What's the difference between inoculation and variolation?

Inoculation


Definition:

  • (n.) The act or art of inoculating trees or plants.
  • (n.) The act or practice of communicating a disease to a person in health, by inserting contagious matter in his skin or flesh.
  • (n.) Fig.: The communication of principles, especially false principles, to the mind.

Example Sentences:

  • (1) Whereas strain Ga-1 was practically avirulent for mice, strain KL-1 produced death by 21 days in 50% of the mice inoculated.
  • (2) Charcoal particles coated with the lipid extract were prepared and the suspension inoculated intravenously into mice.
  • (3) The treatment was started either immediately or delayed for 48 h after peritoneal inoculation.
  • (4) Plaque size, appearance, and number were influenced by diluent, incubation temperature after nutrient overlay, centrifugation of inoculated tissue cultures, and number of host cells planted initially in each flask.
  • (5) This suggested that some of the cell population became metabolically inactive at a very early stage, possibly owing to suboptimal conditions of growth.Glycine, lysozyme and lithium chloride initiated lysis of BCG growth in the aforementioned media 24-48 hours after inoculation.
  • (6) A total of 28 cell lines were selected for Geneticin - resistance and inoculated into the footpads of syngeneic animals following co-transfection with pSV2neo and genomic DNA, or transfection with plasmid constructs containing neo and the activated Ha-ras oncogene.
  • (7) None of the animals injected with either CD4+ or CD8+ T cells became overtly diabetic during the 30 days of observation whereas 8 of 23 mice inoculated with a mixture of the two subsets developed glycosuria and hyperglycemia.
  • (8) The hypothesis that experimentally determined survival times of Treponema pallidum in stored donor blood could be related to the number of treponemes initially present in the treponeme-blood mixtures was investigated by inoculating rabbits with three graded doses of treponemes suspended in donor blood and stored at 4 degrees C for various periods of time.
  • (9) Microfilariae were detected fro 2-136 days after inoculation.
  • (10) In contrast, albino rats and rabbits failed to succumb to overt disease by subcutaneous and intraperitoneal routes of inoculation.
  • (11) A large number of recently isolated bacterial pathogens were tested for susceptibility to cephalexin and cephaloglycin by the replica inoculating method.
  • (12) Five control rabbits developed severe diarrhea within 72 h after inoculation with enterotoxigenic E. coli B16-4.
  • (13) Specific antisera prepared in rabbits or in foot-pad-inoculated chickens were adequate for culture typing.
  • (14) It also showed weak inhibition of the solid type of Ehrlich carcinoma and prolonged the survival period of mice inoculated with L-1210 cells.
  • (15) Mice inoculated with tumor cells in the 10 NTX group had an acceleration (18%) in the latency of tumor appearance and, 2 weeks after cell inoculation, 70% of the mice in this group had tumors, in contrast to 10% of the controls.
  • (16) The viruses shed by the volunteers were indistinguishable from those with which they were inoculated.
  • (17) Precipitating antibodies were found in both lines; they first appeared 7 days after inoculation in P-line birds and 14 days after inoculation in N-line birds, but thereafter there was no difference between the two genetic lines.
  • (18) No histological changes in the intestines were observed in the fasted poults whereas definite lesions were observed in the BCDCV-inoculated poults.
  • (19) Cultures of these isolants were inoculated experimentally into turkeys and produced lesions of chlamydiosis that were indistinguishable from those caused by the strain originally recovered from diseases turkeys on the premises.
  • (20) Over a range of concentrations, DMD 368 produced 100% mortality while one Mel 3 strain, DMD 369, produced no mortality by 21 days after inoculation.

Variolation


Definition:

  • (n.) Inoculation with smallpox.

Example Sentences:

  • (1) With smallpox, the variolation (since 1730) gave first relief, until Sir Edward Jenner discovered in 1798 the highly successful cross-immunity through vaccination.
  • (2) Smallpox vaccination was known as variolation before the modern practice of vaccination with cowpox (Vaccinia) was demonstrated in 1796.
  • (3) Man's first attempt to immunize susceptibles against smallpox infection was by variolation, a practice which could be traced back several thousand years.
  • (4) Variolation is an ancient method of protection against naturally acquired smallpox that was officially proscribed in the early 1950s but was renewed in remote areas when smallpox vaccination activities were interrupted during the three-year famine of 1959-1962, following the "great leap forward" program of 1958.
  • (5) The last known cases occurred in 1965, and the practice of variolation is now believed to be extinct.
  • (6) The health authorities responded by capturing the variolators, confiscating their variolation material and equipment, and vaccinating the population.
  • (7) Fear of smallpox provoked the first important attempts to prevent epidemic disease by a primitive form of immunization called variolation.
  • (8) All were among persons who had been variolated or were their close contacts.
  • (9) It is ironic that smallpox became an epidemic pestilence upon the growth of populations, yet it played a major role in preventing population growth until variolation and vaccination became common.
  • (10) It was found that the variolators in Shanxi Province and Nei Monggol Autonomous Region inoculated persons with the use of powdered smallpox scabs mixed with human milk, and that they obtained fresh supplies of scabs every 6-12 months by variolating relatives and friends.
  • (11) Smallpox existed in Romania since the 17th century, when both variolation and vaccinia were used for preventing the disease.
  • (12) Tissot's influence manifested itself also in the early introduction of variolation.

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