(a.) Not retrievable; irrecoverable; irreparable; as, an irretrievable loss.
Example Sentences:
(1) Anaerobically, lactaldehyde is reduced by an NADH-COUPLED REDUCTASE TO L-1,2-propanediol, which is lost into the medium irretrievably, even when oxygen is subsequently introduced.
(2) To define more clearly a salvageable patient for possible utilization of a left ventricular assist device prior to multiple organ failure and irretrievability during postcardiotomy intra-aortic balloon pumping (IABP), we made prospective and retrospective analyses to determine prognostic indices for survival.
(3) Many ministers believe his position is irretrievable, while others believe Brown may eventually recover if voters look to the future.
(4) In his strongly worded judgement, Wildblood listed the council’s multiple mistakes point by point and warned that the child’s chance of a permanent family had been irretrievably shattered.
(5) Complications in the furture are likely to be progressive sclerosis from irretrievable fragments and knots of the artificial materials and conceivably malignant degeneration of tissues of the scalp.
(6) Inhibitor activity was registered even if sera were not present in cell culture continuously but only 6 hours of preincubation; then their action was irretrievable.
(7) His lack of communication and isolating people and strictly controlling all information has made your party less effective.” Labor MP Nicole Manison said the government was “irretrievable.” “It has been very clear.. that there are some deep problems within the government and they are not going to be fixed, it’s gone too far,” she said.
(8) He said: "The [MoJ] proposals will undermine the position of the independent bar, irretrievably and forever.
(9) He was also dissatisfied with Moody’s role and it quickly became apparent during his talks with Parish that the damage was irretrievable.
(10) Clarity on this point would enable Britain to start making a crucial point to our counterparties: the four freedoms of the single market are neither immutable nor irretrievably interdependent.
(11) In the divorce filing released on Wednesday, Murdoch's lawyers said that the "relationship between husband and wife had broken down irretrievably".
(12) Bruce is understood to have left with a heavy heart but felt his position had become untenable and that his much-soured relationship with Ehab Allam, the vice-chairman, was irretrievable.
(13) With the game seemingly irretrievable, Rodgers sent on Daniel Sturridge at half-time.
(14) Cytoplasm and organelles become entrapped in the upward movement of granules towards the cell apex, become irretrievably isolated, and are sloughed into the crypt lumen.
(15) He said formal consultation with Indigenous leaders, which has not yet begun, ought to have begun months ago, and the relationship between the government and leadership structures in the Kimberley had now “broken down irretrievably”.
(16) Clegg will try to persuade the electorate the party has changed irretrievably, saying: "The past is gone and it isn't coming back.
(17) Surgical therapy has three roles in disseminated atheroembolism: prevention of further atheroembolism with its attendant peripheral or visceral organ damage; amputation or resection of irretrievably damaged tissue; and provision of chronic hemodialysis access.
(18) The UK would be irretrievably damaged and could face separation if the electorate votes to leave the European Union in the referendum planned by David Cameron after next year’s general election, a leading pro-Europe Tory has said.
(19) Thus, it appears that most CTL precursor cells may be lost or irretrievably inactivated in the spleens of late TBH mice.
(20) Carelessness will result in evidence being irretrievably lost.
Irreversible
Definition:
(a.) Incapable of being reversed or turned about or back; incapable of being made to run backward; as, an irreversible engine.
(a.) Incapable of being reversed, recalled, repealed, or annulled; as, an irreversible sentence or decree.
Example Sentences:
(1) The specific limited trypsinolysis of bacteriophage T7 RNA polymerase (T7RP) was performed in the presence of various components of the polymerase reaction and some GTP-analogs--irreversible inhibitors of the enzyme.
(2) At 24 or 48 hours after ischemia, 63Ni, 99TcO4, and 22Na were preferentially concentrated in the damaged striatum and hippocampus, whereas 65Zn, 59Fe, 32PO4, and 147Pm did not accumulate in irreversibly injured tissue.
(3) The illumination of the F1-ATPase complexes with NAB-ADP or NAB-GDP leads to the covalent binding of one nucleotide analogue molecule to the enzyme and to the irreversible inactivation of F1-ATPase.
(4) The inhibition was irreversible, as well as time and concentration dependent, which indicates a suicide-inhibition type of metabolism.
(5) It is unclear if the changes in high-energy phosphates during endotoxin shock cause irreversibility.
(6) These studies indicate that, in three models of acute liver injury, the net influx of calcium across the plasma membrane is increased early in the evolution of the injury before irreversible damage occurs.
(7) The kinetics of association of the radioligand suggested the presence of a rapidly associating, reversible binding site, and a slowly associating, apparently irreversible one.
(8) The high capacity of irreversible synthetic-state, smooth muscle cells to bind and accumulate beta-VLDL in contrast to the relative immunity of contractile cells may be relevant to the genesis of atherosclerosis in the rabbit and possibly also in humans.
(9) In the MVD, all esters appeared to irreversibly block the agonist effect of morphine, but none of the compounds irreversibly antagonized [D-Ala2,D-Leu5]enkephalin to a significant degree.
(10) The coronary vasoconstrictor response produced by ibopamine was inhibited completely by the irreversible alpha-adrenoceptor antagonist, phenoxybenzamine, whereas the response produced by epinine was transformed into relaxation which was inhibited by the beta-adrenoceptor antagonist, propranolol.
(11) It is concluded that vasectomy should no longer be considered an irreversible procedure.
(12) No correlation occurred between specific immunopatterns and irreversible brochopulmonary lesions.
(13) In patients under anti-epileptic therapy it is readily possible for the clinical picture to be concealed, and this may then result in irreversible damage due to the disturbance of metabolism remaining uninfluenced.
(14) When tissue metabolism was irreversibly inhibited by exposure to formaldehyde, hydrogen ion concentration and pCO2 were significantly decreased in the mucosal side of the chamber compared with the viable gall bladder.
(15) More than 20 years ago Olney and his colleagues described the 'Excitotoxic Hypothesis' which postulates that, in addition to its normal function in the healthy brain, glutamate can kill neurons by prolonged, receptor-mediated depolarization resulting in irreversible disturbances in ion homeostasis.
(16) Hypercalcaemia is a common disorder, which frequently requires specific treatment either to control symptoms, or to prevent the development of irreversible organ damage or death.
(17) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(18) The rate of the irreversible damage to the reaction center II, caused by exposure of spinach thylakoids to high light was slowed down by anaerobic conditions and by lowering the temperature.
(19) Rheumatoid arthritis, a disease of unknown aetiology, has a multifactorial pathogenesis which may result in irreversible connective tissue destruction and loss of joint function.
(20) Although neither patient exhibited a toxic effect, these levels may be associated with an increased risk of thioridazine-induced irreversible pigmentary retinopathy, cardiac arrhythmias, and tardive dyskinesia.