(n.) The quality or state of being irascible; irritability of temper; irascibleness.
Example Sentences:
(1) I learned that the hard way: when I was younger, I played the part of the erratic, irascible drunk in order to have something to write about.
(2) All round Europe there have been political earthquakes in a volatile anti-politics age: the surprise is that Britain’s scratchy, irascible electorate hasn’t expressed its underlying anger that ordinary people paid the price for the bankers’ crash.
(3) Kaczyński is behaving like Józef Piłsudski, the brilliant but irascible prewar leader who brought Poland back to independence in 1918.
(4) The mother is irascible, the father aloof; on the other hand, the parental combination "mother and father affectionate" is more common.
(5) The ability to be a good listener, unflappable and patient enough to deal with irascible family members, mediating family spats and calming ruffled feathers also helps.
(6) But she's not bad as the partner of an Iraq-bound soldier in Timeless: perhaps a bit plummier than you might expect a squaddie's wife required to live with her irascible great-grandmother in a tiny house to be, but certainly nothing like the disaster the world has come to expect from supermodels demonstrating their polymath abilities.
(7) Nancy's novels and Jessica's memoirs offered a beguiling - and friends thought - inaccurate picture of the extraordinary life lived out chez Mitford under the irascible gaze of Lord Redesdale ("Uncle Matthew" in Love in a Cold Climate), celebrated for his dislike of foreigners and his daughters' friends, disparaged collectively as "sewers".
(8) In 1959, he starred in Carol Reed's Our Man In Havana, and a year later gave a brilliantly unpleasant Scottish impersonation of an irascible soldier in Tunes Of Glory.
(9) Known for his irascibility, the writer has in one sense softened in late middle age.
(10) Now the Newsnight presenter Jeremy Paxman, famous for giving ruthlessly short shrift to politicians, has confirmed that his irascible on-screen attitude towards Westminster is more than skin deep.
(11) But his less enthusiastic answer about Bannon comes amid reports of infighting in the Trump White House, all of which place the gruff, irascible Bannon at the center.
(12) The clinico-pathological characteristics of the case were as follows: Fibrillary gliosis of the midbrain and pontine reticular formation corresponded clinically to personality changes: The patient had formerly been irascible and became extremely mild-mannered.
(13) All good knockabout stuff and the makings of a legend - irascible, menacing, self-important, egoistical.
(14) His father was an irascible, blind barrister, the Mortimer of Mortimer on Wills, Probate and Divorce.
(15) Yet, if you speak to some at Shirebrook, she seems to portray an image that can be as irascible as charming.
(16) Though more conservative in his politics, McAvoy, with his irascible personality and his unfortunate attitude to authority, is thought to be based on the former MSNBC news host Keith Olbermann, who quit the network after a very public falling-out, going then to the upstart Current TV channel, which he left in March this year after another row with the management.
(17) Typical Munchausen behaviors such as irascibility, the desperate search for care, and pseudologia fantastica, may be understood as solutions to problems created by brain damage.
(18) Wrestling with an opponent who will not recognise the prejudice in a phrase like "hideous Jewish face" had finally pushed Rampton, who cultivates a manner of curmudgeonly irascibility, into a foul mood.
(19) What is quickly turning into a public relations nightmare for the irascible Rodman – whose fellow players looked like they would rather be anywhere but Pyongyang during his tetchy pre-game interview with CNN on Tuesday – can only have helped burnish Kim's reputation, at least at home.
(20) It was an unexpected flash of humanity from this irascible stickler for social propriety.
Spleen
Definition:
(n.) A peculiar glandlike but ductless organ found near the stomach or intestine of most vertebrates and connected with the vascular system; the milt. Its exact function in not known.
(n.) A sudden motion or action; a fit; a freak; a whim.
(n.) Melancholy; hypochondriacal affections.
(n.) A fit of immoderate laughter or merriment.
(v. t.) To dislke.
Example Sentences:
(1) At the early phase of the sensitization a T-cell response was seen in vitro, characterized by an increased spleen but no peripheral blood lymphocyte reactivity to T-cell mitogens at the same time as increased reactivity to the sensitizing antigen was detected.
(2) Most of the radioactivity in spleen cells from these rats were associated with antigen-reactive cells which formed rosettes specifically with HO erythrocytes.
(3) Reactive metabolites which suppress splenic humoral immune responses are thought to be generated within the spleen rather than in distant tissues.
(4) Pokeweed mitogen-stimulated rat spleen cells were identified as a reliable source of rat burst-promoting activity (PBA), which permitted development of a reproducible assay for rat bone marrow erythroid burst-forming units (BFU-E).
(5) Release of 51Cr was apparently a function of immune thymus-derived lymphocytes (T cells) because it was abrogated by prior incubation of spleen cells with anti-thymus antiserum and complement but was undiminished by passage of spleen cells through nylon-wool columns.
(6) Moreover, the data showed for the first time that DNA synthesis in the bone marrow and spleen and colon were markedly statistically significantly stimulated at specific times after treatment.
(7) High radioactivities were observed in the digestive organs, mesenteric lymphnodes, liver, pancreas, urinary bladder, fat tissue, kidney and spleen after oral administration to rats.
(8) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(9) Proliferation of quiescent hematopoietic stem cells, purified by cell sorting and evaluated by spleen colony assay (CFU-S), was investigated by measuring the total cell number and CFU-S content and the DNA histogram at 20 and 48 hours of liquid culture.
(10) In investigation of AMLR composed of peripheral blood cells and spleen cells of gastric cancer patient, AMLR on splenic non-T cells as a stimulator was significantly suppressed compared with peripheral blood non-T cells as a stimulator.
(11) During the development of Shvets' leukosis, the weight of spleen and lymph glands and their lymphocyte content change enormously while the number of plasmocytes rises exponentially.
(12) A constellation of histologic lesions was identified in brain (diffuse meningoencephalitis with bilaterally symmetrical thalamic necrosis), liver (pericholangiohepatitis), lung (pneumonitis), and spleen (lymphoid hyperplasia); this tetrad is apparently unique to this model system.
(13) The bursa of Fabricius, thymus glands and spleen of chickens were also shown to express mRNA coding for ANP.
(14) For routine use, 50 mul of 12% BTV SRBC, 0.1 ml of a spleen cell suspension, and 0.5 ml of 0.5% agarose in a balanced salt solution were mixed and plated on a microscope slide precoated with 0.1% aqueous agarose.
(15) Polyadenylic-polyuridylic acid complexes (poly A:U) at the 1-5 mu g level, were mitogenic for spleen cells when given intravenously to normal Balb or cortisone-treated mice.
(16) Mixing experiments were performed to test the putative inhibitory effects of allotype-suppressed spleen cells from the first adoptive transfer (stage I) on the antibody response of normal spleen cells in a second adoptive transfer (stage II).
(17) After birth, it was in the liver and spleen up to 6 weeks af age, and thereafter it was present only in the bone marrow.
(18) Only the group that received 3R spleen cells treated with anti I-Jb monoclonal antibody and C' had no suppressed PFC.
(19) Prior incubation of these antigens with test spleen cells in the agar gel effictively inhibited development of the vibriolytic plaques, regardless of antibody class.
(20) Four hours after injection radioactivity was identified in the spleen, liver, and bone marrow.