(1) The results presented refute arguments that these enzymes proceed by a concerted mechansim and support the intermediacy of aminoacyladenylates.
(2) This inactivation was very rapid but reversible, with regeneration of enzyme activity being spontaneous and hydrazine-accelerated, suggestive of the intermediacy of a stable acyl enzyme.
(3) A series of different related diethoxy-phosphorous-acid derivatives were also synthesized; their (31P)-NMR signals between 123.9 and 130.8 ppm are additional evidence for the intermediacy of a tetrazolide species.
(4) Using [14C]cholesterol-labeled membranes and HPLC with radiodetection, we identified 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide as the major cholesterol photoproduct, thereby confirming 1O2 intermediacy.
(5) A microsomal preparation from seedlings of Zea mays catalyzed the NADPH dependent reduction of the delta 7-bond of delta 5,7-cholestadienol (1) giving the first in vitro evidence for the intermediacy of delta 5,7-sterols in plant sterol biosynthesis.
(6) A number of other related products generated by reaction of cyclase with the analog were also identified, the structures and proportions of which were consistent with the intermediacy in catalysis of a cyclopropylcarbinyl cation X pyrophosphate anion pair.
(7) 262, 962], implied the intermediacy of a substrate imine complex in the catalytic redox mechanism.
(8) The epimerization of ecdysone to 3-epiecdysone has been investigated in a dialysed cytosolic enzyme preparation from midgut of sixth instar Spodoptera littoralis larvae, with particular emphasis on establishing the intermediacy of 3-dehydroecdysone.
(9) These studies are consistent with 1O2 intermediacy in the mechanism of MC540-mediated photosensitization.
(10) If the biological conversion of cholest-7-en-3beta-ol (I) into cholesterol (IV) occurred thorugh the intermediacy of cholest-7-ene-3beta,5alpha-diol (II) then the factor(s) adversely affecting the convwesion of the 5alpha-hydroxy sterol (II) into cholesterol must at least equally adversely affect the formation of cholesterol from cholest-7-en-3beta-ol.
(11) Kinetics for the base-catalyzed hydrolysis of compounds 9--13 were investigated by UV and NMR methods and are considered in connection with service of these compounds as pro(phosphorodiamidic acid mustards) [MP(O)(NHR)OAr leads to MP(O)(NHR)OH] via an E1cB mechanism involving the intermediacy of a mustard-bearing metaphosphorodiimide [MP(O)=NR].
(12) GTP gamma S alone stimulated both the release of free arachidonic acid and production of diacylglycerol (DAG), while EGF itself neither stimulated DAG nor augmented the DAG response to GTP gamma S. These findings suggest the intermediacy of a G-protein in PLC-independent stimulation of PLA2 by a growth factor, and provide a model system for determining the relationship between G-protein intermediacy and the intrinsic tyrosine kinase activity of the growth factor receptor.
(13) However, O2-, H2O2, and iron are all required for lipid peroxidation and nondisulfide crosslinking, suggesting the intermediacy of OH generated via the iron-catalyzed Haber-Weiss reaction.
(14) This interaction suggests that the site of nucleoside attachment is in close proximity to the 12-methyl group and that binding occurs, therefore, through the intermediacy of a 3,4-diol-1,2-oxide, i.e.
(15) Comparison of the yields of CO2 from this series of compounds suggests the intermediacy of malonic semialdehyde in the metabolism of MDA.
(16) The results tend to indicate that progesterone is as good a precursor of cardenolides as pregnenolone It is suggested that the biosynthesis of cardenolides might proceed through the intermediacy of progesterone.
(17) The formation of the 5-bromo derivatives under the reported conditions probably occurred through the intermediacy of the 3,5-acyloxonium ions.
(18) A mechanism for the removal of the 14alpha-methyl group in ergosterol biosynthesis that involves the intermediacy of an 8,14-diene system is outlined.
