(v. t.) To weary; to give pain; to annoy; -- used only impersonally at present.
Example Sentences:
(1) When the rats were grouped into animals with mild (20%), moderate (50%), and severe (80%) reductions in maximal IRK activity, it was found that the mild and moderate defects could be reversed once the receptors were subjected to extensive autophosphorylation in vitro.
(2) We characterized the mechanism of IRK inhibition and studied whether it is the consequence of a glucose-induced stimulation of protein kinase C (PKC).
(3) 18 May 2014 New £69.4bn proposal, worth £55 a share, piles pressure on AstraZeneca's board to enter negotiations with Pfizer 19 May 2014 AstraZeneca board rejects Pfizer's final £69bn takeover bid , irking some large shareholders
(4) Reports of George’s stag do at Ristorante da Ivo near St Mark’s Square with the free £3,000 meal featuring six flavours of ice cream, including takeaway cartons, initially irked me.
(5) Joleon Lescott last weekend irked supporters by clumsily saying relegation was a “weight off the shoulders”.
(6) Wenger must be the only manager in football to be irked by reports that he will be offered a new deal.
(7) Walking by last Monday, Trump gestured towards an image of his inauguration crowd – a point that still irks him – and told reporters there would soon be an official statement about the future of his national security adviser, Michael Flynn.
(8) Blogger Yomi Adegoke said: "Thinly veiling vanity as philanthropy more than irks … the pretence these images are for anything other than an onslaught of 'natural beauty' acclamations, coupled with pats on the back for 'fighting the cause' makes the no makeup selfie mania even harder to stomach."
(9) We, therefore, conclude that glucose intolerance in aging could be attributed at least in part to acquired defects in the in vivo activation of the hepatic IRK, which results in reduced phosphorylation of its putative substrate pp180.
(10) But while agreeing that the results should not be exaggerated, D'Alimonte still thinks they indicate that the Five Star shine is wearing off among some voters - including those who were irked by the rambunctious figurehead's refusal to support a minority government led by the centre-left Democratic party (PD), thus forcing the PD to form a coalition with Berlusconi's centre-right.
(11) The corporation's power online and expanding digital TV and radio channels have irked beleaguered commercial rivals, resulting in an attack by James Murdoch, head of News Corporation in the UK.
(12) The home crowd turned their ire on the Hungarian referee Viktor Kassai – his decision to dismiss Piiroja for handball in the 76th minute particularly irked them – but they were deluding themselves if they thought he was to blame.
(13) Right now is not the time.” The midfielder refused to be drawn on suggestions that his team-mates were irked by his comments, and insisted the atmosphere among the squad in Brazil was similar to during the glorious Euro 2012 campaign.
(14) Hyperglycemia causes insulin-receptor kinase (IRK) resistance in fat cells.
(15) The comments irked the geologists' professional body, which was founded in 1807 as a dining club in a London pub.
(16) Philip Hammond appears to have irked the prime minister by making a sexist remark in cabinet, exposing the tensions at the highest level of government.
(17) Look, he’s the clear frontrunner, he’s been in six debates already, answered more questions from the media than any other candidate on the stage combined.” The Fox News press release that irked Trump and led to his withdrawal read: “We learned from a secret back channel that the Ayatollah and Putin both intend to treat Donald Trump unfairly when they meet with him if he becomes president – a nefarious source tells us that Trump has his own secret plan to replace the Cabinet with his Twitter followers to see if he should even go to those meetings.” Trump derided it as “a wise guy press release .
(18) To determine whether defects in insulin receptor kinase (IRK) activity or in the phosphorylation of its physiological substrates underlie this age-related phenomenon, young (2-3 months old) and old (24-27 months old) Wistar rats were studied.
(19) Field has already irked the medallion stallion with some low blows before the bell has rung, but it looks doubtful whether punches will be pulled for the number crunchers.
(20) Linehan, who turned 44 last week, is irked by the persistence of the idea that the sitcom that brought him and Arthur Mathews to the attention of millions has canned laughter on it.
Irksome
Definition:
(a.) Wearisome; tedious; disagreeable or troublesome by reason of long continuance or repetition; as, irksome hours; irksome tasks.
(a.) Weary; vexed; uneasy.
Example Sentences:
(1) "Well, it is slightly irksome when people try to compare the two.
(2) Peter Barlow's son, Our Simon, is particularly irksome, and Faye, who has been used to address the issue of bullying, has it coming.
(3) In Manhattan, she is cast as a pretentious, irksome snob of a journalist.
(4) After a prolonged chuckle, Russell drops his impersonation of Groundhog Day's irksome insurance salesman, a minor but intensely memorable character, and explains excitedly that he recently met Andie MacDowell, one of the film's stars.
(5) As the Press Association reports, he told a committee that said sticking to international rules could be "irksome" at times.
(6) Then, in 2010, he was cast in Friday Night Dinner, getting the part of irksome estate agent Jonny, he thinks, because "I was the most annoying person they could find."
(7) The suggestion that Bastille's fans somehow aren't proper music fans is, understandably, particularly irksome.
(8) The obligation to remember is inscribed on every Holocaust memorial, but even the words "Never Forget" become irksome eventually.
(9) The pathophysiology of this frequent and irksome complication is still poorly understood.
(10) They owe me a medal for trying to save the Russian environment," he said, "The amnesty is just a way for the authorities to save face but we are still described as violent criminals that the Duma, in its magnanimity, is willing to pardon, which is really irksome."
(11) In a letter to the prime minister, the Committee to Protect Journalists (CPJ) said that tighter controls on British newspapers would send the wrong message to repressive regimes that want to "rein in irksome reporters".
(12) It may also say something about modern debate that the most teeth-grinding aspect of Osborne's move barely attracted comment – but the spectacle of an alumnus of St Paul's School worth an estimated £4m kicking the poor in order to preserve his political skin is irksome, to say the least.
(13) It’s not like Thailand today.” Harking back to an idealised past, when irksome democracy was containable and everyone knew their place, is one of the festival’s aims.
(14) When the increasingly irksome backbench rebel Barry Sheerman put in a good 10 minutes on the BBC News Channel, did he not realise the absurdity of his failure to mention a single substantial item of policy?
(15) For Campbell, the justification of the cost is almost as irksome as the outlay itself.
(16) Assessment of completeness of vagotomy has always been an irksome and time-consuming affair.
(17) There is a spread sheet that will tell you what everyone should be doing for every hour over Christmas, from who is doing the driving, through seating plans, to thank-you letters (you have to write down who the last present was from before you are allowed to open the next one – very irksome for The Twins).
(18) This shunts the cost from one government department to another, with the irksome side-effect that the cost is much greater.
(19) Our cause was noble, he submits: we were fighting for European freedom against irksomely expansionist Teutonic tyranny.
(20) Almost as irksome has been a £440,000 cash allowance – separate from Bailey's £1.1m salary and potential £2.2m bonus – plus an additional one-off performance related award of £7.6m worth of shares when he took over as chief executive in May.