(1) In contrast, DNA polymerase alpha, the enzyme involved in chromosomal DNA replication, was relatively insensitive to CA1.
(2) These variants may serve as useful gene markers in alcohol research involving animal model studies with inbred strains in mice.
(3) In 49 cases undergoing systemic lymphadenectomy 32 were found to have glandular involvement, of which both aortic and pelvic nodes were positive in 17 cases (53.1%), aortic nodes positive but pelvic negative in six (18.8%), and pelvic nodes positive but aortic negative in nine (28.1%).
(4) Cellulase regulation appears to depend upon a complex relationship involving catabolite repression, inhibition, and induction.
(5) Clonal abnormalities involving chromosomes 3 and 21 were noted in two patients.
(6) Disseminated CMV infection with multiorgan involvement was evident in 7 of 9 at postmortem examination.
(7) It is concluded that amlodipine reduces myocardial ischemic injury by mechanism(s) that may involve a reduction in myocardial oxygen demand as well as by positively influencing transmembrane Ca2+ fluxes during ischemia and reperfusion.
(8) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(9) Comparison of wild type and the mutant parD promoter sequences indicated that three short repeats are likely involved in the negative regulation of this promoter.
(10) This diagnosis was obscured by the absence of cutaneous, oropharyngeal, and respiratory involvement.
(11) A progressively more precise approach to identifying affected individuals involves measuring body weight and height, then energy intake (or expenditure) and finally the basal metabolic rate (BMR).
(12) It would be fascinating to see if greater local government involvement in running the NHS in places such as Manchester leads over the longer term to a noticeable difference in the financial outlook.
(13) It involves creativity, understanding of art form and the ability to improvise in the highly complex environment of a care setting.” David Cameron has boosted dementia awareness but more needs to be done Read more She warns: “To effect a cultural change in dementia care requires a change of thinking … this approach is complex and intricate, and can change cultural attitudes by regarding the arts as central to everyday life of the care home.” Another participant, Mary*, a former teacher who had been bedridden for a year, read plays with the reminiscence arts practitioner.
(14) The secondary leukemia that occurred in these patients could be distinguished from the secondary leukemia that occurs after treatment with alkylating agents by the following: a shorter latency period; a predominance of monocytic or myelomonocytic features; and frequent cytogenetic abnormalities involving 11q23.
(15) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(16) The present study was therefore carried out to specify further which type of adrenoceptor is involved in lithium-induced hyperglycaemia and inhibition of insulin secretion.
(17) The stages of mourning involve cognitive learning of the reality of the loss; behaviours associated with mourning, such as searching, embody unlearning by extinction; finally, physiological concomitants of grief may influence unlearning by direct effects on neurotransmitters or neurohormones, such as cortisol, ACTH, or norepinephrine.
(18) These results suggest the involvement of SRC in opsin transport.
(19) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(20) Epidemiological studies on low risks involve a number of major methodological difficulties.
Knotty
Definition:
(superl.) Full of knots; knotted; having many knots; as, knotty timber; a knotty rope.
(superl.) Hard; rugged; as, a knotty head.
(superl.) Difficult; intricate; perplexed.
Example Sentences:
(1) Andrew Romano, Newsweek How would these eloquent know-it-alls – these brainiacs bent on "speaking truth to stupid" – untangle the knotty threads of information that make actual breaking news so difficult to sort out?
(2) It originally quoted Kathryn Bigelow as saying "naughty subjects" rather than "knotty subjects"
(3) For example, 1 group, "knotty amacrine cells," has small cell bodies and a profusion of small, varicose, intertwined processes that span up to 30 microns and are essentially monostratified, but each of the 3 types ends in different strata.
(4) He has friendly, wide-set eyes, a burst of knotty dreadlocks and a gnarled scar just below his jaw, from when he fell from a low wire as a child and impaled himself on the protruding end of a metal coil.
(5) She was a sane voice that could be relied upon to help them make sense of the knotty complications of their personal, sexual lives.
(6) Eight cases were reported in order to elucidate the important role of electron microscopy (EM) played in diagnosis of knotty tumors.
(7) What do you think they can buy for that?” Kasich also raised the other knotty problem that is causing divisions within the Republican party: preexisting conditions.
(8) The A1 cells are small axonless neurons with knotty and dense dendritic trees.
(9) This is potentially a knotty problem, but a few points seem to suggest that Wales's concerns are overdone.
(10) Bloomberg Associates, as he is calling his private consultancy, will be what the New York Times has called an “urban SWAT team” that will be called in by struggling cities to help solve their knotty problems absolutely free of charge.
(11) Updated at 9.37pm BST 8.47pm BST A novel Peace Prize idea This is interesting - European leaders have apparently been considering the knotty problem of who should pick up the Nobel Peace Prize in December.
(12) There is a knotty ethical problem underlying such arguments.
(13) Subjects ranged from the English civil war in The Staffordshire Rebels (1965) and local railways in The Knotty (1966) to the audience's second world war memories in Hands Up!
(14) This knotty and discomforting genealogy that binds Englishness to empire and slavery and their fractious legacies of racism and inequality seems to be too thought-provoking for Gove's deeply conservative vision of English literature.
(15) But it would help his cause, the lawyer argued, by addressing several of the knotty issues related to his future.
(16) Every time a party has looked at this problem, it’s been too knotty to unpick and it has given up.
(17) What distinguishes this recession from those we have seen before is one particularly knotty fact: unemployment has increased a good deal more than employment has fallen.
(18) Only a better understanding of their pathogenesis, and of how the glomerulus normally retains plasma protein, will solve this knotty problem.
(19) The prospect of Erdoğan unbound suggests a number of other knotty problems may become more intractable.
(20) Canary Wharf – modernist, faceless, towering – houses the mighty investment banks; the City – quirky, crowded, knotty, historic – has the brokers, insurers and ancillary services; Mayfair – discreet, stylish, cosmopolitan – is home to the hedge funds and private equity companies.