(v. t.) To link together; to unite closely or firmly, as by a chain.
Example Sentences:
(1) Brief digestion at neutral pH without reduction produced a molecule in which the Fab and Fc fragments were still linked by a pair of labile disulphide bridges, and the Fc fragment released by cleaving these bonds, called 1Fc fragment, contained a portion of the ;hinge' region including an interchain disulphide bridge.
(2) It is suggested that a general manner of folding may be a common feature of the heterogeneous population of kappa-chains: one bridge which folds an invariable stretch of the chain, another bridge which folds a stretch that varies from protein to protein, and a bridge at the C-terminus which is the interchain link.
(3) A6.1 reacts with the 70-kDa fragment generated by chymotrypsin in EDTA which contains the interchain disulfide bonds of TSP and the binding site(s) for type V collagen (Mumby, S. M., Raugi, G. J., and Bornstein, P. (1984) J.
(4) This fragment consists of the VH-domain and the N-terminal residues of the C mu 1 domain preceding the interchain half-cystine.
(5) It is suggested that distortion in the hexagonal lattice below the pretransition temperature previously reported by X-ray diffraction techniques may be responsible for interchain interactions which give rise to a Raman band observed only in the triclinic lattice of even-numbered n-alkanes.
(6) The dimer is stabilized by the ninth cysteine, which forms an interchain disulfide bond, and by two identical hydrophobic interfaces.
(7) In the fluid state, a deeper penetration into the lipid matrix is proposed based on the downshift of the phase transition and the low vibrational interchain coupling.
(8) The conformation of the interchain disulfide bond between the light and the heavy chains of human immunoglobulin G4 (IgG4) was modeled based on the known structure of a human IgG1 Fab.
(9) However, when the interchain disulfide bonds of antibodies were reduced and alkylated, the removal of the lambda-anti-lambda, HSA-anti-HSA, and gammaG-anti-gammaG complexes was altered.
(10) To delineate the role of the heparin-binding domain in matrix assembly and to define further the precise region of interchain disulphide bonding that results in trimer formation, we have expressed deleted forms of the cDNA encoding TSP in SV-40-transformed.
(11) In nonreducing conditions, gp55P is a unique disulfide-bonded dimer, whereas RER gp55 consists of monomers and dimers with diverse intrachain and interchain disulfide bonds.
(12) These irreversible changes may be interpreted as a consequence of formation of interchain contacts (non-covalent "cross-links").
(13) Interchain distances and orientations are suitable for cystine cross-linking.
(14) A major cell binding site was found in the trimeric cyanogen bromide-derived fragment CB3, located 100 nm away from the NH2 terminus of the molecule, in which the triple-helical conformation is stabilized by interchain disulfide bridges.
(15) Oligosaccharide I contains two alpha-D-galactopyranosyl residues and one D-glucitol residue and thus constitutes the branch point in the group B antigen, whereas II contains one of each of the above residues and therefore is situated in linear interchain positions.
(16) The major component (about 85%) is a branched beta-(1-->3)-glucan of high molecular weight (about 240000) containing 3% of beta-(1-->6)-glucosidic interchain linkages.
(17) Boar sperm acrosin contains twelve cysteine residues forming two interchain and 4 intrachain disulfide bonds.
(18) These results indicated site-specific cross-linking of interchain sulfhydryls and places their distance within 3-4 A.
(19) Substitution of the cysteine at position 580 by alanine resulted in impairment of interchain disulfide bridge formation; the mutagenized enzyme (C580A) was secreted from recombinant cells in the monomeric form and failed to assemble into dimers.
(20) Sodium dodecyl sulphate-polyacrylamide gel electrophoresis under reducing and non-reducing conditions indicated that purified monomers of this VASP are linked by interchain disulphide bonding.
Link
Definition:
(n.) A torch made of tow and pitch, or the like.
(n.) A single ring or division of a chain.
(n.) Hence: Anything, whether material or not, which binds together, or connects, separate things; a part of a connected series; a tie; a bond.
(n.) Anything doubled and closed like a link; as, a link of horsehair.
