(a.) Incapable of being reversed or turned about or back; incapable of being made to run backward; as, an irreversible engine.
(a.) Incapable of being reversed, recalled, repealed, or annulled; as, an irreversible sentence or decree.
Example Sentences:
(1) The specific limited trypsinolysis of bacteriophage T7 RNA polymerase (T7RP) was performed in the presence of various components of the polymerase reaction and some GTP-analogs--irreversible inhibitors of the enzyme.
(2) At 24 or 48 hours after ischemia, 63Ni, 99TcO4, and 22Na were preferentially concentrated in the damaged striatum and hippocampus, whereas 65Zn, 59Fe, 32PO4, and 147Pm did not accumulate in irreversibly injured tissue.
(3) The illumination of the F1-ATPase complexes with NAB-ADP or NAB-GDP leads to the covalent binding of one nucleotide analogue molecule to the enzyme and to the irreversible inactivation of F1-ATPase.
(4) The inhibition was irreversible, as well as time and concentration dependent, which indicates a suicide-inhibition type of metabolism.
(5) It is unclear if the changes in high-energy phosphates during endotoxin shock cause irreversibility.
(6) These studies indicate that, in three models of acute liver injury, the net influx of calcium across the plasma membrane is increased early in the evolution of the injury before irreversible damage occurs.
(7) The kinetics of association of the radioligand suggested the presence of a rapidly associating, reversible binding site, and a slowly associating, apparently irreversible one.
(8) The high capacity of irreversible synthetic-state, smooth muscle cells to bind and accumulate beta-VLDL in contrast to the relative immunity of contractile cells may be relevant to the genesis of atherosclerosis in the rabbit and possibly also in humans.
(9) In the MVD, all esters appeared to irreversibly block the agonist effect of morphine, but none of the compounds irreversibly antagonized [D-Ala2,D-Leu5]enkephalin to a significant degree.
(10) The coronary vasoconstrictor response produced by ibopamine was inhibited completely by the irreversible alpha-adrenoceptor antagonist, phenoxybenzamine, whereas the response produced by epinine was transformed into relaxation which was inhibited by the beta-adrenoceptor antagonist, propranolol.
(11) It is concluded that vasectomy should no longer be considered an irreversible procedure.
(12) No correlation occurred between specific immunopatterns and irreversible brochopulmonary lesions.
(13) In patients under anti-epileptic therapy it is readily possible for the clinical picture to be concealed, and this may then result in irreversible damage due to the disturbance of metabolism remaining uninfluenced.
(14) When tissue metabolism was irreversibly inhibited by exposure to formaldehyde, hydrogen ion concentration and pCO2 were significantly decreased in the mucosal side of the chamber compared with the viable gall bladder.
(15) More than 20 years ago Olney and his colleagues described the 'Excitotoxic Hypothesis' which postulates that, in addition to its normal function in the healthy brain, glutamate can kill neurons by prolonged, receptor-mediated depolarization resulting in irreversible disturbances in ion homeostasis.
(16) Hypercalcaemia is a common disorder, which frequently requires specific treatment either to control symptoms, or to prevent the development of irreversible organ damage or death.
(17) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(18) The rate of the irreversible damage to the reaction center II, caused by exposure of spinach thylakoids to high light was slowed down by anaerobic conditions and by lowering the temperature.
(19) Rheumatoid arthritis, a disease of unknown aetiology, has a multifactorial pathogenesis which may result in irreversible connective tissue destruction and loss of joint function.
(20) Although neither patient exhibited a toxic effect, these levels may be associated with an increased risk of thioridazine-induced irreversible pigmentary retinopathy, cardiac arrhythmias, and tardive dyskinesia.
Irrevocable
Definition:
(a.) Incapable of being recalled or revoked; unchangeable; irreversible; unalterable; as, an irrevocable promise or decree; irrevocable fate.
Example Sentences:
(1) Continuing corporate concerns over the costs of health care, and recent changes in federal policies regarding Medicare and the taxation of employee benefit funds, threaten to alter the system of postretirement health benefits substantially and perhaps irrevocably for many.
(2) It took the first intifada (the largely unarmed, six-year uprising that preceded the current, far more violent one) to transform Yassin wholly and irrevocably, and to pitchfork him into the forefront of the Palestinian struggle as a serious rival to Arafat himself.
(3) The council had been politically unstable and divided, and although parents were voting with their feet – less than half were choosing to send their children to the borough's secondary schools – there was a widespread feeling that nothing could be done, that the borough's failings were irrevocable.
(4) Tsipras also emphasised that Greece is a “sovereign country with an irrevocable right to conduct a multi-faceted foreign policy”.
(5) Monocytic differentiation was reversible upon removal of CSF-1, implying that CSF-1 was required for maintenance of the monocyte phenotype but was not sufficient to induce an irrevocable commitment to differentiation.
(6) Fertility in women 40 years of age or older is decreased, and in those with ovarian failure it is thought to be irrevocably lost.
(7) Still, there's an upside to 007's monogamy, and it may just explain how this much-maligned film has wheedled its way so irrevocably into my affections: uniquely in the world of Bond, it allows a vein of romantic adventure to develop that's real, not illusory.
(8) The reason for King's change of view is simple: he believes the world changed irrevocably on 15 September last year when the collapse of Lehman Brothers set off a month of financial turmoil that plunged the global economy into a deep slump.
(9) In the first experiment, 14-day prenatal lung explants (14 + 0 days) containing macrophage precursors but not matured cells were exposed to individual CSFs for 7 days in an attempt to determine whether precursors are committed irrevocably to the macrophage line or can be altered by exposure to factors promoting significant granulocyte development.
(10) The team’s failure led to the immediate and “irrevocable” resignations of both the manager and the president of the Italian federation, Giancarlo Abete.
(11) Above all, he must face the increasing suggestion that his party is irrevocably on course to do significantly worse with him as its leader in the 2015 general election than it would do under someone new, specifically the business secretary Vince Cable .
(12) Lord Mandelson, the former Labour business secretary, has also said he is no longer a supporter and that Labour should "think twice before binding themselves irrevocably" to the project Patrick McLoughlin, the transport secretary, rejected Darling's claim that going ahead with HS2 could have "catastrophic" consequences for spending on other transport infrastructure.
(13) In a sworn affidavit accompanying the motion, Dershowitz states that Roberts’s lawyers “levelled totally false and outrageous charges against me that have been damaged around the world and threaten to damage my reputation irrevocably”.
(14) Without the presence and participation of those Jews, Europe irrevocably lost a crucial and invaluable element of its identity.
(15) "We, the people of the Azawad [desert region] proclaim the irrevocable independence of the state of the Azawad starting from this day, Friday 6 April 2012," the statement read.
(16) The irrevocable breakdown of leucine was estimated from the 3H-labelling of body water.
(17) Particularly grave in its consequences is the gastric stump carcinoma with its fateful and irrevocable course for patients with B II gastrectomy if regular gastroscopic and laboratory follow-up inspection do not take place (regardless of questionable operation indication).
(18) Do your own due diligence before making irrevocable choices.
(19) Michael Jacobs, senior adviser for the New Climate Economy project, says the long-term goals in the agreement send investors the clearest sign “that the world was on an irreversible and irrevocable downward trend in emissions”.
(20) But there are deep nerves in Whitehall that George Osborne is reaching the stage where voters will make an irrevocable judgment that he has failed to deliver his two key economic pledges made during the 2010 election.