(1) In contrast, DNA polymerase alpha, the enzyme involved in chromosomal DNA replication, was relatively insensitive to CA1.
(2) These variants may serve as useful gene markers in alcohol research involving animal model studies with inbred strains in mice.
(3) In 49 cases undergoing systemic lymphadenectomy 32 were found to have glandular involvement, of which both aortic and pelvic nodes were positive in 17 cases (53.1%), aortic nodes positive but pelvic negative in six (18.8%), and pelvic nodes positive but aortic negative in nine (28.1%).
(4) Cellulase regulation appears to depend upon a complex relationship involving catabolite repression, inhibition, and induction.
(5) Clonal abnormalities involving chromosomes 3 and 21 were noted in two patients.
(6) Disseminated CMV infection with multiorgan involvement was evident in 7 of 9 at postmortem examination.
(7) It is concluded that amlodipine reduces myocardial ischemic injury by mechanism(s) that may involve a reduction in myocardial oxygen demand as well as by positively influencing transmembrane Ca2+ fluxes during ischemia and reperfusion.
(8) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(9) Comparison of wild type and the mutant parD promoter sequences indicated that three short repeats are likely involved in the negative regulation of this promoter.
(10) This diagnosis was obscured by the absence of cutaneous, oropharyngeal, and respiratory involvement.
(11) A progressively more precise approach to identifying affected individuals involves measuring body weight and height, then energy intake (or expenditure) and finally the basal metabolic rate (BMR).
(12) It would be fascinating to see if greater local government involvement in running the NHS in places such as Manchester leads over the longer term to a noticeable difference in the financial outlook.
(13) It involves creativity, understanding of art form and the ability to improvise in the highly complex environment of a care setting.” David Cameron has boosted dementia awareness but more needs to be done Read more She warns: “To effect a cultural change in dementia care requires a change of thinking … this approach is complex and intricate, and can change cultural attitudes by regarding the arts as central to everyday life of the care home.” Another participant, Mary*, a former teacher who had been bedridden for a year, read plays with the reminiscence arts practitioner.
(14) The secondary leukemia that occurred in these patients could be distinguished from the secondary leukemia that occurs after treatment with alkylating agents by the following: a shorter latency period; a predominance of monocytic or myelomonocytic features; and frequent cytogenetic abnormalities involving 11q23.
(15) In addition to their involvement in thrombosis, activated platelets release growth factors, most notably a platelet-derived growth factor (PDGF) which may be the principal mediator of smooth muscle cell migration from the media into the intima and of smooth muscle cell proliferation in the intima as well as of vasoconstriction.
(16) The present study was therefore carried out to specify further which type of adrenoceptor is involved in lithium-induced hyperglycaemia and inhibition of insulin secretion.
(17) The stages of mourning involve cognitive learning of the reality of the loss; behaviours associated with mourning, such as searching, embody unlearning by extinction; finally, physiological concomitants of grief may influence unlearning by direct effects on neurotransmitters or neurohormones, such as cortisol, ACTH, or norepinephrine.
(18) These results suggest the involvement of SRC in opsin transport.
(19) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(20) Epidemiological studies on low risks involve a number of major methodological difficulties.
Tangled
Definition:
(imp. & p. p.) of Tangle
Example Sentences:
(1) The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy.
(2) It was the ease with which minor debt could slide into a tangle of hunger and despair.
(3) Although a trend was observed for TMA-DPH mobility to parallel histopathologic severity in hippocampal specimens, the biophysical changes did not appear to reflect a loss of neuronal membranes relative to glial membranes or the presence of senile plaques or neurofibrillary tangles.
(4) Neurofibrillary tangles (NFT), one of the pathological hallmarks of Alzheimer's disease are observed in very high densities in the brains of former professional boxers suffering from dementia pugilistica.
(5) Elevated brain Al concentrations, especially in cortical regions, were associated with behavioral changes and the development of neurofibrillary tangles (NFTs).
(6) The smoky density of the mackerel was nicely offset by the pointed black olive tapenade and the fresh, zingy flavours present in little tangles of tomato, shallot, red pepper and spring onion, a layer of pea shoots and red chard, and the generous dressing of grassy olive oil.
(7) Changes were more severe in white matter close to cortical areas with a great density of neurofibrillary tangles.
(8) There is a tangled web between Salazar, Nike, Farah and the Nike Oregon Project on one hand, and the British Athletics performance director, Neil Black, and head of endurance, Barry Fudge, on the other.
(9) Whereas cortical senile plaque count did not distinguish well between demented and nondemented subjects, every subject with numerous cortical neurofibrillary tangles was demented.
(10) Clinical symptoms of amnesia appear when amyloid induces neighbouring neuritic alterations: paired helical filaments and distant neuronal body lesions: neurofibrillary tangles.
(11) Staggerer cerebellar cortex exhibits the greatest fluorescence with most terminals appearing as matted tangles adjacent cell bodies.
(12) Tangle-free neurons in both diseased and control brains showed weak to absent intracytoplasmic immunoreactivity.
(13) But tangled up in its visions of thousands of new “starter homes” – 5,000 more of which were promised on Monday, when the government said it was going to directly commission housebuilding on five sites in the south of England – are an array of drastic measures aimed at what remains of England’s council homes.
(14) The capacity for protein synthesis in tangled cells appears, therefore, to be progressively decreased with accumulation of tangle, whereas that for oxidative metabolism is maintained and lysosomal activity, perhaps, increased.
(15) On electron microscopy the normal lamellar pattern made up of orientated collagen fibrils all about 80 nm diameter is replaced by a random tangled pattern of much thinner irregularly curved fibrils, some as thin as 5nm.
(16) Eight brains failed to reveal considerable numbers of neuritic plaques, neurofibrillary tangles, and neuropil threads, but these brains showed the presence of abnormal and intensely argyrophilic grains loosely scattered throughout the neuropil.
(17) N-Terminal and C-terminal domains of tau were found to be present in tangles in situ.
(18) The neuropathological lesions were assessed using a fluorescent stain for neuritic plaques and neurofibrillary tangles.
(19) However, increased knowledge concerning macromolecular abnormalities in amyloid containing plaques and neurofibrillary tangles makes the outlook for a diagnostic test for AD on CSF promising.
(20) The trial, originally expected to be staid, has exposed severe dysfunction within Bo's family and detailed the complicated tangle of allegiances and affairs that led to his downfall .