(n.) Any one of the several elementary pieces of a mechanism, as the fixed frame, or a rod, wheel, mass of confined liquid, etc., by which relative motion of other parts is produced and constrained.
(n.) Any intermediate rod or piece for transmitting force or motion, especially a short connecting rod with a bearing at each end; specifically (Steam Engine), the slotted bar, or connecting piece, to the opposite ends of which the eccentric rods are jointed, and by means of which the movement of the valve is varied, in a link motion.
(n.) The length of one joint of Gunter's chain, being the hundredth part of it, or 7.92 inches, the chain being 66 feet in length. Cf. Chain, n., 4.
(n.) A bond of affinity, or a unit of valence between atoms; -- applied to a unit of chemical force or attraction.
(n.) Sausages; -- because linked together.
(v. t.) To connect or unite with a link or as with a link; to join; to attach; to unite; to couple.
(v. i.) To be connected.
Example Sentences:
(1) However, when cross-linked to anti-CD4 or anti-CD8 antibodies a markedly enhanced proliferation of the corresponding subpopulation is observed.
(2) Each process has been linked to the regulation of cholesterol accretion in the arterial cell.
(3) The quaternary structure of ribonucleotide reductase of Escherichia coli was investigated, with the use of purified B1 and B2 proteins and bifunctional cross-linking agents.
(4) The mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis is anomalous since the undenatured, cross-linked proteins have the same Stokes radius as the native, uncross-linked alpha beta gamma heterotrimer.
(5) 10D1 mAb induced a substantial proliferation of peripheral blood T cells when cross-linked with goat anti-mouse Ig antibody.
(6) Mapping of the cross-link position between U2 and U6 RNAs is consistent with base-pairing between the 5' domain of U2 and the 3' end of U6 RNA.
(7) We have measured the antibody specificities to the two polysaccharides in sera from asymptomatic group C meningococcal carriers and vaccinated adults by a new enzyme-linked immunosorbent assay (ELISA) procedure using methylated human serum albumin for coating the group C polysaccharide onto microtiter plates.
(8) For the detection of this antigen, a double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was employed.
(9) The haplotype of the recombinant X chromosome of each of 241 backcross progeny has been established using the X-linked anchor loci Otc, Hprt, Dmd, Pgk-1, and Amg and the additional probes DXSmh43 and Cbx-rs1.
(10) Bipolar derivations with the maximum PSE always included the locations with the maximum PSE obtained from a linked ears reference.
(11) The antibody was covalently linked to polyacrylamide microbeads with no change in binding characteristics.
(12) A one point dilution enzyme-linked immunosorbent assay (ELISA) procedure suitable for determining immunoglobulin G (IgG) antibody levels to Toxoplasma gondii (T. gondii) in community seroepidemiological surveys is described.
(13) A Swedish news agency said it had received an email warning before the blasts in which a threat was made against Sweden's population, linked to the country's military presence in Afghanistan and the five-year-old case of caricatures of the prophet Muhammad by Swedish artist Lars Vilks.
(14) It is possible that the IgE that linked abnormally with the propofol had specific binding sites for the phenyl nucleus and the isopropyl groups, which are present in propofol and many other drugs.
(15) Peptide:N-glycosidase F removed both the asparagine-linked oligosaccharide chains of ricin B-chain in the absence of lactose.
(16) Mechanisms by which a defect in the synthesis of dolichol-oligosaccharides might alter the degree of beta-1,6 branching in N-linked carbohydrates are discussed.
(17) Men who ever farmed were at slightly elevated risk of non-Hodgkin's lymphoma (odds ratio = 1.2, 95% confidence interval = 1.0-1.5) that was not linked to specific crops or particular animals.
(18) Neal’s evidence to the committee said Future Fund staff were not subject to the public service bargaining framework, which links any pay rise to productivity increases and caps rises at 1.5%.
(19) We have investigated interactions between the erythroid transcription factor GATA-1 and factors binding two cis-acting elements commonly linked to GATA sites in erythroid control elements.
(20) These studies indicate that at each site of induction during feather morphogenesis, a general pattern is repeated in which an epithelial structure linked by L-CAM is confronted with periodically propagating condensations of cells linked by N-CAM.