(v. t.) To weary; to give pain; to annoy; -- used only impersonally at present.
Example Sentences:
(1) When the rats were grouped into animals with mild (20%), moderate (50%), and severe (80%) reductions in maximal IRK activity, it was found that the mild and moderate defects could be reversed once the receptors were subjected to extensive autophosphorylation in vitro.
(2) We characterized the mechanism of IRK inhibition and studied whether it is the consequence of a glucose-induced stimulation of protein kinase C (PKC).
(3) 18 May 2014 New £69.4bn proposal, worth £55 a share, piles pressure on AstraZeneca's board to enter negotiations with Pfizer 19 May 2014 AstraZeneca board rejects Pfizer's final £69bn takeover bid , irking some large shareholders
(4) Reports of George’s stag do at Ristorante da Ivo near St Mark’s Square with the free £3,000 meal featuring six flavours of ice cream, including takeaway cartons, initially irked me.
(5) Joleon Lescott last weekend irked supporters by clumsily saying relegation was a “weight off the shoulders”.
(6) Wenger must be the only manager in football to be irked by reports that he will be offered a new deal.
(7) Walking by last Monday, Trump gestured towards an image of his inauguration crowd – a point that still irks him – and told reporters there would soon be an official statement about the future of his national security adviser, Michael Flynn.
(8) Blogger Yomi Adegoke said: "Thinly veiling vanity as philanthropy more than irks … the pretence these images are for anything other than an onslaught of 'natural beauty' acclamations, coupled with pats on the back for 'fighting the cause' makes the no makeup selfie mania even harder to stomach."
(9) We, therefore, conclude that glucose intolerance in aging could be attributed at least in part to acquired defects in the in vivo activation of the hepatic IRK, which results in reduced phosphorylation of its putative substrate pp180.
(10) But while agreeing that the results should not be exaggerated, D'Alimonte still thinks they indicate that the Five Star shine is wearing off among some voters - including those who were irked by the rambunctious figurehead's refusal to support a minority government led by the centre-left Democratic party (PD), thus forcing the PD to form a coalition with Berlusconi's centre-right.
(11) The corporation's power online and expanding digital TV and radio channels have irked beleaguered commercial rivals, resulting in an attack by James Murdoch, head of News Corporation in the UK.
(12) The home crowd turned their ire on the Hungarian referee Viktor Kassai – his decision to dismiss Piiroja for handball in the 76th minute particularly irked them – but they were deluding themselves if they thought he was to blame.
(13) Right now is not the time.” The midfielder refused to be drawn on suggestions that his team-mates were irked by his comments, and insisted the atmosphere among the squad in Brazil was similar to during the glorious Euro 2012 campaign.
(14) Hyperglycemia causes insulin-receptor kinase (IRK) resistance in fat cells.
(15) The comments irked the geologists' professional body, which was founded in 1807 as a dining club in a London pub.
(16) Philip Hammond appears to have irked the prime minister by making a sexist remark in cabinet, exposing the tensions at the highest level of government.
(17) Look, he’s the clear frontrunner, he’s been in six debates already, answered more questions from the media than any other candidate on the stage combined.” The Fox News press release that irked Trump and led to his withdrawal read: “We learned from a secret back channel that the Ayatollah and Putin both intend to treat Donald Trump unfairly when they meet with him if he becomes president – a nefarious source tells us that Trump has his own secret plan to replace the Cabinet with his Twitter followers to see if he should even go to those meetings.” Trump derided it as “a wise guy press release .
(18) To determine whether defects in insulin receptor kinase (IRK) activity or in the phosphorylation of its physiological substrates underlie this age-related phenomenon, young (2-3 months old) and old (24-27 months old) Wistar rats were studied.
(19) Field has already irked the medallion stallion with some low blows before the bell has rung, but it looks doubtful whether punches will be pulled for the number crunchers.
