(a.) Not sensitive; wanting sensation, or wanting acute sensibility.
Example Sentences:
(1) In contrast, DNA polymerase alpha, the enzyme involved in chromosomal DNA replication, was relatively insensitive to CA1.
(2) However, CT will be insensitive in the detection of the more cephalic proximal lesions, especially those in the brain stem, basal cisterns, and skull base.
(3) Insensitive variants die more slowly than wild type cells, with 10-20% cell death observed within 24 h after addition of dexamethasone.
(4) The mechanism by which K+ accumulates in the follicle was insensitive to ouabain, so that a typical Na+, K(+)-ATPase mechanism does not appear to be involved.
(5) All three organotins inhibited cardiac Na+,K(+)-ATPase, [3H]ouabain binding, K(+)-activated p-nitrophenyl phosphatase (K(+)-PNPPase) and oligomycin-sensitive (OS) and oligomycin-insensitive (OI) Mg(2+)-ATPase in a concentration-dependent manner.
(6) The most important causal factor, well illustrated by pressure studies, was the presence of a dynamic or static deformity leading to local areas of peak pressure on insensitive skin.
(7) However, blood with low HBeAg levels and free of detectable polymerase activity can still be infectious, since the polymerase reaction is rather insensitive compared to the radioimmunological HBeAg determination.
(8) For those synapses that were close to the soma the time constant for decay for the non-NMDA component, which was voltage insensitive, ranged from 4-8 ms. 7.
(9) A sharp decrease in oxygen uptake occurred in Neurospora crassa cells that were transferred from 30 degrees C to 45 degrees C, and the respiration that resumed later at 45 degrees C was cyanide-insensitive.
(10) The response amplitude is maximally sensitive to photons presented over durations of 30-45 min; is very insensitive to shorter light exposures; and is maintained with no evidence of adaptation over longer exposures.
(11) In contrast to the channel closing rate, the opening rate is relatively insensitive to voltage.
(12) By using pH- or Ca(2+)-sensitive dyes and recording at the ion-sensitive and -insensitive (isosbestic) wavelengths, the method can measure both cell volume changes and intracellular ionic activities.
(13) In patients with Cushing's disease or Nelson's syndrome ACTH secretion is insensitive to naloxone, presumably because of an autonomous pituitary adenoma or hypothalamic derangement.
(14) Compared to the controls, the vitamin E deprived animals were relatively insensitive to the effects of scopolamine.
(15) The chemical shifts of the C-2 proton of histidine 48 and of the C-4 proton of histidine 80, histidine residues that are close to one another and to another heterosaccharide side chain, show a similar insensitivity.
(16) Activity was insensitive to oxygen and CO if the substrates had no additional substituents on either ring or contained only electron-donating substituents.
(17) In some cases (approximately equal to 10%) the mechanism of androgen insensitivity could not be identified.
(18) We found the incorporated channels to be insensitive to calcium and octanol, and in most cases to pH in the range of 5-7, suggesting that either these agents do not interact directly with the junctional channels or that the corresponding gating regions are inactivated during the isolation and reconstitution procedures.
(19) The cattle filarial parasite Setaria digitata, a facultative anaerobe which is reported to be cyanide insensitive, lacks cytochromes and presents many unique characters.
(20) V0 estimates derived from the low load portion were positive and relatively insensitive to Ees.
Numb
Definition:
(a.) Enfeebled in, or destitute of, the power of sensation and motion; rendered torpid; benumbed; insensible; as, the fingers or limbs are numb with cold.
(a.) Producing numbness; benumbing; as, the numb, cold night.
(v. t.) To make numb; to deprive of the power of sensation or motion; to render senseless or inert; to deaden; to benumb; to stupefy.
Example Sentences:
(1) Symptoms include numbness, tingling and pain in the anterolateral thigh.
(2) Headache and vertigo were not linked with exposure to vibration in forestry and a significant part of the numbness reported may be due to the carpal tunnel syndrome.
(3) With grievous amazement, never self-pitying but sometimes bordering on a sort of numbed wonderment, Levi records the day-to-day personal and social history of the camp, noting not only the fine gradations of his own descent, but the capacity of some prisoners to cut a deal and strike a bargain, while others, destined by their age or character for the gas ovens, follow "the slope down to the bottom, like streams that run down to the sea".
(4) Forty-four patients of meralgia paraesthetica presented with combination of symptoms mainly of numbness with loss of superficial sensation on the anterolateral aspect of a thigh were selected for the study.
(5) Postoperatively, the weakness of the lower extremities was improved immediately, but numbness remained.
(6) Numbness sets in.” Philip Hope-Wallace on Look Back in Anger “I must be the only playwright this century to have been pursued up a London street by an angry mob … There was an inescapable tension in the house.
(7) A case is reported of a patient with sudden onset, generalized toothache accompanied with a numb chin and lower lip.
(8) A 57-year-old man was admitted with the complaints of vague headache and left upper limb numbness.
(9) Unilateral enlargement of the tibialis anterior muscle associated with complex repetitive discharges occurred over several months in two patients and was preceded by pain and numbness in the lower leg.
(10) But after 14 hours Danilkin's numbing monologue – almost a carbon copy of the prosecutors's case – is beginning to pall.
(11) In the nineteenth century, some natives of Peru noticed circumoral numbness, euphoria and analgesia after chewing the leaves of the Erythroxylen coca bush.
(12) In a random sample of 3000 women of ages eighteen to fifty-nine years in the city of Västerås, Sweden, 19% of the 2705 responders to a questionnaire complained of cold and white fingers with or without numbness.
(13) There were some hormonal patterns characteristic of individual complaints; hot flush was associated with increased FSH and LH, and decreased E1 and E2; difficulty in falling asleep, excitability, and fatigability, with increased FSH and LH, and decreased E2; nervousness, with increased LH and decreased E2; headache, with increased LH and PRL, and decreased E2; feeling of cold, with decreased E2 and PRL; and numbness and shoulder stiffness, with decreased E2.
(14) Other common manifestations were unilateral leg pain, numbness or weakness of the leg, and evidence of mild cauda equina compression.
(15) Major symptoms included progressive hearing loss, facial numbness, occipital headaches, dizziness, and diplopia of less than a year's duration.
(16) A case is reported in which mandibular swelling and lower lip numbness were the first signs of a metastatic adenocarcinoma of the lung.
(17) A 60 year-old man complained of numbness and pain in the right lower limb, suggesting lesions of the fifth lumbar and first sacral roots.
(18) The prevalence of VWF, numbness and coldness of the fingers, and coldness of the legs was higher the longer the total chain saw operating period.
(19) 3) At the severe stage, pain and dullness at the back, numbness at arms and hands, hand coldness, sleep disturbance etc.
(20) The perioral numbness (paresthesia) experienced at doses of 750, 900, and 1,000 mg was probably drug related.