(a.) Incapable of being reversed or turned about or back; incapable of being made to run backward; as, an irreversible engine.
(a.) Incapable of being reversed, recalled, repealed, or annulled; as, an irreversible sentence or decree.
Example Sentences:
(1) The specific limited trypsinolysis of bacteriophage T7 RNA polymerase (T7RP) was performed in the presence of various components of the polymerase reaction and some GTP-analogs--irreversible inhibitors of the enzyme.
(2) At 24 or 48 hours after ischemia, 63Ni, 99TcO4, and 22Na were preferentially concentrated in the damaged striatum and hippocampus, whereas 65Zn, 59Fe, 32PO4, and 147Pm did not accumulate in irreversibly injured tissue.
(3) The illumination of the F1-ATPase complexes with NAB-ADP or NAB-GDP leads to the covalent binding of one nucleotide analogue molecule to the enzyme and to the irreversible inactivation of F1-ATPase.
(4) The inhibition was irreversible, as well as time and concentration dependent, which indicates a suicide-inhibition type of metabolism.
(5) It is unclear if the changes in high-energy phosphates during endotoxin shock cause irreversibility.
(6) These studies indicate that, in three models of acute liver injury, the net influx of calcium across the plasma membrane is increased early in the evolution of the injury before irreversible damage occurs.
(7) The kinetics of association of the radioligand suggested the presence of a rapidly associating, reversible binding site, and a slowly associating, apparently irreversible one.
(8) The high capacity of irreversible synthetic-state, smooth muscle cells to bind and accumulate beta-VLDL in contrast to the relative immunity of contractile cells may be relevant to the genesis of atherosclerosis in the rabbit and possibly also in humans.
(9) In the MVD, all esters appeared to irreversibly block the agonist effect of morphine, but none of the compounds irreversibly antagonized [D-Ala2,D-Leu5]enkephalin to a significant degree.
(10) The coronary vasoconstrictor response produced by ibopamine was inhibited completely by the irreversible alpha-adrenoceptor antagonist, phenoxybenzamine, whereas the response produced by epinine was transformed into relaxation which was inhibited by the beta-adrenoceptor antagonist, propranolol.
(11) It is concluded that vasectomy should no longer be considered an irreversible procedure.
(12) No correlation occurred between specific immunopatterns and irreversible brochopulmonary lesions.
(13) In patients under anti-epileptic therapy it is readily possible for the clinical picture to be concealed, and this may then result in irreversible damage due to the disturbance of metabolism remaining uninfluenced.
(14) When tissue metabolism was irreversibly inhibited by exposure to formaldehyde, hydrogen ion concentration and pCO2 were significantly decreased in the mucosal side of the chamber compared with the viable gall bladder.
(15) More than 20 years ago Olney and his colleagues described the 'Excitotoxic Hypothesis' which postulates that, in addition to its normal function in the healthy brain, glutamate can kill neurons by prolonged, receptor-mediated depolarization resulting in irreversible disturbances in ion homeostasis.
(16) Hypercalcaemia is a common disorder, which frequently requires specific treatment either to control symptoms, or to prevent the development of irreversible organ damage or death.
(17) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(18) The rate of the irreversible damage to the reaction center II, caused by exposure of spinach thylakoids to high light was slowed down by anaerobic conditions and by lowering the temperature.
(19) Rheumatoid arthritis, a disease of unknown aetiology, has a multifactorial pathogenesis which may result in irreversible connective tissue destruction and loss of joint function.
(20) Although neither patient exhibited a toxic effect, these levels may be associated with an increased risk of thioridazine-induced irreversible pigmentary retinopathy, cardiac arrhythmias, and tardive dyskinesia.
Reversible
Definition:
(a.) Capable of being reversed; as, a chair or seat having a reversible back; a reversible judgment or sentence.
(a.) Hence, having a pattern or finished surface on both sides, so that either may be used; -- said of fabrics.
Example Sentences:
(1) This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline.
(2) Application of 40 microM NiCl2 reversibly blocked It while leaving Is intact, whereas 20 microM CdCl2 reversibly blocked Is, but not It.
(3) The outward currents are sensitive to TEA and their reversal potentials differ.
(4) With NaCl as the major constituent of the bathing solution (potassium-free pipette and external solutions) the reversal potential (Er) of the noradrenaline-evoked current was about 0 mV.
(5) The HBV infection was tested by the reversed passive hemagglutination method for the HBsAg and by the passive hemagglutination method for the anti-HBs at the time of recruitment in 1984.
(6) If the method was taken into routine use in a diagnostic laboratory, the persistence of reverse passive haemagglutination reactions would enable grouping results to be checked for quality control purposes.
(7) Tests showed the cells survive and function normally in animals and reverse movement problems caused by Parkinson's in monkeys.
(8) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(9) Head-injured patients had a low thyroxine (T4), low triiodothyronine (T3), and high reverse T3.
(10) Dilutional studies comparing the mechanism of inhibition of monoamine oxidase produced by Gerovital H3 and by ipronizid demonstrated that Gerovital H3 was a reversible inhibitor of monoamine oxidase.
(11) Nucleotide, which is essential for catalysis, greatly enhances the binding of IpOHA by the reductoisomerase, with NADPH (normally present during the enzyme's rearrangement step, i.e., conversion of a beta-keto acid into an alpha-keto acid, in either the forward or reverse physiological reactions) being more effective than NADP.
(12) An axillo-axillary bypass procedure was performed in a high-risk patient with innominate arterial stenosis who had repeated episodes of transient cerebral ischemia due to decreased blood flow through the right carotid artery and reversal of blood flow through the right vertebral artery.
(13) What reforms there were could also be reversed, she warned.
(14) No reversions to wild-type levels were observed in 555 heterozygous offspring of crosses between homozygous Campines and normals.
(15) We have compared two new methods (a solvent extraction technique and a method involving a disposable, pre-packed reverse phase chromatography cartridge) with the standard method for determining the radiochemical purity of 99Tcm-HMPAO.
(16) Sickle and normal discocytes both showed membrane elasticity with reversion to original cell shape following release of the cell from its aspirated position at the pipette tip.
(17) These antagonists reverse NMDA-mediated long term influence in these brain areas.
(18) For dental procedures requiring tracheal intubation, one could perhaps use non-depolarizing muscle relaxants, like pancuronium, with reversal at the end of the procedure.
(19) We have recently described a nonnucleoside compound that specifically inhibits the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS.
(20) We have investigated some of the factors which affect the retention times of these substances in reversed-phase HPLC on columns of 5-micron octadecylsilyl silica.