level of inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) due to hydrolysis of phosphatidyl-inositol-4,5-bisphosphate (Wahl, M., Sweatt, J. D., and Carpenter, G. (1987) Biochem.
(4) Yesterday student occupations were continuing in at least nine universities – including sit-ins in Leeds, Cambridge, Manchester, Edinburgh, University College London, Brighton, Newcastle and the School of African and Oriental Studies in London.
(5) Of the many inositol phosphates recently identified in angiotensin-II-stimulated adrenal glomerulosa and other cells, Ins(1,3,4,5)P4 has been implicated as an additional second messenger that may act in conjunction with Ins(1,4,5)P3 to elicit Ca2+ mobilization.
(6) Among the genes located in 11p15, c-Ha-ras 1 (HRAS1), insulin (INS), and insulin-like growth factor II (IGF2) may account for the clinical features and the increased risk for malignancy.
(7) Cerebellar and adrenal microsomes were used in a ligand-displacement mass assay (conducted under near-physiological conditions, at pH 7.0) on extracts of cerebral-cortex slices stimulated with agonists, and both preparations faithfully detected the increases in Ins(1,3,4,5)P4 that occurred, implying that Ins(1,3,4,5)P4 is the principal ligand on these binding sites in intact cells.
(8) Hence this response differs from the well-characterized Ins(1,4,5)P3 responses of many other systems.
(9) SJ Burnley Ins Michael Keane (Man Utd, £2m) Outs None Sean Dyche’s aim was to retain Danny Ings at all costs and secure more Premier League experience.
(10) I’ve had run-ins with Virgin train lavatories too.
(11) But the outspoken journalist and human rights activist has long been a thorn in Ali Abdullah Saleh's side, agitating for press freedoms and staging weekly sit-ins to demand the release of political prisoners from jail – a place she has been several times herself.
(12) Daily drop-ins and monthly class passes are available.
(13) A subclone containing this inserted DNA (ins 3) hybridizes primarily to rDNA-containing sequences in in situ and genomic blot hybridization experiments.
(14) In blacks, homozygotes for the ins allele had the least involvement of the thoracic and the abdominal aorta with lesions, homozygotes for the del allele had the greatest involvement, and heterozygotes had intermediate involvement (p = 0.0328 for thoracic aorta, p = 0.0104 for abdominal aorta), but no differences were found in whites.
(15) The Ins(1,2,6)P3-K system was ascertained using Sammartano's method which additionally enabled the influence of various K+ concentrations on the protonations constants to be considered.
(16) The same accumulation of Ins(1,3,4,5,6)P5 occurred during neutrophil differentiation, whether it was induced by dimethylsulphoxide or by a combination of retinoic acid and a T-lymphocyte cell line-derived differentiation factor.
(17) This contrasts with the expectation, based on results with cell-free systems, that Ins(1,3,4,6)P4 is synthesized by the direct phosphorylation of Ins(1,3,4)P3.
(18) IgA specific for 7 food and 6 airborne antigens were sought in the serum of 30 adult patients with IgA mesangial nephropathy (IgA GN), 23 with membranous nephropathy (MGN), 20 with idiopathic nephrotic syndrome (INS), 11 with membranoproliferative GN (MPGN) and 22 healthy controls by means of an enzyme-linked immunoassay.
(19) When adipose tissue is incubated first with INS followed by EPI, PDE is activated.
(20) Simultaneously, cellular Ins(1,4,5)P3 contents became markedly elevated, suggesting an AlF4- activation of a phospholipase C-specific G-protein.
Thoroughly
Definition:
(adv.) In a thorough manner; fully; entirely; completely.
Example Sentences:
(1) 2.39pm BST The European Union called for a "thorough and immediate" investigation of the alleged chemical attack.
(2) Before carrier vaccines are applied, these risks must be thoroughly evaluated case-by-case.
(3) To study these changes more thoroughly, specific monoclonal antibodies of the A and B subunits of calcineurin (protein phosphatase 2B) were raised, and regional alterations in the immunoreactivity of calcineurin in the rat hippocampus were investigated after a transient forebrain ischemic insult causing selective and delayed hippocampal CA1 pyramidal cell damage.
(4) A careful history, a thorough physical examination, and an appropriate selection of tests will identify these patients.
(5) Thorough clinical investigation of the patient revealed sarcoid involvement of the skin, lungs, liver and lymph nodes and an extensive retroperitoneal surgically-verified lymph tumour.
(6) Sift the cocoa powder over the top and lightly but thoroughly fold it in with the metal spoon.
(7) A thorough nursing assessment is essential to detect and correct drug misuse and to diagnose drug abuse.
(8) Fetal activity throughout pregnancy has been thoroughly studied.
(9) A high index of suspicion of bilateral tumors and a thorough work-up resulted in the early diagnosis of small tumors.
(10) Results indicate that laryngeal paralysis following severe trauma can be a very early sign of aortic injury and requires prompt and thorough investigation.
(11) A thorough dental prophylaxis before acid-etching of enamel is often recommended.
(12) A thorough family history and an extensive investigation of bleedings in the neonatal period should make early diagnosis possible.
(13) The diagnosis in all patients was made on the base of a thorough clinical examination, the results from the electrocardiography and the selective coronarography.
(14) Xu, the ABP chairman, disputed any claims of impropriety, and said his company went through a “robust and thorough” tender process.
(15) Thorough knowledge of the modes of ventilatory support and criteria for weaning are essential for the critical care nurse to anticipate patient needs.
(16) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(17) It is advisable to examine horses thoroughly during training and to use the results of training for the evaluation of their condition before difficult races.
(18) The requirement for technical reliability of the implantable device for patient safety requires a thorough understanding of all technical and medical details of the therapeutic device.
(19) If LTP is to be effective, thorough coagulation with tender blanching effects is mandatory.
(20) A thorough review of the literature concerning the Frey syndrome is reported.