(a.) Not operative; not active; producing no effects; as, laws renderd inoperative by neglect; inoperative remedies or processes.
Example Sentences:
(1) Subjects were 56 therapies for HCCs in 48 cases, who were diagnosed as inoperative HCCs, and were performed chemotherapy, transcatheter hepatic arterial embolization (TAE) and percutaneous ethanol injection therapy (PEIT).
(2) Filamentation continued in dif mutants in which SOS-associated division inhibitors were inoperative, which showed that induction of these inhibitors was not the primary cause of filamentation.
(3) If this pressure persisted until the start of the expansion, it would make the opercular suction pump inoperative, because it would blow away the flexible opercular flap which, as a passive valve, seals the widening opercular slit during abduction.
(4) We investigated the incidence and endoscopic features of gastroduodenal lesions which appeared after transcatheter arterial chemo-embolization (TACE), performed 29 times in 25 patients with inoperative hepatocellular carcinoma.
(5) We suggest macrophages may absorb, and thus render inoperative, factors which are necessary for lymphocyte cooperation.
(6) The competitive pattern of this inhibition leads to its being inoperative in ornithine-grown cells, where the intracellular concentration of ornithine is high.
(7) For example, in excised patches of vertebrate rod outer segment plasma membrane, the cGMP-activated cation channels have traditionally been studied in room light because the enzyme cascade linking photon absorption to channel closure was assumed to be inoperative.
(8) Negative feedback of gonadal steroids seems to be inoperative.
(9) Duck erythrocytes treated with norepinephrine in a solution containing 15 mM K+ swell to a new stable cell volume after 60 min, during which time cotransport becomes inoperative.
(10) Such results, obtained from birds in which testosterone feedback was inoperative, indicate that the gonadostimulatory effect of long daylengths in intact males must be mediated, at least in part, by an androgen feedback-independent mechanism.
(11) Induction of recA or polA1 cells by nalidixic acid does not result in the appearance of pol I*, but lexA or recA mutants that are constitutive for SOS functions constitutively express pol I* and mutants which lack functional recA protein produce pol I* when they carry a lexA mutation which renders the lexA repressor inoperative.
(12) Indication of this therapy has been fundamentally limited to the inoperative cases in which patient performance status has deteriorated.
(13) Hence, regulatory mechanisms, inoperative in vitro, probably function in vivo to prevent immune activation of self-recognizing lymphocytes and autoimmunity.
(14) We suggest as an explanation that the majority of daughter strand gap-filling is error free and that mutations arise through a minor error-prone repair pathway which is inoperative under these conditions.
(15) Previous studies demonstrated that hen erythrocytes have an inoperative, latent sphingomyelinase which is activated when the cells are hemolyzed in a hypotonic medium.
(16) It is concluded that the epsilon proofreading subunit of DNA polymerase III holoenzyme is excluded, inhibited, or inoperative during misincorporation and mutagenesis after UV.
(17) One-hundred and eleven species and three species varieties belonging to 39 genera were collected from 50 dust samples on the five media used at 28 degrees C. Using the hair-baiting technique with horse hair, 10 species of Chrysosporium were isolated: C. asperatum, C. state of Arthroderma tuberculatum, C. indicum, C. inops, C. keratinophilum, C. merdarium, C. pannorum, C. queenslandicum, C. tropicum and C. xerophilum.
(18) In such cells the PGK step presumably was inoperative due to total lack of substrate; 2,3-diphosphoglycerate (2,3-DPG) then became the sole substrate source for remaining steps in glycolysis.
(19) This is due to two mutations, one inactivating ATP-driven sodium transport and a second rendering NaH-antiport inoperative.
(20) First, as with the measurements of pulmonary function (Chapter 12), the initial lack of training in adequate maintenance was responsible for inoperative instruments.
Knackered
Definition:
Example Sentences:
(1) Maybe it's left him knackered, but when we talk in the backroom of an ad hoc campaign office in the small agricultural town of Thrapston, he answers most questions using standard-issue candidate's boilerplate.
(2) The boys have just done eight gigs in nine nights and they're knackered.
(3) Prey is a gritty, concretey number, and while Reinhardt may be the least-kempt of the cast, every character drinks too much, looks constantly knackered and is therefore entirely believable.
(4) As Petra, another member of the team, finishes mopping the floors, and Andrew, the shift manager, cashes up the tills in the office downstairs, I slump on to a bar stool, knackered.
(5) The broadcaster described feeling like "a sort of knackered version of myself" after the stroke, which left him with mobility issues down his left side.
(6) "And watching the match, Pirlo and most of the Italians looked knackered, even misplacing easy short passes to unmarked colleagues, and either not making runs or making runs that were lazy and easy to catch off-side.
(7) Respected animal welfare organisations have warned governments for several years about the growing trade in knackered horses both between Ireland, the UK, France and Belgium, and between North and South America, and continental Europe.
(8) 71 min: Dean Windass, who looks knackered, is replaced by Caleb Folan.
(9) I lean on Suárez’s shoulder and tell him I’m knackered.
(10) But one staff member said: "It was like a car that looked good from the outside but it was knackered."
(11) ET 1 min: Both teams look knackered, with the exception of Gattuso on the Milan team, who looks like a Tazmanian devil on amphetamines.
(12) It's set in and around Kansas City 2044, but the future looks, frankly, knackered.
(13) 9.26pm GMT Arsenal substitution: Flamini on for Oxlade-Chamberlain, who looks knackered.
(14) It's feeling physically knackered, such as in the knees from years of standing up day after day.
(15) Real Madrid 3-1 Atlético Madrid (Marcelo ET 28) Atlético are knackered.
(16) "I arrived here just knackered, thinking I don't really want to do this," admits Coogan.
(17) He agreed, saying sitting back and absorbing constant attacks knackers you.
(18) Ministers were knackered and most had already disengaged from their jobs.
(19) Perhaps this is the person she truly wants to be – an ordinary mum, bit knackered, only able to get out of the house because her own mum's doing the babysitting – and was just unlucky to fall in love with Prince William rather than the local butcher.
(20) After all, being sleep deprived makes you miserable, knackered and liable to crash the car.