(1) The results presented refute arguments that these enzymes proceed by a concerted mechansim and support the intermediacy of aminoacyladenylates.
(2) This inactivation was very rapid but reversible, with regeneration of enzyme activity being spontaneous and hydrazine-accelerated, suggestive of the intermediacy of a stable acyl enzyme.
(3) A series of different related diethoxy-phosphorous-acid derivatives were also synthesized; their (31P)-NMR signals between 123.9 and 130.8 ppm are additional evidence for the intermediacy of a tetrazolide species.
(4) Using [14C]cholesterol-labeled membranes and HPLC with radiodetection, we identified 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide as the major cholesterol photoproduct, thereby confirming 1O2 intermediacy.
(5) A microsomal preparation from seedlings of Zea mays catalyzed the NADPH dependent reduction of the delta 7-bond of delta 5,7-cholestadienol (1) giving the first in vitro evidence for the intermediacy of delta 5,7-sterols in plant sterol biosynthesis.
(6) A number of other related products generated by reaction of cyclase with the analog were also identified, the structures and proportions of which were consistent with the intermediacy in catalysis of a cyclopropylcarbinyl cation X pyrophosphate anion pair.
(7) 262, 962], implied the intermediacy of a substrate imine complex in the catalytic redox mechanism.
(8) The epimerization of ecdysone to 3-epiecdysone has been investigated in a dialysed cytosolic enzyme preparation from midgut of sixth instar Spodoptera littoralis larvae, with particular emphasis on establishing the intermediacy of 3-dehydroecdysone.
(9) These studies are consistent with 1O2 intermediacy in the mechanism of MC540-mediated photosensitization.
(10) If the biological conversion of cholest-7-en-3beta-ol (I) into cholesterol (IV) occurred thorugh the intermediacy of cholest-7-ene-3beta,5alpha-diol (II) then the factor(s) adversely affecting the convwesion of the 5alpha-hydroxy sterol (II) into cholesterol must at least equally adversely affect the formation of cholesterol from cholest-7-en-3beta-ol.
(11) Kinetics for the base-catalyzed hydrolysis of compounds 9--13 were investigated by UV and NMR methods and are considered in connection with service of these compounds as pro(phosphorodiamidic acid mustards) [MP(O)(NHR)OAr leads to MP(O)(NHR)OH] via an E1cB mechanism involving the intermediacy of a mustard-bearing metaphosphorodiimide [MP(O)=NR].
(12) GTP gamma S alone stimulated both the release of free arachidonic acid and production of diacylglycerol (DAG), while EGF itself neither stimulated DAG nor augmented the DAG response to GTP gamma S. These findings suggest the intermediacy of a G-protein in PLC-independent stimulation of PLA2 by a growth factor, and provide a model system for determining the relationship between G-protein intermediacy and the intrinsic tyrosine kinase activity of the growth factor receptor.
(13) However, O2-, H2O2, and iron are all required for lipid peroxidation and nondisulfide crosslinking, suggesting the intermediacy of OH generated via the iron-catalyzed Haber-Weiss reaction.
(14) This interaction suggests that the site of nucleoside attachment is in close proximity to the 12-methyl group and that binding occurs, therefore, through the intermediacy of a 3,4-diol-1,2-oxide, i.e.
(15) Comparison of the yields of CO2 from this series of compounds suggests the intermediacy of malonic semialdehyde in the metabolism of MDA.
(16) The results tend to indicate that progesterone is as good a precursor of cardenolides as pregnenolone It is suggested that the biosynthesis of cardenolides might proceed through the intermediacy of progesterone.
(17) The formation of the 5-bromo derivatives under the reported conditions probably occurred through the intermediacy of the 3,5-acyloxonium ions.
(18) A mechanism for the removal of the 14alpha-methyl group in ergosterol biosynthesis that involves the intermediacy of an 8,14-diene system is outlined.
(19) The results are compatible with the intermediacy of certain of these arene oxides in the metabolic pathway from hydrocarbons to phenols.
(20) Heterozygotes displayed strict intermediacy for all kinetic and structural properties examined.
Intervention
Definition:
(n.) The act of intervening; interposition.
(n.) Any interference that may affect the interests of others; especially, of one or more states with the affairs of another; mediation.
(n.) The act by which a third person, to protect his own interest, interposes and becomes a party to a suit pending between other parties.
Example Sentences:
(1) In dogs, cibenzoline given i.v., had no effects on the slow response systems, probably because of sympathetic nervous system intervention since the class 4 effects of cibenzoline appeared after beta-adrenoceptor blockade.
(2) On the basis of 180 interventions, they describe in detail the use of fibrin glue in myringo- and tympanoplasty for correct fixing of grafts.
(3) As important providers of health care education, nurses need to be fully informed of the research findings relevant to effective interventions designed to motivate health-related behavior change.
(4) Results in May 89 emphasizes: the relevance and urgency of the prevention of AIDS in secondary schools; the importance of the institutional aspect for the continuity of the project; the involvement of the pupils and the trainers for the processus; the feasibility of an intervention using only local resources.
(5) Benefits increase with an individual's initial cholesterol level and decrease with the age at which an intervention is initiated.
(6) Many features of CFTR activity suggest that pharmacological interventions may be possible.
(7) The methodology, in algorithm form, should assist health planners in developing objectives and actions related to the occurrence of selected health status indicators and should be amenable to health care interventions.
(8) In conclusion, autoimmune thyroiditis in an animal model can be prevented by reducing thyroidal iodine or its metabolism and optimal effects require intervention at the embryonic stage.
(9) We found no statistically significant difference in one-year, biochemically validated, sustained cessation rates between the group offered the long-term follow-up visits (12.5%) and the group given the brief intervention (10.2%).
(10) The experiences with short-time psychotherapies described here are encouraging and confirm results of other groups demonstrating the efficiency of psychotherapeutic interventions with the elderly.
(11) Survival and healing of "extremely severe" grade intoxication can only be obtained through a surgical intervention within the first hours; a laparotomy will indicate the depth of the lesions, which is not determined by endoscopy, and will consist of Celerier's stripping method and if necessary a gastrectomy, more seldom a cephalic duodeno-pancreatectomy.
(12) Occupational income per patient was higher in intervention patients than in the usual care group in the 6 months after AMI ($9,655 vs $7,553).
(13) The morbidity is well known and if properly anticipated can be reduced to a minimum by judicious use of antibacterial agents and early surgical intervention when appropriate.
(14) Ex-patients of a dental fear clinic were found to have significantly reduced, yet still high, dental anxiety scores in comparison with the pre-intervention scores.
(15) After an introductory note on primary preventive intervention of breast cancer during adulthood, the author defends and extends a hypothesis that relates most of the known risk factors for this disease to the development of preneoplastic lesions in the breast.
(16) It is concluded that based on readily available clinical criteria at the time of admission, a subgroup of patients at low risk for developing life-threatening complications requiring coronary care unit interventions can be identified and admitted directly to an intermediate-care unit.
(17) A therapeutic approach is suggested which emphasizes specific antibiotic regimens appropriate to the primary site of infection and prompt neurosurgical intervention with evacuation of the subdural spaces bilaterally.
(18) The need for follow-up studies is stressed to allow assessment of the effectiveness of the intervention and to search for protective factors, successful coping skills, strategies and adaptational resources.
(19) Families were randomly assigned to one of two forms of conjoint therapy: an Insight-oriented treatment (N = 10) or a Problem-Solving intervention (N = 10).
(20) Implications for assessment intervention and prevention were discussed and further research suggested.