(20) Linehan, who turned 44 last week, is irked by the persistence of the idea that the sitcom that brought him and Arthur Mathews to the attention of millions has canned laughter on it.
Irritate
Definition:
(v. t.) To render null and void.
(v. t.) To increase the action or violence of; to heighten excitement in; to intensify; to stimulate.
(v. t.) To excite anger or displeasure in; to provoke; to tease; to exasperate; to annoy; to vex; as, the insolence of a tyrant irritates his subjects.
(v. t.) To produce irritation in; to stimulate; to cause to contract. See Irritation, n., 2.
(n.) To make morbidly excitable, or oversensitive; to fret; as, the skin is irritated by friction; to irritate a wound by a coarse bandage.
(a.) Excited; heightened.
Example Sentences:
(1) Postpartum management is directed toward decreasing vasospasm and central nervous system irritability and maintaining fluid and electrolyte balance.
(2) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
(3) It was shown that the antibiotic had low acute toxicity, did not cumulate and had no skin-irritating effect.
(4) Inhibition of binding of [3H]TPA to the receptor preparation by tigliane and ingenane DTE correlates with irritant activity in vivo, while some daphnane and 1 alpha-alkyldaphnane DTE inhibit binding of [3H]TPA in a less pronounced manner but still are very irritant.
(5) Exposure to irritants was also more common among the asthmatics than the nonasthmatics with similar exposure to organic allergens (P = 0.004).
(6) The purpose of this study was to develop a new model for the induction of chronic irritant contact dermatitis, which would reflect well the conditions of daily practice.
(7) The drug I started taking caused an irritating, chronic cough, which disappeared when I switched to an inexpensive diuretic.
(8) These injections led to epidermal hyperplasia in areas overlying the irritant and the effect was most significant when the irritant was placed in the upper dermis.
(9) Two children required lidocaine therapy for cardiac irritability manifesting as multifocal PVCs and ventricular tachycardia.
(10) In autumn, leaf-heaps composted themselves on sunken patios, and were shovelled up by irritated owners of basement flats.
(11) The dietary fibre intake of 25 patients with the irritable bowel syndrome was assessed by dietary recall over one week for the period before onset of symptoms, at diagnosis and after six months treatment with bran and a fibre-rich diet, and compared with controls matched for age and sex.
(12) A case of epidermoid tumor of the sacral area with S3 root irritation resulting in bladder dysfunction is presented and its possible relationship to spinal puncture is discussed.
(13) The present study did not identify any baseline parameters such as initial prostate volume, peak flow rates, or obstructive or irritative symptom scores that correlated with clinical outcome.
(14) Scores on the "dependent smoking" subscale of the smoking motivation questionnaire correlated significantly with overall withdrawal severity, craving, and increased irritability.
(15) The airways can be affected by inflammation, can be targets of infection, and can respond to chemical irritants with bronchoconstrictive responses.
(16) Some pulp irritation can occur if deep restorations are not placed over a protective film.
(17) MIDAZOLAM IS SUPERIOR TO DIAZEPAM IN CERTAIN WAYS: it has a more rapid onset; produces greater anterograde amnesia, less postoperative drowsiness, less venous irritation and less likelihood of thrombophlebitis development.
(18) Primary invasive adenocarcinoma of the bladder was diagnosed in a fifty-two-year-old male with a two-month history of irritative voiding symptoms.
(19) We studied seventy patients, 23 males and 47 females with irritable bowel syndrome in adolescence aged 13-19 yrs, who visited the department of psychosomatic medicine in Takano Hospital during about six year period of April, 1986-July, 1992.
(20) The study suggested that 1) diabetes and "prediabetes" produce significant changes in levels of chondroitin 4, 6, and dermatan sulfates within alveolar bone, 2) in "prediabetic" animals, interdental bone loss occurs prior to the onset of clinical symptoms and in the absence of local irritating factors, the bone height appears to return to normal levels, and 3) there may be a correlation between alveolar bone height and relative levels of dermatan sulfate.