(a.) Not sensitive; wanting sensation, or wanting acute sensibility.
Example Sentences:
(1) In contrast, DNA polymerase alpha, the enzyme involved in chromosomal DNA replication, was relatively insensitive to CA1.
(2) However, CT will be insensitive in the detection of the more cephalic proximal lesions, especially those in the brain stem, basal cisterns, and skull base.
(3) Insensitive variants die more slowly than wild type cells, with 10-20% cell death observed within 24 h after addition of dexamethasone.
(4) The mechanism by which K+ accumulates in the follicle was insensitive to ouabain, so that a typical Na+, K(+)-ATPase mechanism does not appear to be involved.
(5) All three organotins inhibited cardiac Na+,K(+)-ATPase, [3H]ouabain binding, K(+)-activated p-nitrophenyl phosphatase (K(+)-PNPPase) and oligomycin-sensitive (OS) and oligomycin-insensitive (OI) Mg(2+)-ATPase in a concentration-dependent manner.
(6) The most important causal factor, well illustrated by pressure studies, was the presence of a dynamic or static deformity leading to local areas of peak pressure on insensitive skin.
(7) However, blood with low HBeAg levels and free of detectable polymerase activity can still be infectious, since the polymerase reaction is rather insensitive compared to the radioimmunological HBeAg determination.
(8) For those synapses that were close to the soma the time constant for decay for the non-NMDA component, which was voltage insensitive, ranged from 4-8 ms. 7.
(9) A sharp decrease in oxygen uptake occurred in Neurospora crassa cells that were transferred from 30 degrees C to 45 degrees C, and the respiration that resumed later at 45 degrees C was cyanide-insensitive.
(10) The response amplitude is maximally sensitive to photons presented over durations of 30-45 min; is very insensitive to shorter light exposures; and is maintained with no evidence of adaptation over longer exposures.
(11) In contrast to the channel closing rate, the opening rate is relatively insensitive to voltage.
(12) By using pH- or Ca(2+)-sensitive dyes and recording at the ion-sensitive and -insensitive (isosbestic) wavelengths, the method can measure both cell volume changes and intracellular ionic activities.
(13) In patients with Cushing's disease or Nelson's syndrome ACTH secretion is insensitive to naloxone, presumably because of an autonomous pituitary adenoma or hypothalamic derangement.
(14) Compared to the controls, the vitamin E deprived animals were relatively insensitive to the effects of scopolamine.
(15) The chemical shifts of the C-2 proton of histidine 48 and of the C-4 proton of histidine 80, histidine residues that are close to one another and to another heterosaccharide side chain, show a similar insensitivity.
(16) Activity was insensitive to oxygen and CO if the substrates had no additional substituents on either ring or contained only electron-donating substituents.
(17) In some cases (approximately equal to 10%) the mechanism of androgen insensitivity could not be identified.
(18) We found the incorporated channels to be insensitive to calcium and octanol, and in most cases to pH in the range of 5-7, suggesting that either these agents do not interact directly with the junctional channels or that the corresponding gating regions are inactivated during the isolation and reconstitution procedures.
(19) The cattle filarial parasite Setaria digitata, a facultative anaerobe which is reported to be cyanide insensitive, lacks cytochromes and presents many unique characters.
(20) V0 estimates derived from the low load portion were positive and relatively insensitive to Ees.
Insult
Definition:
(v. t.) The act of leaping on; onset; attack.
(v. t.) Gross abuse offered to another, either by word or act; an act or speech of insolence or contempt; an affront; an indignity.
(v. t.) To leap or trample upon; to make a sudden onset upon.
(v. t.) To treat with abuse, insolence, indignity, or contempt, by word or action; to abuse; as, to call a man a coward or a liar, or to sneer at him, is to insult him.
(v. i.) To leap or jump.
(v. i.) To behave with insolence; to exult.
Example Sentences:
(1) The variation of the activity of the peptidase with pH in the presence of various inhibitors was investigated in both control and insulted muscle fibres.
(2) To study these changes more thoroughly, specific monoclonal antibodies of the A and B subunits of calcineurin (protein phosphatase 2B) were raised, and regional alterations in the immunoreactivity of calcineurin in the rat hippocampus were investigated after a transient forebrain ischemic insult causing selective and delayed hippocampal CA1 pyramidal cell damage.
(3) Histopathological studies confirmed that mice fed 933cu-rev died from bilateral renal cortical tubular necrosis consistent with toxic insult, perhaps due to Shiga-like toxins.
(4) Combined with histological analysis, these results suggest a more rapid recovery of normal spermatogenesis after physical insult with LAC treatment.
(5) Mark Latham's insights, insults and feuds are why he's worth reading | Gay Alcorn Read more BuzzFeed political editor Mark Di Stefano, the reporter who broke the story linking Latham to the less-than-savoury @RealMarkLatham Twitter account , had been chasing Stutchbury for days.
(6) Among the various physiological factors involved in the development of a nephrotoxic insult, certain renal transport systems may be important.
(7) In addition, PROM is the result of direct bacterial insults or host-mediated autodestruction in response to bacterial presence or challenge.
(8) Postmortem biochemical indices may provide a useful adjunct to morphological studies in the identification of antemortem brain insult.
(9) This toxic effect, although not seen in intact nigrostriatal systems, may indicate L-dopa toxicity on transplanted DA cells, or on DA cells maximally activated to recover from insult.
(10) Under the conditions employed in these studies, repeated occlusions give rise to progressively more prolonged deficits in brain protein synthesis activity, which may thus provide a useful index of the severity of the accumulated ischemic insult.
(11) The loss of coronary reserve was less than that previously observed after a 15-min occlusion, suggesting that the magnitude of the postischemic vascular abnormalities increases with the duration of the ischemic insult.
(12) We also observed a difference in the pattern and severity of alterations between repeated ischemic insults and single ischemia.
(13) Unconsciousness was associated with a brief period of hypotension, so brief that in itself it caused no apparent insult.
(14) These findings suggest that NB-818 may be useful for clinical treatment of neurological deficit after an ischemic insult.
(15) For example, patients suffering from transfusion-related acute lung injury (TRALI) experience onset of insult within 6 hours of a transfusion and have the presence of leukoagglutinins in their serum.
(16) This review article discusses the clinical manifestations and the diagnostic workup of insults to the kidney in patients with cancer.
(17) We have recently demonstrated in vitro a potential biological mechanism which could occur in vivo upon inhaling airborne graon dust, thereby constituting a potential inflammatory insult to the respiratory tracts of grain workers.
(18) It is hypothesized that transmission failure of interneuronal systems in the initial period following insult may be a general response occurring in wide areas of the central nervous system, and not restricted to areas to which mechanical stress is directly applied.
(19) These shape changes may become irreversible and, in fact, they may be encountered in different types of haemolytic disease, suggesting that the echinocytic and stomatocytic shape changes represent two fundamental ways in which red cells react to intrinsic and extrinsic insults.
(20) The Labour party erupted into open civil war as Ed Miliband loyalists and supporters of Johann Lamont, the Scottish Labour leader who resigned this weekend, exchanged accusations and insults.