(a.) Not sensitive; wanting sensation, or wanting acute sensibility.
Example Sentences:
(1) In contrast, DNA polymerase alpha, the enzyme involved in chromosomal DNA replication, was relatively insensitive to CA1.
(2) However, CT will be insensitive in the detection of the more cephalic proximal lesions, especially those in the brain stem, basal cisterns, and skull base.
(3) Insensitive variants die more slowly than wild type cells, with 10-20% cell death observed within 24 h after addition of dexamethasone.
(4) The mechanism by which K+ accumulates in the follicle was insensitive to ouabain, so that a typical Na+, K(+)-ATPase mechanism does not appear to be involved.
(5) All three organotins inhibited cardiac Na+,K(+)-ATPase, [3H]ouabain binding, K(+)-activated p-nitrophenyl phosphatase (K(+)-PNPPase) and oligomycin-sensitive (OS) and oligomycin-insensitive (OI) Mg(2+)-ATPase in a concentration-dependent manner.
(6) The most important causal factor, well illustrated by pressure studies, was the presence of a dynamic or static deformity leading to local areas of peak pressure on insensitive skin.
(7) However, blood with low HBeAg levels and free of detectable polymerase activity can still be infectious, since the polymerase reaction is rather insensitive compared to the radioimmunological HBeAg determination.
(8) For those synapses that were close to the soma the time constant for decay for the non-NMDA component, which was voltage insensitive, ranged from 4-8 ms. 7.
(9) A sharp decrease in oxygen uptake occurred in Neurospora crassa cells that were transferred from 30 degrees C to 45 degrees C, and the respiration that resumed later at 45 degrees C was cyanide-insensitive.
(10) The response amplitude is maximally sensitive to photons presented over durations of 30-45 min; is very insensitive to shorter light exposures; and is maintained with no evidence of adaptation over longer exposures.
(11) In contrast to the channel closing rate, the opening rate is relatively insensitive to voltage.
(12) By using pH- or Ca(2+)-sensitive dyes and recording at the ion-sensitive and -insensitive (isosbestic) wavelengths, the method can measure both cell volume changes and intracellular ionic activities.
(13) In patients with Cushing's disease or Nelson's syndrome ACTH secretion is insensitive to naloxone, presumably because of an autonomous pituitary adenoma or hypothalamic derangement.
(14) Compared to the controls, the vitamin E deprived animals were relatively insensitive to the effects of scopolamine.
(15) The chemical shifts of the C-2 proton of histidine 48 and of the C-4 proton of histidine 80, histidine residues that are close to one another and to another heterosaccharide side chain, show a similar insensitivity.
(16) Activity was insensitive to oxygen and CO if the substrates had no additional substituents on either ring or contained only electron-donating substituents.
(17) In some cases (approximately equal to 10%) the mechanism of androgen insensitivity could not be identified.
(18) We found the incorporated channels to be insensitive to calcium and octanol, and in most cases to pH in the range of 5-7, suggesting that either these agents do not interact directly with the junctional channels or that the corresponding gating regions are inactivated during the isolation and reconstitution procedures.
(19) The cattle filarial parasite Setaria digitata, a facultative anaerobe which is reported to be cyanide insensitive, lacks cytochromes and presents many unique characters.
(20) V0 estimates derived from the low load portion were positive and relatively insensitive to Ees.
Tactless
Definition:
(a.) Destitute of tact.
Example Sentences:
(1) "I haven't done years of diversity training, so sometimes I say things which are probably tactless, and I don't mean to, to be honest, I don't mean to do that.
(2) There was one sticky moment, when Mr Cameron was reminded by a tactless journalist that he had once described his new coalition partner as "my favourite political joke".
(3) Jean-Paul Corap, an artist, felt the tweet was tactless.
(4) Little wonder that tactless buyers at Asda rubber-stamped the rapidly withdrawn "Mental Patient" fancy dress costume when "mental" is routinely worn as a badge of gregarious honour.
(5) the physician-originated spread of "shipyard eye," tactless behavior toward patients, and lapses in malaria eradication programs.
(6) Little, Will Mellor, Natalie Casey and Sheridan Smith may be the bigger names, but Louise is the comic genius - needy, self-obsessed and tactless to the point of psychopathology.
(7) All kinds of petty discomforts – overcrowded rooms, long hours, arbitrary or tactless treatment – were overlooked in the general sense of adventure, progress, and public service.
(8) I ask if she still listens to the show, and get the most comically tactless answer: “No, I don’t.
(9) Last year he managed to stir up a massive row over a long-dead economist when he suggested that John Maynard Keynes had no stake in the future because he was gay and childless – although he did later apologise, calling his remarks "stupid and tactless".
(10) A tactless candidate was another problem: Maria Hutchings came across as more Ukip and less Conservative than Ukip's own smooth-talking Diane James.
(11) It is true that there has been some tactless western patronising along the way.
(12) Though foreign media highlighted Berlusconi's characteristically tactless remark that the homeless should think of themselves as being on a "camping weekend", his slip was barely reported in Italy itself.
(13) In 2003, he headbutted a policeman in a Paris casino rumpus and was subsequently fined and given a suspended jail term, tactlessly telling the press that to assault a cop was “the dream of every Frenchman”.
(14) The rant about late payments was many things: unprofessional, relentless, vitriolic when he dealt with listeners telling him to stop moaning, self-indulgent, and tactless with a young audience who will be feeling the effects of the recession more acutely than many other radio audiences.
(15) David Cameron's team, alas, seem to specialise in snoozing, sloppy pizza and total tactlessness – and nothing will ever be properly regulated that way.
(16) I fell asleep in front of Mamma Mia!, a show the teenage me found entirely baffling and geared towards, as I explained tactlessly to my mother, "women of a certain age".