(19) The results are compatible with the intermediacy of certain of these arene oxides in the metabolic pathway from hydrocarbons to phenols.
(20) Heterozygotes displayed strict intermediacy for all kinetic and structural properties examined.
Intermediate
Definition:
(a.) Lying or being in the middle place or degree, or between two extremes; coming or done between; intervening; interposed; interjacent; as, an intermediate space or time; intermediate colors.
(v. i.) To come between; to intervene; to interpose.
Example Sentences:
(1) In addition, intravenous injection of complexes into rabbits showed optimal myocardial images with agents of intermediate lipophilicity.
(2) In the present investigation we monitored the incorporation of [14C] from [U-14C]glucose into various rat brain glycolytic intermediates of conscious and pentobarbital-anesthetized animals.
(3) Displacement of the enol triflate with various sulfinates in acetonitrile or DMF and deprotection of the intermediates led to 7 beta-[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]- 3-[alkyl(aryl)sulfonyl]-1-carba-1-dethia-3-cephem-4-carboxyl ic acids.
(4) These results are discussed in relation to the possible existence of enzyme-bound intermediates of nitrogen fixation.
(5) Lysis of EAC4b,3b cellular intermediates formed to contain a low surface amount of C3b was more inhibited than was lysis of cells formed with a standard amount of C3b on the surface.
(6) A few free-floating cells could be observed in the lumen of this intermediate portion, most of which were macrophages.
(7) Although temazepam was effective for maintaining sleep with short-term use, there was rapid development of tolerance for this effect with intermediate-term use.
(8) The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes.
(9) Results obtained from cumulative labeling and pulse-labeling and chase experiments with cells from late gastrulae, yolk plug-stage embryos, and neurulae showed that the 30S RNA is an intermediate in rRNA processing and is derived from 40S pre-rRNA and processed to 28S rRNA.
(10) It is possible that the elements provide common precursor proteins that reach the secretory intermediate lobe cells through their dendritic branches.
(11) Grafts of intermediate thickness (M III) showed excellent clinical healing of the donor and the recipient site.
(12) While the heaviest anterogradely labeled ascending projections were observed to the contralateral ventral posterolateral nucleus of the thalamus, pars oralis (VPLo), efferent projections were also observed to the contralateral ventrolateral thalamic nucleus (VLc) and central lateral (CL) nucleus of the thalamic intralaminar complex, magnocellular (and to a lesser extent parvicellular) red nucleus, nucleus of Darkschewitsch, zona incerta, nucleus of the posterior commissure, lateral intermediate layer and deep layer of the superior colliculus, dorsolateral periaqueductal gray, contralateral nucleus reticularis tegmenti pontis and basilar pontine nuclei (especially dorsal and peduncular), and dorsal (DAO) and medial (MAO) accessory olivary nuclei, ipsilateral lateral (external) cuneate nucleus (LCN) and lateral reticular nucleus (LRN), and to a lesser extent the caudal medial vestibular nucleus (MVN) and caudal nucleus prepositus hypoglossi (NPH), and dorsal medullary raphe.
(13) HCT were classified by light microscopy as benign (n = 22), intermediate (n = 30), and malignant (n = 13).
(14) Transient intermediates were distinguished from dead-end metabolites by the rapid formation and disappearance of the former.
(15) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(16) Magnetic polyethyleneimine (PEI) microcapsules have been developed for trapping electrophilic intermediates in the gastrointestinal (GI) tract.
(17) Two different approaches were developed within the framework of Relational LABCOM to address both the intermediate and long-term storage of data.
(18) Confirming a low proliferative activity in CN and a high activity in melanomas (MIS, IM, MM), the results showed that dysplastic nevi (NAA, NCAA) had a proliferative activity intermediate between common nevi and melanomas.
(19) In the medium-size intermediate fibers, the number and diameter of the mitochondrial columns are intermediate between those of the red and white fibers.
(20) ), 24 proteins in the intermediate phase (12-24 h p.i.