(a.) Containing, or characterized by, insult or abuse; tending to insult or affront; as, insulting language, treatment, etc.
Example Sentences:
(1) The variation of the activity of the peptidase with pH in the presence of various inhibitors was investigated in both control and insulted muscle fibres.
(2) To study these changes more thoroughly, specific monoclonal antibodies of the A and B subunits of calcineurin (protein phosphatase 2B) were raised, and regional alterations in the immunoreactivity of calcineurin in the rat hippocampus were investigated after a transient forebrain ischemic insult causing selective and delayed hippocampal CA1 pyramidal cell damage.
(3) Histopathological studies confirmed that mice fed 933cu-rev died from bilateral renal cortical tubular necrosis consistent with toxic insult, perhaps due to Shiga-like toxins.
(4) Combined with histological analysis, these results suggest a more rapid recovery of normal spermatogenesis after physical insult with LAC treatment.
(5) Mark Latham's insights, insults and feuds are why he's worth reading | Gay Alcorn Read more BuzzFeed political editor Mark Di Stefano, the reporter who broke the story linking Latham to the less-than-savoury @RealMarkLatham Twitter account , had been chasing Stutchbury for days.
(6) Among the various physiological factors involved in the development of a nephrotoxic insult, certain renal transport systems may be important.
(7) In addition, PROM is the result of direct bacterial insults or host-mediated autodestruction in response to bacterial presence or challenge.
(8) Postmortem biochemical indices may provide a useful adjunct to morphological studies in the identification of antemortem brain insult.
(9) This toxic effect, although not seen in intact nigrostriatal systems, may indicate L-dopa toxicity on transplanted DA cells, or on DA cells maximally activated to recover from insult.
(10) Under the conditions employed in these studies, repeated occlusions give rise to progressively more prolonged deficits in brain protein synthesis activity, which may thus provide a useful index of the severity of the accumulated ischemic insult.
(11) The loss of coronary reserve was less than that previously observed after a 15-min occlusion, suggesting that the magnitude of the postischemic vascular abnormalities increases with the duration of the ischemic insult.
(12) We also observed a difference in the pattern and severity of alterations between repeated ischemic insults and single ischemia.
(13) Unconsciousness was associated with a brief period of hypotension, so brief that in itself it caused no apparent insult.
(14) These findings suggest that NB-818 may be useful for clinical treatment of neurological deficit after an ischemic insult.
(15) For example, patients suffering from transfusion-related acute lung injury (TRALI) experience onset of insult within 6 hours of a transfusion and have the presence of leukoagglutinins in their serum.
(16) This review article discusses the clinical manifestations and the diagnostic workup of insults to the kidney in patients with cancer.
(17) We have recently demonstrated in vitro a potential biological mechanism which could occur in vivo upon inhaling airborne graon dust, thereby constituting a potential inflammatory insult to the respiratory tracts of grain workers.
(18) It is hypothesized that transmission failure of interneuronal systems in the initial period following insult may be a general response occurring in wide areas of the central nervous system, and not restricted to areas to which mechanical stress is directly applied.
(19) These shape changes may become irreversible and, in fact, they may be encountered in different types of haemolytic disease, suggesting that the echinocytic and stomatocytic shape changes represent two fundamental ways in which red cells react to intrinsic and extrinsic insults.
(20) The Labour party erupted into open civil war as Ed Miliband loyalists and supporters of Johann Lamont, the Scottish Labour leader who resigned this weekend, exchanged accusations and insults.
Intolerable
Definition:
(a.) Not tolerable; not capable of being borne or endured; not proper or right to be allowed; insufferable; insupportable; unbearable; as, intolerable pain; intolerable heat or cold; an intolerable burden.
(a.) Enormous.
Example Sentences:
(1) To investigate the relationship between Helicobacter pylori infection and nonsteroidal anti-inflammatory drug (NSAID) intolerance and the effect of gold use on the seroprevalence of H. pylori.
(2) Several pedigrees have been reported in which defects of the insulin gene result in glucose intolerance or diabetes in affected members, but the role of insulin gene mutations in NIDDM is unknown.
(3) Total white cell counts were reviewed in paediatric in-patients with viral gastroenteritis, bacterial gastroenteritis, delayed recovery following acute gastroenteritis, viral lower respiratory tract infections and cow's milk protein intolerance.
(4) Stress may increase to an intolerable level with the number of tasks, with higher qualified work and due to the lack of familiarity with fellow workers in ever changing settings.
(5) In the remaining 39% the most common causes were represented by intolerance reactions (16%), infection causes (16%) and physical causes (13%).
(6) Thirteen asthmatic subjects (six aspirin tolerant and seven aspirin intolerant) in a stable clinical condition and ten healthy subjects were studied.
(7) In some of the 10 patients who tolerated cow's milk challenge clinically there was an increase in both IgA- and IgM-containing cells suggestive of a local immunological reaction although no clinical intolerance was provoked and other immunological signs were weak or absent.
(8) Obesity is characterized by a high risk for glucose intolerance and cardiovascular disease.
(9) To determine the pathogenesis of carbohydrate intolerance associated with gonadal dysgenesis, plasma glucose, insulin, glucagon, and growth hormone responses to oral glucose and intravenous tolbutamide, arginine and insulin were evaluated in 21 nonobese patients, 7-19 years old.
(10) Pregnancy, hyperthyroidism and intolerances are given as contraindications.
(11) Reasons for stopping treatment early included progressive disease, stable disease without symptomatic improvement, or severe toxicity deemed intolerable by either the patient or physician.
(12) An obsessional artist who was an enemy of all institutions, cinematic as well as social, and whose principal theme was intolerance, he invariably gets delivered to us today by institutions - most recently the National Film Theatre, which starts a Dreyer retrospective this month - that can't always be counted on to represent him in all his complexity.
(13) Most patients with abnormal OGTT's fell into the latter group, but some had glucose intolerance without either an exaggerated insulin response or insulin resistance.
(14) Commonly associated medical problems include hypertension in 50%, hyperlipidemia in 41%, and diabetes mellitus or glucose intolerance in 14%.
(15) Eleven infants recovering from protein-calorie malnutrition secondary to acquired monosaccharide intolerance were found to have reduced plasma bicarbonate concentration associated with inadequate weight gain.
(16) These include disease activity, presence or absence of symptoms, degree of deformity and resultant potential for complications, shoe intolerance, and level of activity.
(17) Our ability to design effective countermeasures to orthostatic circulatory intolerance is severely handicapped by our inadequate knowledge of the basic hemodynamic events incident to normal and abnormal orthostatic tolerance.
(18) Cow's milk protein intolerance (CMPI) is recognised as an important cause of protean symptoms in infants.
(19) Successful use of PMP in one steroid and cytotoxic drug intolerant patient with AIED led to its use in a total of eight patients.
(20) Extracardiac adverse effects of quinidine include potentially intolerable gastrointestinal effects and hypersensitivity reactions such as fever, rash, blood dyscrasias and hepatitis.